Results 181 to 190 of about 2,328,313 (310)

Systems Genetic Identification of Mitochondrion-Associated Alzheimer's Disease Genes and Implications for Disease Risk Prediction. [PDF]

Biomedicines, 2022
Xu X, Xu X, Wang H, Bennett DA, Zhang QY, Wang G, Zhang HY.   +6 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Genetic Identification of Lamprey Genera and Anadromous Ecotypes in Watersheds of the Northeastern Pacific Ocean. [PDF]

Evol Appl
Silver GS, Lampman RT, Percival N, Timoshevskaya N, Smith JJ, Bentley KT, Wade J, Narum SR, Hess JE.   +8 more
europepmc   +1 more source

Genetic identification of preoptic neurons that regulate body temperature in mice. [PDF]

Temperature (Austin), 2022
Machado NLS, Saper CB.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Genetic identification of gastrointestinal parasites in the world's most endangered ungulate, the hirola (Beatragus hunteri). [PDF]

Vet Rec
Remesar S, García-Dios D, Forcina G, Ali AH, Ndunda M, Jowers MJ.   +5 more
europepmc   +1 more source

First Molecular Identification of Fasciola gigantica in Slaughtered Cattle in Cape Verde: Prevalence, Gross Pathological Lesions, Genetic Identification and Coprological Analysis. [PDF]

Pathogens, 2023
Levy S, Calado M, Mateus TL, Vieira-Pinto M.   +3 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

First case of Trichophyton indotineae in Brazil: clinical and mycological criteria and genetic identification of terbinafine resistance. [PDF]

An Bras Dermatol
Veasey JV, Gonçalves RDJ, Valinoto GCJ, Carvalho GSM, Celestrino GA, Reis APC, Lima APC, Costa ACD, Melhem MSC, Benard G, Sousa MGT.   +10 more
europepmc   +1 more source

Genetic Identification of Edible Bird's Nest in Thailand Based on ARMS-PCR. [PDF]

Front Genet, 2021
Lv D, Fan Y, Zhong W, Lonan P, Liu K, Wu M, Wu Y, Liang Y, Lai X, Li G, Yu L.   +10 more
europepmc   +1 more source