Imputation of non-genotyped F1 dams to improve genetic gain in swine crossbreeding programs. [PDF]
J Anim Sci, 2022 See GM, Fix JS, Schwab CR, Spangler ML.
europepmc +1 more source
Heritability and Genetic Gain in Maize
ANBAR JOURNAL OF AGRICULTURAL SCIENCES, 2010 Benan H. Hadi, Karyma M. Wuhaib
openaire +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Back to the future 2: the implications of germplasm structure on the balance between short- and long-term genetic gain in a changing target population of environments. [PDF]
G3 (Bethesda)Technow F, Podlich D, Cooper M.
europepmc +1 more source
The Effect of Using Organic or Conventional Sires on Genetic Gain in Organic Pigs: A Simulation Study. [PDF]
Animals (Basel), 2022 Zaalberg RM +5 more
europepmc +1 more source
Realized genetic gain in rice: achievements from breeding programs
Genetic improvement is crucial for ensuring food security globally. Indeed, plant breeding has contributed significantly to increasing the productivity of major crops, including rice, over the last century.
Bartholome, Jérôme +3 more
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Understanding rates of genetic gain in sorghum [Sorghum bicolor (L.) Moench] in the United States. [PDF]
Plant GenomeSingh J +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source