Results 31 to 40 of about 2,936,182 (239)

Unmasking of myoclonus by lacosamide in generalized epilepsy

Epilepsy and Behavior Case Reports, 2017
Lacosamide is a new-generation antiseizure medication that is approved for use as an adjunctive treatment and monotherapy in focal epilepsy. Its use in generalized epilepsy, however, has not been adequately evaluated in controlled trials.
Daniel Birnbaum, Mohamad Koubeissi
doaj   +1 more source

Antisaccades and memory-guided saccades in genetic generalized epilepsy and temporal lobe epilepsy

, 2021
Objective: Oculomotor tasks can be used to measure volitional control of behavior sensitive to frontal dysfunction. This study aimed to examine the saccadic eye movement in Genetic Generalized Epilepsy (GGE) which could correlate with the abnormality of ...
Guerrero-Molina, María Paz, Uriarte-Pérez de Urabayen, David, Garzo-Caldas, Nicolás, García Cena, Cecilia, Rodriguez-López, Claudia, Panadés-de Oliveira, Luisa, Saiz-Díaz, Rosa A., Benito-León, Julián, González de la Aleja, Jesús, Cecilia E. García-Cena, David Uriarte-Pérez de Urabayen, María Paz Guerrero-Molina, Luisa Panadés-de Oliveira, García-Cena, Cecilia E., Julián Benito-León, Nicolás Garzo-Caldas, Claudia Rodriguez-López, Rosa A. Saiz-Díaz, Jesús Gonzalez de la Aleja   +18 more
core   +1 more source

Are Generalized and Localization-Related Epilepsies Genetically Distinct? [PDF]

Archives of Neurology, 1998
Whether the genetic influences are distinct for generalized and localization-related epilepsies or whether some susceptibility genes raise the risk for both types of epilepsy is uncertain.To evaluate genetic heterogeneity in epilepsy.We used Cox proportional hazards analysis to compute rate ratios (RRs) for generalized and localization-related ...
R, Ottman, J H, Lee, W A, Hauser, N, Risch   +3 more
openaire   +2 more sources

Analysis of GABRG2 C588T polymorphism in genetic epilepsy and evaluation of GABRG2 in drug treatment

Clinical and Translational Science, 2021
Epilepsy is a common disorder with complex inheritance, and its treatment is very unsatisfactory. An association between the GABRG2 C588T polymorphism and genetic generalized epilepsy has been studied by several genetic association studies.
Shitao Wang, Xianjun Zhang, Liang Zhou, Qian Wu, Yanbing Han   +4 more
doaj   +1 more source

Genetic generalized epilepsy and generalized onset seizures with focal evolution (GOFE)

Epilepsy & Behavior Reports, 2022
“Generalized Onset with Focal Evolution” (GOFE) is an underrecognized seizure type defined by an evolution from generalized onset to focal activity during the same ictal event. We aimed to discuss electroclinical aspects of GOFE and to emphasize its link
Florian Lamy, Maria-Paola Valenti-Hirsch, Lucas Gauer, Bénédicte Gérard, Mohamed Obeid, Anne de Saint-Martin, Vera Dinkelacker, Sarah Baer, Edouard Hirsch   +8 more
doaj   +1 more source

Electroencephalography in the Diagnosis of Genetic Generalized Epilepsy Syndromes [PDF]

Frontiers in Neurology, 2017
Genetic generalized epilepsy (GGE) consists of several syndromes diagnosed and classified on the basis of clinical features and electroencephalographic (EEG) abnormalities. The main EEG feature of GGE is bilateral, synchronous, symmetric, and generalized spike-wave complex.
Udaya Seneviratne, Udaya Seneviratne, Mark J. Cook, Wendyl Jude D’Souza   +3 more
openaire   +4 more sources

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Diagnostic utility of specific abnormal EEG patterns in children for determining epilepsy phenotype and presence of structural brain abnormalities

Heliyon, 2022
Objective: Estimate sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of EEG findings: centrotemporal spikes, photoparoxysmal response, asymmetric photic driving, and asymmetric sleep spindles, for epilepsy ...
Mohammed Ashour, Erica Minato, Abdulla Alawadhi, Saoussen Berrahmoune, Elisabeth Simard-Tremblay, Chantal Poulin, Kenneth A. Myers   +6 more
doaj   +1 more source

Whole Genome Sequence Data From Captive Baboons Implicate RBFOX1 in Epileptic Seizure Risk

Frontiers in Genetics, 2021
In this study, we investigate the genetic determinants that underlie epilepsy in a captive baboon pedigree and evaluate the potential suitability of this non-human primate model for understanding the genetic etiology of human epilepsy.
Mark Z. Kos, Melanie A. Carless, Melanie A. Carless, Lucy Blondell, M. Michelle Leland, Koyle D. Knape, Harald H. H. Göring, Charles Ákos Szabó, Charles Ákos Szabó   +8 more
doaj   +1 more source

CLINICAL AND GENETIC HETEROGENITY OF JUVENILE MYOCLONIC EPILEPSY

Эпилепсия и пароксизмальные состояния, 2016
The idiopathic generalized epilepsies constitute roughly one-third of all epilepsies. Juvenile myoclonic epilepsy (Janz syndrome) is characterized by myoclonic jerks on awakening, generalized tonic-clonic seizures, and typical absences, with the latter ...
N. A. Shnayder, O. S. Shilkina, K. V. Petrov, I. A. Chernykh, A. V. Diuzhakova   +4 more
doaj   +1 more source