Results 171 to 180 of about 585,798 (302)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Unlocking the hidden variation from wild repository for accelerating genetic gain in legumes. [PDF]

Front Plant Sci, 2022
Singh G, Gudi S, Amandeep, Upadhyay P, Shekhawat PK, Nayak G, Goyal L, Kumar D, Kumar P, Kamboj A, Thada A, Shekhar S, Koli GK, Dp M, Halladakeri P, Kaur R, Kumar S, Saini P, Singh I, Ayoubi H.   +19 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Culling ewes for maximum genetic gain

, 1970
Farmers are finding it increasingly important to consider both meat and wool production when selecting sheep.
Ralph, I G
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Advanced Generation Seed Orchard of <i>Abies alba</i> Mill. in Romania Combining Genetic Gain and Diversity. [PDF]

Plants (Basel)
Mihai G, Alexandru AM, Teodosiu M, Stoica E, Garbacea P, Ifrim L.   +5 more
europepmc   +1 more source

Mate selection: A useful approach to maximize genetic gain and control inbreeding in genomic and conventional oil palm (Elaeis guineensis Jacq.) hybrid breeding. [PDF]

PLoS Comput Biol, 2023
Tchounke B, Sanchez L, Bell JM, Cros D.
europepmc   +1 more source

CREB3 gain of function variants protect against ALS [PDF]

Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly evolving neurodegenerative disease arising from the loss of glutamatergic corticospinal neurons (CSN) and cholinergic motoneurons (MN).
Veldink, Jan H., Mendoza-Parra, Marco Antonio, Hernán-Godoy, Marina, Stuart-Lopez, Geoffrey, Traynor, Bryan, Dirrig-Grosch, Sylvie, Gorin, Charlotte, Scholz, Sonja W., Fischer, Mathieu, Ludolph, Albert, Megat, Salim, Brunet, Aurore, Keime, Céline, Kessler, Pascal, Dupuis, Luc, Marques, Christine, Sellier, Chantal, Zwamborn, Ramona A.J., Chio, Adriano, Rouaux, Caroline, Ferrucci, Luigi   +20 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Development of a Medium-Density Genotyping Platform to Accelerate Genetic Gain in Fresh Edible Maize. [PDF]

Plants (Basel)
Qu J, Yu D, Gu W, Zhao Y, Li K, Wang H, Sun P, Vicente FS, Zhang X, Zhang A, Zheng H, Guan Y.   +11 more
europepmc   +1 more source