Results 21 to 30 of about 27,030 (251)
Sahel Medical Journal, 2016 Until recently, genetic generalized epilepsy (GGE) was believed to be of presumed genetic etiology with no identifiable genetic mutation or demonstrable epigenetic abnormality. A wide range of epileptic disorders has clue for an inherited susceptibility.
S A Balarabe, M M Watila
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Neurological Sciences and Neurophysiology, 2021 Introduction: Idiopathic generalized epilepsies (IGEs) include four different epilepsy syndromes and IGE have mostly a good response to antiepileptic drugs (AEDs). The most common IGE subgroup is juvenile myoclonic epilepsy (JME).
Fulya Eren, Günay Gül
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Genetic Causes of Generalized Epilepsies [PDF]
Seminars in Neurology, 2015 Generalized epilepsies, particularly the idiopathic or genetic generalized epilepsies (GGEs), represent some of the most common epilepsies. Clinical genetic data including family studies and twin studies provide compelling evidence for a prominent genetic impact.
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The role of thalamic nuclei in genetic generalized epilepsies
Epilepsy Research, 2022 There is no doubt on the participation of the thalamus in the various types of genetic generalized epilepsies as evidenced by multiple non-invasive imaging studies in humans as well as invasive studies in animal models of GGE. Based on human and mostly animal data gathered in early 2000 a so called 'three compartment model' on seizure generation was ...
Luttjohann, A.K. +2 more
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Saudi Pharmaceutical Journal, 2019 Background: Pharmacotherapy of epilepsy including antiepileptic drugs (AEDs) is one of the main treatment approaches. As a biological target, sodium channels (Nav channels) and glutamate receptor genes are playing a major role in the etiology and ...
Laith N. AL-Eitan +2 more
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Electroencephalography in the Diagnosis of Genetic Generalized Epilepsy Syndromes. [PDF]
Front Neurol, 2017 Genetic generalized epilepsy (GGE) consists of several syndromes diagnosed and classified on the basis of clinical features and electroencephalographic (EEG) abnormalities. The main EEG feature of GGE is bilateral, synchronous, symmetric, and generalized spike-wave complex.
Seneviratne U, Cook MJ, D'Souza WJ.
europepmc +6 more sources
Genetics of Idiopathic Generalized Epilepsies [PDF]
Epilepsia, 2005 Summary: The idiopathic generalized epilepsies (IGEs) are considered to be primarily genetic in origin. They encompass a number of rare mendelian or monogenic epilepsies and more common forms which are familial but manifest as complex, non‐mendelian traits. Recent advances have demonstrated that many monogenic IGEs are ion channelopathies.
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Generalized epilepsies: current conceptions and therapeutic approaches
Неврология, нейропсихиатрия, психосоматика, 2012 The concepts of generalized epilepsy have recently undergone considerable changes: the features of focality in generalized epilepsies and the typical features of idiopathic generalized epilepsies in focal epilepsies have been revealed.
L R Zenkov
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Epilepsy & Behavior Reports, 2021 We report a patient with a 6q22.1 deletion, who presented with a rare syndrome of generalized epilepsy, myoclonic tremor, and intellectual disability. There was no clinical progression after follow-up for more than 10 years.
Kazuhiro Haginoya +11 more
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Genetic epilepsy with febrile seizures plus – an overview [PDF]
Romanian Journal of Neurology, 2021 Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by a group of genetic epilepsies associated predominately with an autosomal dominant pattern, but also with de novo and autosomal-recessive inheritance, these last two found in a small ...
Madalina Radu +3 more
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