Results 191 to 200 of about 2,936,182 (239)

Scn1a‐mediated developmental regulation of prefrontal cortex plasticity and cognition

Epilepsia, EarlyView.
Abstract Objective The voltage‐gated sodium channel Nav1.1, encoded by Scn1a, is essential for γ‐aminobutyric acid (GABA)ergic function, and its alteration is associated with neurological disorders such as Dravet syndrome and Alzheimer's disease. We previously demonstrated that local Nav1.1 dysfunction in the medial prefrontal cortex (mPFC) during ...
Maurizio S. Riga, Mercedes Pérez‐Fernández, Yuniesky Andrade‐Talavera, Benito Domínguez‐Velasco, Antonio Rodríguez‐Moreno, Manuel Álvarez‐Dolado   +5 more
wiley   +1 more source

Characterizing sleep disturbances in developmental and epileptic encephalopathies through natural language processing: A retrospective monocentric study

Epilepsia, EarlyView.
Abstract Objective Sleep disorders are frequent but undercharacterized comorbidities in developmental and epileptic encephalopathies (DEEs). We aimed to estimate the frequency, spectrum, and burden of sleep disturbances across genetic DEE subtypes using real‐world data extracted from electronic health records (EHRs) through natural language processing (
Tommaso Lo Barco, Maxime Douillet, Nicole Chemaly, Audrey Duval, Gianluca D'onofrio, Nicolas Garcelon, Xiaoyi Chen, Rima Nabbout   +7 more
wiley   +1 more source

Predicting levetiracetam neuropsychiatric adverse effects using graph‐theoretical electroencephalographic network metrics in drug‐naive focal epilepsy: A multicenter longitudinal study

Epilepsia, EarlyView.
Abstract Objective Levetiracetam (LEV) is an antiseizure medication approved for focal and generalized epilepsy. Despite its efficacy, neuropsychiatric adverse effects (NP‐AEs) may lead to treatment discontinuation. Quantitative electroencephalographic (qEEG) graph‐theoretical analysis has emerged as a valuable tool for identifying neurophysiological ...
Marco Sferruzzi, Lorenzo Ricci, Margherita Anna Grazia Matarrese, Francesca Izzi, Fabio Placidi, Biagio Maria Sancetta, Emanuele Cerulli Irelli, Patrizia Pulitano, Vincenzo Di Lazzaro, Mario Tombini, Giovanni Assenza   +10 more
wiley   +1 more source

Epilepsy surgery through a reproductive lifespan lens

Epilepsia, EarlyView.
Aisha A. Abdulrazaq, Dorothee Kasteleijn‐Nolst Trenite, Torbjörn Tomson   +2 more
wiley   +1 more source

Genetic Causes of Generalized Epilepsies [PDF]

Seminars in Neurology, 2015
Generalized epilepsies, particularly the idiopathic or genetic generalized epilepsies (GGEs), represent some of the most common epilepsies. Clinical genetic data including family studies and twin studies provide compelling evidence for a prominent genetic impact.
Helbig Ingo
exaly   +3 more sources

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Narrative Review of Brivaracetam for Genetic Generalized Epilepsies

Seizure: the Journal of the British Epilepsy Association, 2022
The licensed treatment options for genetic generalized epilepsies are limited although many patients with these conditions require chronic pharmacological management with antiseizure medications and there are no curative surgical treatment options. Brivaracetam is being studied as a new therapeutic option for genetic generalized epilepsies.In order to ...
Sebastian Ortiz De la Rosa
exaly   +3 more sources

Social Impairment and Stigma in Genetic Generalized Epilepsies

Epilepsy and Behavior, 2020
Patients with epilepsy have poor social outcome. Multifactorial factors are usually involved, but among them, stigma features may have an important role. Genetic generalized epilepsies (GGEs) were previously considered "benign" syndromes. The aim of our study was to assess social impairment and stigma in GGE and to evaluate differences between the ...
Denis Gabriel, António Martins da Silva, João Chaves   +2 more
exaly   +3 more sources

Female preponderance in genetic generalized epilepsies

Seizure, 2021
Epilepsy is more prevalent in men but Genetic Generalized Epilepsies (GGE) seem to be more common in women. A predominant maternal inheritance has been previously described in GGE. Our objective was to determine sex and inheritance patterns in a GGE population compared to mesial temporal lobe epilepsy with hippocampal sclerosis (MTLEHS).We performed a ...
Gonçalo, Videira, Denis, Gabriel, Joel, Freitas, Raquel, Samões, Rui, Chorão, João, Lopes, João, Ramalheira, Carolina, Lemos, Bárbara, Leal, António Martins, da Silva, João, Chaves   +10 more
openaire   +2 more sources

Genetic Generalized Epilepsies

Journal of Clinical Neurophysiology, 2012
In the International League Against Epilepsy's most recent revision of classification and terminology, the term idiopathic epilepsy, previously used to describe those epilepsies whose cause was unknown, but presumed genetic, has been removed. It has been replaced by the term genetic epilepsy, only to be used to describe epilepsy in which the etiology ...
William B, Gallentine, Mohamad A, Mikati
openaire   +2 more sources

Genetic Polymorphisms and Idiopathic Generalized Epilepsies

Pediatric Neurology, 2007
In recent years, progress in understanding the genetic basis of idiopathic generalized epilepsies has proven challenging because of their complex inheritance patterns and genetic heterogeneity. Genetic polymorphisms offer a convenient avenue for a better understanding of the genetic basis of idiopathic generalized epilepsy by providing evidence for the
Lucarini, Nazzareno, Verrotti, Alberto, Napolioni, Valerio, Bosco, Guido, Curatolo, Paolo   +4 more
openaire   +6 more sources