Results 201 to 210 of about 585,798 (302)

Conventional and Molecular Breeding Tools for Accelerating Genetic Gain in Faba Bean (Vicia Faba L.). [PDF]

Front Plant Sci, 2021
Adhikari KN, Khazaei H, Ghaouti L, Maalouf F, Vandenberg A, Link W, O'Sullivan DM.   +6 more
europepmc   +1 more source

Optimizing progeny size and number of crosses under genomic selection: insights into additive and epistatic contributions to long-term genetic gain. [PDF]

Theor Appl Genet
da Silva Viana J, DoVale JC, Fritsche-Neto R.   +2 more
europepmc   +1 more source

Genomic selection and genetic gain for nut yield in an Australian macadamia breeding population. [PDF]

BMC Genomics, 2021
O'Connor KM, Hayes BJ, Hardner CM, Alam M, Henry RJ, Topp BL.   +5 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Multi-Decadal Analysis on the Impact of Climate Change, Genetic Gain, Cultivar Type, and Harvest Timing on Main and Ratoon Rice Yield and Quality. [PDF]

Glob Chang Biol
Wilson LT, Samonte SOPB, Yang Y.
europepmc   +1 more source

Genomics and breeding innovations for enhancing genetic gain for climate resilience and nutrition traits. [PDF]

Theor Appl Genet, 2021
Sinha P, Singh VK, Bohra A, Kumar A, Reif JC, Varshney RK.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Realized genetic gain for yield and yield attributes in groundnut breeding at ICRISAT from an ERA trial. [PDF]

Front Plant Sci
Behera PP, Deshmukh D, Vemula AK, Bangaru K, Bagudam R, Mathew A, Purohit A, Vishnumolakala A, Wankhade AP, Kounain S, Guguloth N, Variath MT, Kurva M, Potupureddi G, Muragesan S, Raman A, Pasupuleti J.   +16 more
europepmc   +1 more source

Symmetric response to competition in binary mixtures of cultivars associates with genetic gain in wheat yield. [PDF]

Evol Appl, 2021
Cossani CM, Sadras VO.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source