Results 21 to 30 of about 735,632 (337)

Distinct genealogies for plasmids and chromosome [PDF]

, 2014
An earlier perspective on the diversity of conjugative elements in microbes [1] attempted to provide a broad audience with an introductory overview of the arcane biology of mobile genetic elements and their terminologies. It might well have been entitled
Achtman, Mark, Zhou, Zhemin
core   +2 more sources

A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study

Scientific Reports, 2023
The availability of polygenic scores for type 2 diabetes (T2D) raises the question, whether assessing family history might become redundant. However, family history not only involves shared genetics, but also shared environment.
Elena Duschek, Lukas Forer, Sebastian Schönherr, Christian Gieger, Annette Peters, Florian Kronenberg, Harald Grallert, Claudia Lamina   +7 more
doaj   +1 more source

Molecular epidemiology of African sleeping sickness [PDF]

, 2009
Human sleeping sickness in Africa, caused by Trypanosoma brucei spp. raises a number of questions. Despite the widespread distribution of the tsetse vectors and animal trypanosomiasis, human disease is only found in discrete foci which periodically give ...
A. TAIT, G. HIDE, Gibson, Hide, Mehlitz, Morrison   +5 more
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Gut microbiota associations with common diseases and prescription medications in a population-based cohort

Nature Communications, 2018
The human gut microbiome has been associated with many health factors, but variability between studies limits exploration of these effects. Here, Jackson et al.
Matthew A. Jackson, Serena Verdi, Maria-Emanuela Maxan, Cheol Min Shin, Jonas Zierer, Ruth C. E. Bowyer, Tiphaine Martin, Frances M. K. Williams, Cristina Menni, Jordana T. Bell, Tim D. Spector, Claire J. Steves   +11 more
doaj   +1 more source

Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci

Nature Communications, 2018
Genomic polymorphisms affect the epigenome, which in turn influences how epigenome- and genome-wide analysis are interpreted. Here, the authors characterise allelic differences in DNA methylation driven by obligatory or facilitative genetic effects ...
Christopher G. Bell, Fei Gao, Wei Yuan, Leonie Roos, Richard J. Acton, Yudong Xia, Jordana Bell, Kirsten Ward, Massimo Mangino, Pirro G. Hysi, Jun Wang, Timothy D. Spector   +11 more
doaj   +1 more source

Interplay between the human gut microbiome and host metabolism

Nature Communications, 2019
Here, the authors study the interplay between the microbiome and faecal and blood metabolome, and how the microbiome interacts in the dialogue between these metabolic compartments, identifying a key role for microbial functions and underscoring their ...
Alessia Visconti, Caroline I. Le Roy, Fabio Rosa, Niccolò Rossi, Tiphaine C. Martin, Robert P. Mohney, Weizhong Li, Emanuele de Rinaldis, Jordana T. Bell, J. Craig Venter, Karen E. Nelson, Tim D. Spector, Mario Falchi   +12 more
doaj   +1 more source

On the biological and genetic diversity in Neospora caninum [PDF]

, 2010
Published: 22 March 2010Neospora caninum is a parasite regarded a major cause of foetal loss in cattle. A key requirement to an understanding of the epidemiology and pathogenicity of N.
Barber, Barr, Bjerkås, Bjerkås, Buxton, Buxton, Davison, Dubey, Dubey, Dubey, Dubey, Dubey, Dubey, Ellis, González-Warleta, Hay, Holmdahl, Howe, John T. Ellis, Kaufmann, King, Lehmann, Lindsay, Locatelli-Dittrich, Magnino, McAllister, McGuire, Michael P. Reichel, Paré, Pastusiak, Sarwat E. Al-Qassab, Schock, Shibahara, Shin, Siverajah, Speer, Trees, Yamane   +37 more
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KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies

BMC Bioinformatics, 2023
Background Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with kidney function. By combining these findings with post-GWAS information (e.g., statistical fine-mapping to identify independent association signals
Kira J. Stanzick, Klaus J. Stark, Mathias Gorski, Johannes Schödel, René Krüger, Florian Kronenberg, Richard Warth, Iris M. Heid, Thomas W. Winkler   +8 more
doaj   +1 more source

Genetic determinants of cortical structure (thickness, surface area and volumes) among disease free adults in the CHARGE Consortium [PDF]

, 2019
Cortical thickness, surface area and volumes (MRI cortical measures) vary with age and cognitive function, and in neurological and psychiatric diseases.
Adams, H., Ahmad, S., Ames, D., Amin, N., Amouye, P., Andreassen, O., Armstrong, N., Bastin, M., Becker, J., Beiser, A., Bernard, M., Beyer, F., Bis, J., Bralten, J., Brodaty, H., Bülow, R., Carmichael, O., Colodro-Conde, L., Crivello, F., Dale, A., Deary, I., Debette, S., DeCarli, C., Fornage, M., Franz, C., Gillespie, N., Grabe, H., Grasby, K., Harris, M., Hibar, D., Himali, J., Hofer, E., Hofman, A., Ikram, M., Jahanshad, N., Jian, X., Jiang, J., Karama, S., Knol, M., Kremen, W., Kwok, J., Lewis, L., Li, S., Lin, H., Lind, P., Loeffler, M., Logue, M., Longstreth Jr., W., Lopez, O., Luciano, M., Lyons, M., Maillard, P., Maingault, S., Mather, K., Mazoyer, B., Medland, S., Mishra, A., Mosley, T., Neale, M., Niessen, W., Painter, J., Panizzon, M., Paus, T., Pausova, Z., Pike, G., Pirpamer, L., Pizzagalli, F., Psaty, B., Roshchupkin, G., Rotter, J., Saba, Y., Sachdev, P., Satizabal, C., Schmid, R., Schmidt, H., Schofield, P., Scholz, M., Seiler, S., Seshadr, S., Stein, J., Teumer, A., Thalamuthu, A., Thompson, P., Trollor, J., Tzourio, C., Uitterlinden, A., van der Lee, S., van Duijn, C., Vernooij, M., Villringer, A., Völker, U., Wardlaw, J., Wen, W., Witte, A., Wittfeld, K., Wright, M., Xia, R., Yang, Q., Zare, H.   +98 more
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Validation of differentially methylated microRNAs identified from an epigenome-wide association study; Sanger and next generation sequencing approaches

BMC Research Notes, 2018
Objectives Altered DNA methylation and microRNA profiles are associated with diabetic kidney disease. This study compared different sequencing approaches to define the genetic and epigenetic architecture of sequences surrounding microRNAs associated with
Laura J. Smyth, Alexander P. Maxwell, Katherine A. Benson, Jill Kilner, Gareth J. McKay, Amy Jayne McKnight   +5 more
doaj   +1 more source