Results 221 to 230 of about 3,275,705 (300)

Deep genome sequencing reveals extensive genetic heterogeneity in early human placentas. [PDF]

Nat Commun
Miceikaite I, Fagerberg C, Brasch-Andersen C, Torring PM, Schlott Kristiansen B, Hao Q, Sperling L, Larsen MJ.   +7 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Unraveling the Genetic Heterogeneity of Isolated Growth Hormone Deficiency: Insights from the GENHYPOPIT Cohort.

Horm Res Paediatr
Aouchiche K, Romanet P, Charnay T, Barlier A, Roche C, Grunenwald S, Le Collen L, Porques Bordes V, Barat P, Castinetti F, Brue T, Reynaud R, Saveanu A.   +12 more
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Genetic heterogeneity in childhood leukemia/lymphoma: a Turkish cohort with strong predisposition. [PDF]

Front Genet
Onder G, Ozdemir O, Taylan F, Canpolat C, Yalcin K, Erbey F, Sozmen BO, Asarcikli F, Bayhan T, Akcabelen YM, Yarali N, Ozbek NY, Bozkaya IO, Kacar D, Ergun B, Akkus A, Albayrak D, Ince E, Demirsoy U, Ozdemir GN, Dogru O, Aras S, Aydin E, Unal B, Amanvermez U, Dogan OA, Akyoney S, Sayitoglu M, Nordgren A, Bugra Agaoglu N, Ozbek U, Ng OH.   +31 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

The Causal Pivot: A structural approach to genetic heterogeneity and variant discovery in complex diseases. [PDF]

Am J Hum Genet
Shaw CA, Williams CJ, Tan T, Illera D, Di N, Shulman JM, Belmont JW.   +6 more
europepmc   +1 more source

Design and evaluation of FEBS Education and Training Academy module – Integrating generative artificial intelligence into life‐science education

FEBS Open Bio, EarlyView.
Life‐science educators from 14 countries redesigned their own course materials with generative AI in a three‐session, pedagogy‐first FEBS Education and Training Academy workshop built on PICRAT. Among 12 matched respondents, four more reported high confidence in each of five practical domains, and 10 of 13 reported implementing at least one idea ...
Zvonimir Mlinarić, Ali Burak Özkaya
wiley   +1 more source

Genetic Heterogeneity Correlated with Phenotypic Variability in 48 Patients with Cystic Fibrosis. [PDF]

J Clin Med
Donos MA, Butnariu LI, Anton Păduraru DT, Murgu AM, Rusu C, Pânzaru MC, Popescu R, Țarcă E, Cojocaru E, Ghiga G, Trandafir LM.   +10 more
europepmc   +1 more source