Results 171 to 180 of about 588,080 (302)

Integrated Approach in Genomic Selection to Accelerate Genetic Gain in Sugarcane. [PDF]

Plants (Basel), 2022
Sandhu KS, Shiv A, Kaur G, Meena MR, Raja AK, Vengavasi K, Mall AK, Kumar S, Singh PK, Singh J, Hemaprabha G, Pathak AD, Krishnappa G, Kumar S.   +13 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Impact of kinship matrices on genetic gain and inbreeding with optimum contribution selection in a genomic dairy cattle breeding program. [PDF]

Genet Sel Evol, 2023
Gautason E, Sahana G, Guldbrandtsen B, Berg P.   +3 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Editorial: Accelerating genetic gain for key traits using genome-wide association studies and genomic selection: promising breeding tools for sustainable agriculture. [PDF]

Front Genet, 2023
Mishra DC, Budhlakoti N, Juliana P, Kumar S.   +3 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

CREB3 gain of function variants protect against ALS [PDF]

Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly evolving neurodegenerative disease arising from the loss of glutamatergic corticospinal neurons (CSN) and cholinergic motoneurons (MN).
Veldink, Jan H., Mendoza-Parra, Marco Antonio, Hernán-Godoy, Marina, Stuart-Lopez, Geoffrey, Traynor, Bryan, Dirrig-Grosch, Sylvie, Gorin, Charlotte, Scholz, Sonja W., Fischer, Mathieu, Ludolph, Albert, Megat, Salim, Brunet, Aurore, Keime, Céline, Kessler, Pascal, Dupuis, Luc, Marques, Christine, Sellier, Chantal, Zwamborn, Ramona A.J., Chio, Adriano, Rouaux, Caroline, Ferrucci, Luigi   +20 more
core  

Advanced Generation Seed Orchard of <i>Abies alba</i> Mill. in Romania Combining Genetic Gain and Diversity. [PDF]

Plants (Basel)
Mihai G, Alexandru AM, Teodosiu M, Stoica E, Garbacea P, Ifrim L.   +5 more
europepmc   +1 more source

Unlocking the hidden variation from wild repository for accelerating genetic gain in legumes. [PDF]

Front Plant Sci, 2022
Singh G, Gudi S, Amandeep, Upadhyay P, Shekhawat PK, Nayak G, Goyal L, Kumar D, Kumar P, Kamboj A, Thada A, Shekhar S, Koli GK, Dp M, Halladakeri P, Kaur R, Kumar S, Saini P, Singh I, Ayoubi H.   +19 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source