Results 171 to 180 of about 28,537 (282)

Investigation of adolescent cases diagnosed with idiopathic/genetic generalized epilepsy in terms of self-esteem, aggression, body perception, and alexithymia. [PDF]

Eur J Pediatr
Bozkaya-Yilmaz S, Dagdas SM, Firat E, Basarir G, Ozyurt G, Olgac-Dundar N, Gencpinar P.   +6 more
europepmc   +1 more source

IDENTIFICATION OF DISEASE GENES FOR RARE AUTOSOMAL RECESSIVE EPILEPTIC SYNDROMES BY HOMOZYGOSITY MAPPING

, 2011
Introduction: The genetics of the most common neurological disorders, including epilepsy, with mendelian inheritance has been dissected in the last twenty years. However the genetic etiology of some rare epileptic conditions is still unknown.
Coppola, Antonietta
core  

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Prospective evaluation of clinical characteristics, treatment efficacy, and seizure remission in adult-onset genetic generalized epilepsy. [PDF]

Epilepsia Open
Khalife L, Harb A, Jaafar F, Beydoun A, Wazne J, Toufaili H, Moussa B, Beydoun A.   +7 more
europepmc   +1 more source

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, EarlyView.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model. [PDF]

Cereb Cortex, 2021
Zhang CQ, Catron MA, Ding L, Hanna CM, Gallagher MJ, Macdonald RL, Zhou C.   +6 more
europepmc   +1 more source

Epidemiology of Intensive Nutritional Interventions and Restraints in Hospitalizations for Anorexia Nervosa: Annual National Trends of the United States

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Despite the clinical relevance of enteral and parenteral tube feeding and restraint use in anorexia nervosa (AN), national‐level data on their use have remained limited, particularly for total parenteral nutrition (TPN) and percutaneous endoscopic gastrostomy (PEG).
Hiroyasu Ino, Nancy S. Jecker, Yoshiyuki Takimoto, Eisuke Nakazawa   +3 more
wiley   +1 more source

Proteome-Wide and Immune Cell Phenotype Mendelian Randomization Highlights Immune Involvement in Genetic Generalized Epilepsy. [PDF]

Brain Behav
Gui J, Chu H, Zhang J, Li X, Liu W, Li R, Zhang F, Dong M, Gao K, Luo H, Jiang Y.   +10 more
europepmc   +1 more source

Epilepsy characteristics in patients with muscle‐eye‐brain disease: A systematic review of electroclinical features

Epileptic Disorders, EarlyView.
Abstract Background and Objectives Muscle‐Eye‐Brain disease (MEB) is a dystroglycanopathy that belongs to the congenital muscular dystrophies. Central nervous system manifestations include congenital brain abnormalities, neurodevelopmental delay, and epilepsy, making it a rare but important cause of developmental and epileptic encephalopathy.
Stefania Kalampokini, Evripidis Pityrigkas, Eleni Liouta, Georgia Pepe, Vasiliki Poulidou, Martha Spilioti, Vasilios K. Kimiskidis   +6 more
wiley   +1 more source

Correction To: Felbamate as a therapeutic alternative to drug-resistant genetic generalized epilepsy: a systematic review and meta-analysis. [PDF]

Neurol Sci
Ma Y, Kaminski M, Crutcher R.
europepmc   +1 more source