Results 41 to 50 of about 28,537 (282)
Saudi Pharmaceutical Journal, 2019 Background: Pharmacotherapy of epilepsy including antiepileptic drugs (AEDs) is one of the main treatment approaches. As a biological target, sodium channels (Nav channels) and glutamate receptor genes are playing a major role in the etiology and ...
Laith N. AL-Eitan +2 more
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Epilepsy & Behavior Reports, 2021 We report a patient with a 6q22.1 deletion, who presented with a rare syndrome of generalized epilepsy, myoclonic tremor, and intellectual disability. There was no clinical progression after follow-up for more than 10 years.
Kazuhiro Haginoya +11 more
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Genetic epilepsy with febrile seizures plus – an overview [PDF]
Romanian Journal of Neurology, 2021 Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by a group of genetic epilepsies associated predominately with an autosomal dominant pattern, but also with de novo and autosomal-recessive inheritance, these last two found in a small ...
Madalina Radu +3 more
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Genetics of Idiopathic Generalized Epilepsies [PDF]
Epilepsia, 2005 Summary: The idiopathic generalized epilepsies (IGEs) are considered to be primarily genetic in origin. They encompass a number of rare mendelian or monogenic epilepsies and more common forms which are familial but manifest as complex, non‐mendelian traits. Recent advances have demonstrated that many monogenic IGEs are ion channelopathies.
openaire +2 more sources
The role of thalamic nuclei in genetic generalized epilepsies
Epilepsy Research, 2022 There is no doubt on the participation of the thalamus in the various types of genetic generalized epilepsies as evidenced by multiple non-invasive imaging studies in humans as well as invasive studies in animal models of GGE. Based on human and mostly animal data gathered in early 2000 a so called 'three compartment model' on seizure generation was ...
Luttjohann, A.K. +2 more
openaire +4 more sources
Generalized epilepsies: current conceptions and therapeutic approaches
Неврология, нейропсихиатрия, психосоматика, 2012 The concepts of generalized epilepsy have recently undergone considerable changes: the features of focality in generalized epilepsies and the typical features of idiopathic generalized epilepsies in focal epilepsies have been revealed.
L R Zenkov
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Electroencephalography in the Diagnosis of Genetic Generalized Epilepsy Syndromes. [PDF]
Front Neurol, 2017 Genetic generalized epilepsy (GGE) consists of several syndromes diagnosed and classified on the basis of clinical features and electroencephalographic (EEG) abnormalities. The main EEG feature of GGE is bilateral, synchronous, symmetric, and generalized spike-wave complex.
Seneviratne U, Cook MJ, D'Souza WJ.
europepmc +6 more sources
Unmasking of myoclonus by lacosamide in generalized epilepsy
Epilepsy and Behavior Case Reports, 2017 Lacosamide is a new-generation antiseizure medication that is approved for use as an adjunctive treatment and monotherapy in focal epilepsy. Its use in generalized epilepsy, however, has not been adequately evaluated in controlled trials.
Daniel Birnbaum, Mohamad Koubeissi
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Antisaccades and memory-guided saccades in genetic generalized epilepsy and temporal lobe epilepsy
, 2021 Objective: Oculomotor tasks can be used to measure volitional control of behavior sensitive to frontal dysfunction. This study aimed to examine the saccadic eye movement in Genetic Generalized Epilepsy (GGE) which could correlate with the abnormality of ...
Guerrero-Molina, María Paz +8 more
core +1 more source
Heliyon, 2022 Objective: Estimate sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of EEG findings: centrotemporal spikes, photoparoxysmal response, asymmetric photic driving, and asymmetric sleep spindles, for epilepsy ...
Mohammed Ashour +6 more
doaj +1 more source