Results 181 to 190 of about 27,030 (251)

Feasibility and signal quality of the Minder® implantable continuous EEG monitoring® system compared to 10–20 scalp electrodes over extended monitoring periods

Epilepsia, EarlyView.
Abstract Objective To evaluate the signal quality of the Minder implantable continuous EEG monitoring (iCEM) system compared to traditional scalp EEG in the context of long‐term, continuous monitoring in individuals with epilepsy. Methods Twenty‐six patients implanted with the Minder iCEM system (November 2019 to July 2023) underwent 7‐day video‐EEG co‐
Taneeta Mindy Ganguly, Alan Lai, Andrew Niemiec, Tracy Cameron, Erin C. Conrad, Ramya Raghupathi, Colin Ellis, Amy J. Halliday, Lisa Gillinder, Udaya Seneviratne, Patrick Kwan, Piero Perucca, Aileen McGonigal, Sara Vogrin, Holly Fontenot, Mark J. Cook   +15 more
wiley   +1 more source

Low diagnostic yield of presurgical genetic testing in adult patients with epilepsy

Epilepsia, EarlyView.
Abstract Objective To determine the diagnostic yield of genetic testing in patients undergoing presurgical evaluation for epilepsy. Methods We conducted a cohort study including 115 adult patients who underwent presurgical evaluation in the Calgary Epilepsy Program between 2019 and 2023 and who had undergone research exome sequencing.
Clara Jünemann, Amanda Stuart, Navprabhjot Kaur, Samuel Wiebe, Nathalie Jette, Shaily Singh, Felippe Borlot, Susanne Knake, The Calgary Comprehensive Epilepsy Program Collaborators, Paolo Federico, Colin Josephson, William Murphy, Andrea Salmon, Guillermo Delgado Garcia, Walter Hader, Ping Yee Billie Au, Karl Martin Klein   +16 more
wiley   +1 more source

Disruption of functional gradients in genetic generalized epilepsy and its clinical relevance: evidence from high-density EEG

Zhang J, Rigoni I, Van De Ville D, Vulliémoz S, Roehri N.   +4 more
europepmc   +1 more source

Thalamic volume reduction in drug-naive patients with new-onset genetic generalized epilepsy. [PDF]

Epilepsia, 2018
Perani S, Tierney TM, Centeno M, Shamshiri EA, Yaakub SN, O'Muircheartaigh J, Carmichael DW, Richardson MP.   +7 more
europepmc   +1 more source

Seizure relapse in new onset epilepsy: It is not always drug resistance

Epilepsia, EarlyView.
Abstract Objective Seizure recurrence in new onset epilepsy (NOE) can result from various factors. Although drug ineffectiveness is frequently investigated, other causes—such as nonadherence, inadequate treatment, nonepileptic events (e.g., functional/dissociative), or acute symptomatic seizures—also impact patient outcomes.
Cecilia Catania, Eric Menetre, Aikaterini Fitsiori, Felix Tobias Kurz, Gabriela Moreno Legast, Serge Vulliemoz, Mathieu Genoud, Pierre Mégevand, Roland Wiest, Fabienne Picard, Sandor Beniczky, Margitta Seeck   +11 more
wiley   +1 more source

Functional variants in HCN4 and CACNA1H may contribute to genetic generalized epilepsy. [PDF]

Epilepsia Open, 2017
Becker F, Reid CA, Hallmann K, Tae HS, Phillips AM, Teodorescu G, Weber YG, Kleefuss-Lie A, Elger C, Perez-Reyes E, Petrou S, Kunz WS, Lerche H, Maljevic S.   +13 more
europepmc   +1 more source

A translational multimodal machine‐learning prototype predicting valproate response in epilepsy treatment

Epilepsia, EarlyView.
Abstract Objective Epilepsy affects ~1% of the global population and often requires lifelong antiseizure medication (ASM) therapy. Valproic acid (VPA) is a commonly prescribed first‐line ASM, yet only approximately half of patients achieve sustained seizure freedom. Treatment selection remains largely empirical.
Simeon Platte, Afsheen Kumar, Giorgia Guerini, Massimo Pandolfo, Denise Haslinger, Colin B. Josephson, Guillermo Delgado‐García, Navprabhjot Kaur, Michaela‐Pauline Lux, Heiko Stempfle, Chantal Depondt, Reetta Kälviäinen, Felix Rosenow, Sophie von Brauchitsch, Karl Martin Klein, Andreas G. Chiocchetti   +15 more
wiley   +1 more source

Unravelling the brain networks driving spike-wave discharges in genetic generalized epilepsy-common patterns and individual differences. [PDF]

Epilepsia Open, 2018
Klamer S, Ethofer T, Torner F, Sahib AK, Elshahabi A, Marquetand J, Martin P, Lerche H, Erb M, Focke NK.   +9 more
europepmc   +1 more source

Long‐term prognosis of pharmacotherapy in newly diagnosed focal epilepsy patients and the predictive value of baseline seizure timing: A prospective cohort study

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a highly heterogeneous neurological disorder with significant prognostic variability. Accurate long‐term outcome prediction remains a clinical challenge. We investigated pharmacotherapeutic prognosis and key predictors, particularly baseline seizure timing, to guide individualized treatment.
Lei Sun, Shouye Sun, Xinyue Zhang, Weihong Lin   +3 more
wiley   +1 more source

Efficacy and tolerability of perampanel in patients with genetic generalized epilepsy (GGE): A retrospective, single-center study from the United Arab Emirates (UAE). [PDF]

Epilepsy Behav Rep, 2019
Alsaadi T, Kassie SA, Servano R.
europepmc   +1 more source