Results 31 to 40 of about 78,579 (231)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Ecology and EvolutionGenetic drift, gene flow, and natural selection commonly influence population genetic diversity. In populations of self‐compatible hermaphrodites, the mating system (e.g., self‐fertilization) further reduces individual heterozygosity.
Cansu Çetin +5 more
doaj +1 more source
Phenotypic stasis with genetic divergence
Peer Community Journal, 2023 Whether or not genetic divergence in the short-term of tens to hundreds of generations is compatible with phenotypic stasis remains a relatively unexplored problem.
Mallard, François +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman +17 more
wiley +1 more source
The Genetic Drift of Indonesian Avian Influenza A H5N1 Viruses During 2003-2008
Microbiology Indonesia, 2011 The avian influenza A H5N1 outbreaks started in 2003 and Indonesia introduced a vaccination campaign in 2004 to control the disease. In 2007, anecdotal reports about reduced vaccine effectiveness were received from commercial farmers.
NI LUH PUTU INDI DHARMAYANTI +5 more
doaj +1 more source
Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy +5 more
wiley +1 more source
Global Amphibian Declines, Loss of Genetic Diversity and Fitness: A Review
Diversity, 2010 It is well established that a decrease in genetic variation can lead to reduced fitness and lack of adaptability to a changing environment. Amphibians are declining on a global scale, and we present a four-point argument as to why this taxonomic group ...
John O’Brien, Morten E. Allentoft
doaj +1 more source
Implementing Health‐Related Quality of Life Assessment in Pediatric Oncology: A Feasibility Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background There is growing interest in embedding health‐related quality of life (HRQoL) assessment and patient‐reported outcome measures (PROMs) within clinical cancer care. This study evaluated the feasibility, acceptability, and usability of implementing an electronic PROM (ePROM) platform to measure HRQoL in children with cancer ...
Mikaela Doig +13 more
wiley +1 more source
Does gene flow aggravate or alleviate maladaptation to environmental stress in small populations?
Evolutionary Applications, 2019 Environmental change can expose populations to unfamiliar stressors, and maladaptive responses to those stressors may result in population declines or extirpation.
Sarah W. Fitzpatrick, Brendan N. Reid
doaj +1 more source
Polygenic Adaptation in a Population of Finite Size
Entropy, 2020 Polygenic adaptation in response to selection on quantitative traits has become an important topic in evolutionary biology. Here we review the recent literature on models of polygenic adaptation.
Wolfgang Stephan, Sona John
doaj +1 more source