Results 161 to 170 of about 1,295,297 (304)

Editorial: Accelerating genetic gain for key traits using genome-wide association studies and genomic selection: promising breeding tools for sustainable agriculture. [PDF]

Front Genet, 2023
Mishra DC, Budhlakoti N, Juliana P, Kumar S.   +3 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Unlocking the hidden variation from wild repository for accelerating genetic gain in legumes. [PDF]

Front Plant Sci, 2022
Singh G, Gudi S, Amandeep, Upadhyay P, Shekhawat PK, Nayak G, Goyal L, Kumar D, Kumar P, Kamboj A, Thada A, Shekhar S, Koli GK, Dp M, Halladakeri P, Kaur R, Kumar S, Saini P, Singh I, Ayoubi H.   +19 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Enhancing genetic gain through the application of genomic selection in developing irrigated rice for the favorable ecosystem in Bangladesh. [PDF]

Front Genet, 2023
Biswas PS, Ahmed MME, Afrin W, Rahman A, Shalahuddin AKM, Islam R, Akter F, Syed MA, Sarker MRA, Ifterkharuddaula KM, Islam MR.   +10 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Efeito da seleção errônea de machos sobre ganhos genéticos, utilizando-se simulação Effect of errors in the selection of males on the genetic gain using simulation

Revista Brasileira de Zootecnia, 1999
Populações simuladas foram usadas para verificar o efeito de erros na seleção de machos sobre estimativas de ganhos genéticos, ao longo de dez gerações de seleção, usando o BLUP.
Paulo Luiz Souza Carneiro, Ricardo Frederico Euclydes, Martinho de Almeida e Silva, Paulo Sávio Lopes, Robledo de Almeida Torres, Antônio Policarpo Souza Carneiro, Rodolpho de Almeida Torres Filho   +6 more
doaj  

Mate selection: A useful approach to maximize genetic gain and control inbreeding in genomic and conventional oil palm (Elaeis guineensis Jacq.) hybrid breeding. [PDF]

PLoS Comput Biol, 2023
Tchounke B, Sanchez L, Bell JM, Cros D.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Optimal Contribution Selection Improves the Rate of Genetic Gain in Grain Yield and Yield Stability in Spring Canola in Australia and Canada. [PDF]

Plants (Basel), 2023
Cowling WA, Castro-Urrea FA, Stefanova KT, Li L, Banks RG, Saradadevi R, Sass O, Kinghorn BP, Siddique KHM.   +8 more
europepmc   +1 more source