Results 181 to 190 of about 731,889 (291)

From Delta to Omicron-Genetic Epidemiology of SARS-CoV-2 (hCoV-19) in Southern Poland. [PDF]

Pathogens
Miklasińska-Majdanik M, Morawiec E, Bratosiewicz-Wąsik J, Serwin K, Pudełko A, Czerwiński M, Bednarska-Czerwińska A, Parczewski M, Wąsik TJ.   +8 more
europepmc   +1 more source

Genetic epidemiology of BRCA1- and BRCA2-associated cancer across Latin America. [PDF]

NPJ Breast Cancer, 2021
Herzog JS, Chavarri-Guerra Y, Castillo D, Abugattas J, Villarreal-Garza C, Sand S, Clague-Dehart J, Alvarez-Gómez RM, Wegman-Ostrosky T, Mohar A, Mora P, Del Toro-Valero A, Daneri-Navarro A, Rodriguez Y, Cruz-Correa M, Ashton-Prolla P, Alemar B, Mejia R, Gallardo L, Shaw R, Yang K, Cervantes A, Tsang K, Nehoray B, Barrera Saldana H, Neuhausen S, Weitzel JN.   +26 more
europepmc   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Editorial: Methods in applied genetic epidemiology 2022. [PDF]

Front Genet
Guo Q, Foley CN, Kuncheva Z.
europepmc   +1 more source

Genetic epidemiology of hemoglobinopathies among Iraqi Kurds. [PDF]

J Community Genet, 2021
Al-Allawi N, Al Allawi S, Jalal SD.
europepmc   +1 more source

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

Genetic Epidemiology and Antimicrobial Susceptibilities of Carbapenem-Resistant <i>Pseudomonas aeruginosa</i> Isolates from a Multicenter Study in Korea. [PDF]

Infect Chemother
Kim T, Hong YK, Park S, Jung J, Cho OH, Shin HB, Choi TY, Choi YJ, Kim MN, Chong YP.   +9 more
europepmc   +1 more source

An exploration of the genetic epidemiology of non-suicidal self-harm and suicide attempt. [PDF]

BMC Psychiatry, 2021
Russell AE, Hemani G, Jones HJ, Ford T, Gunnell D, Heron J, Joinson C, Moran P, Relton C, Suderman M, Watkins S, Mars B.   +11 more
europepmc   +1 more source

scResponse: A Rank‐Based Method for Identifying Cell States That Contribute to Immunotherapy Response by Single‐Cell Data

Advanced Science, EarlyView.
Although the tumor microenvironment is known to shape immunotherapy response, its key determinants remain elusive, underscoring the critical need for single‐cell resolution analytical frameworks. We present scResponse, an efficient algorithm to quantify single‐cell responses to immunotherapy. By capturing diverse cellular subtypes and states associated
Qi Dong, Haijun Huang, Yuxiu Wang, Bo Jiang, Yuzheng Chen, Huanhuan Xu, Jing Ren, Shengnan Guo, Tianhao Li, Mingjie Zhang, Tianyu Zhai, Wenbo Yang, Kaidong Liu, Cheng Lyu, Jingxuan Kang, Mingshuo Zhang, Yupeng Lu, Binghui Si, Shujun Cao, Dandan Xu, Zong Chen, Dapeng Hao   +21 more
wiley   +1 more source

Epidemiology/Genetics

Diabetes, 2011
openaire   +4 more sources