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Genetic engineering frontiers in cell manipulation-based tissue engineering: A comprehensive review [PDF]

BioImpacts
Introduction: A new era of regenerative medicine has been ushered in by the combination of tissue engineering and genetic engineering, offering unprecedented opportunities to address the growing demand for functional tissue replacements.
Amirhossein Mohammadi, Mohammad Ali Heydari, Zahra Jamalpoor   +2 more
doaj   +2 more sources

Genetic Engineering of Humanized Telomere Mice [PDF]

Bio-Protocol
Telomere shortening is a hallmark of human aging, and telomerase regulation plays a critical role in cellular proliferation and replicative senescence. In human cells, telomere length imposes a limit on proliferative potential, a phenomenon known as the ...
Fan Zhang, De Cheng, Kenneth Porter, Shuwen Wang, Jiyue Zhu   +4 more
doaj   +2 more sources

Emerging Trends in Genetic Engineering of Microalgae for Commercial Applications

Marine Drugs, 2022
Recently, microalgal biotechnology has received increasing interests in producing valuable, sustainable and environmentally friendly bioproducts. The development of economically viable production processes entails resolving certain limitations of ...
Samir B. Grama, Zhiyuan Liu, Jian Li
doaj   +3 more sources

Genetic engineering and the eye. [PDF]

Eye (Lond)
Abstract The transformative potential of genetic engineering in ophthalmology is remarkable, promising new treatments for a wide range of blinding eye diseases. The eye is an attractive target organ for genetic engineering approaches, in part due to its relatively immune-privileged status, its accessibility, and the ease of monitoring of ...
Murphy R, Martin KR.
europepmc   +3 more sources

Nanodelivery of nucleic acids for plant genetic engineering [PDF]

Discover Nano
Genetic engineering in plants serves as a crucial method for enhancing crop quality, yield, and climate resilience through the manipulation of genetic circuits.
Shufeng Liu, Yixian Zheng, Linsi Pan, Wencai Wang, Yongquan Li, Zhaojun Liu, Xianzhi Zhang   +6 more
doaj   +2 more sources

RNA Interference-Based Genetic Engineering Maize Resistant to Apolygus lucorum Does Not Manifest Unpredictable Unintended Effects Relative to Conventional Breeding: Short Interfering RNA, Transcriptome, and Metabolome Analysis

Frontiers in Plant Science, 2022
The use of omics techniques to analyze the differences between genetic engineering organisms and their parents can identify unintended effects and explore whether such unintended effects will have negative consequences.
Chunmeng Huang, Chunmeng Huang, Zhi Wang, Pengyu Zhu, Chenguang Wang, Chaonan Wang, Chaonan Wang, Wenjie Xu, Zhihong Li, Wei Fu, Shuifang Zhu   +10 more
doaj   +1 more source

Genetic engineering in organoids [PDF]

Journal of Molecular Medicine, 2021
AbstractThree-dimensional organoids have been widely used for developmental and disease modeling. Organoids are derived from both adult and pluripotent stem cells. Various types are available for mimicking almost all major organs and tissues in the mouse and human.
Isaree Teriyapirom, Andreia S. Batista-Rocha, Bon-Kyoung Koo   +2 more
openaire   +2 more sources

Genetic Engineering Technologies for Improving Crop Yield and Quality

Agronomy, 2022
Genetic engineering refers to the specific molecular biological modification of DNA sequences. With the rapid development of genetic engineering methods, especially the breakthroughs in guiding endonuclease technology, gene remodeling of crops has become
Runle Ye, Xi Yang, Yuchun Rao
doaj   +1 more source

Evaluation of Melongosides as Potential Inhibitors of NS2B-NS3 Activator-Protease of Dengue Virus (Serotype 2) by Using Molecular Docking and Dynamics Simulation Approach

Journal of Tropical Medicine, 2022
Dengue is a Flavivirus infection transmitted through mosquitoes of the Aedes genus, which is known to occur in over 100 countries of the world. Dengue has no available drugs for treatment; CYD-TDV is the only vaccine thus far approved for use by a few ...
Partha Biswas, Ommay Hany Rumi, Dhrubo Ahmed Khan, Md Nasir Ahmed, Nusratun Nahar, Rownak Jahan, Md Nazmul Hasan Zilani, Tridib K Paul, Anamul Hasan, Tohmina Afroze Bondhon, Khoshnur Jannat, Md Nazmul Hasan, Mohammed Rahmatullah   +12 more
doaj   +1 more source

Combinatorial approaches for inverse metabolic engineering applications

Computational and Structural Biotechnology Journal, 2012
Traditional metabolic engineering analyzes biosynthetic and physiological pathways, identifies bottlenecks, and makes targeted genetic modifications with the ultimate goal of increasing the production of high-value products in living cells.
Georgios Skretas, Fragiskos N Kolisis
doaj   +3 more sources