Results 251 to 260 of about 4,320,960 (307)
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The Genetic Heterogeneity of “Schizophrenia”
World Journal of Biological Psychiatry, 2000The main reason for the inconsistent findings in schizophrenia research is the lack of diagnostic conformity. This has not changed markedly following the introduction of modern operational diagnostic systems. Taking schizophrenia as a disease entity or assuming schizophrenia spectrum psychoses to represent a continuum of diseases without any clear ...
E Franzek +2 more
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Genetic heterogeneity: Challenges, impacts, and methods through an associative lens
Genetic Epidemiology, 2022 Genetic heterogeneity describes the occurrence of the same or similar phenotypes through different genetic mechanisms in different individuals. Robustly characterizing and accounting for genetic heterogeneity is crucial to pursuing the goals of precision
Alexa A. Woodward +3 more
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An analysis of genetic heterogeneity in untreated cancers
Nature Reviews Cancer, 2019 Genetic intratumoural heterogeneity is a natural consequence of imperfect DNA replication. Any two randomly selected cells, whether normal or cancerous, are therefore genetically different.
Martin Nowak +2 more
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Resolving genetic heterogeneity in cancer
Nature Reviews Genetics, 2019Andrea Sottoriva +2 more
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Quantifying between‐cohort and between‐sex genetic heterogeneity in major depressive disorder
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2019 Major depressive disorder (MDD) is clinically heterogeneous with prevalence rates twice as high in women as in men. There are many possible sources of heterogeneity in MDD most of which are not measured in a sufficiently comparable way across study ...
Ian Jones, , Naomi R Wray
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Genetic heterogeneity in Leigh syndrome: Highlighting treatable and novel genetic causes
Clinical Genetics, 2020Leigh syndrome (LS), the most common childhood mitochondrial disorder, has characteristic clinical and neuroradiologic features. Mutations in more than 75 genes have been identified in both the mitochondrial and nuclear genome, implicating a high degree ...
Jin Sook Lee +9 more
semanticscholar +1 more source
Genetic heterogeneity in acatalasemia
ELECTROPHORESIS, 1996Abstract203 bp long products containing exon 4 and its juntions from the catalase gene were generated by polymerase chain reaction (PCR). These products were analyzed by single strand conformational polymorphism (SSCP), heteroduplex formation and nucleotide sisters, their family members and normocatalasemic controls were analyzed. Sequence analyses did
L, Góth, A, Páy
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Genetic counseling and genetic heterogeneity in the thalassemias
Clinical Genetics, 1985In this study, we have compared the hemoglobin A2 levels (Hb A2) of α‐thalassemia carriers (‐α/‐α and ‐α/αα genotypes) with those of double heterozygotes for δ+ and β° thalassemia genes, who were identified by family studies and polymorphic restriction site analysis within the β‐globin gene cluster.
E, Paglietti +3 more
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The Genetic Heterogeneity of Uterine Leiomyomata
Obstetrics and Gynecology Clinics of North America, 2006Research investigating the genetics of UL has already been successful in gathering epidemiologic evidence for heritability, establishing the clonal and mosaic nature of these tumors, correlating genotypic and phenotypic characteristics, defining cytogenetic subgroups, and identifying specific genes involved in tumorigenesis. Although UL are known to be
Lobel, Melissa K +2 more
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