Results 181 to 190 of about 7,102,789 (361)

GENETIC SPECTRUM OF NOONAN SYNDROME IN PEDIATRIC POPULATION [PDF]

Noonan syndrome (NS) is an autosomal dominant hereditary disorder with a prevalence of 1:1000 to 1:2500 live births. First described in 1963 by pediatric cardiologist Jacqueline Noonan, this syndrome is classified among RASopathies which arise from ...
Sarajlija, Adrijan, Gašić, Vladimir, Alimpić, Biljana, Pavlović, Sonja, Ilić, Nikola, Krasić, Staša, Vukomanović, Vladislav, Krstić, Jovana   +7 more
core  

A coupled dual reciprocity BEM/Genetic algorithm for identification of blood perfusion parameters [PDF]

, 2009
The paper presents an inverse analysis procedure based on a coupled numerical formulation through which the coefficients describing non-linear thermal properties of blood perfusion may be identified.
Partridge, P W, Wrobel, L C
core  

High-Mountain Tuber Products Improve Selectively the Development and Detoxifying Capacity of Lactobacilli Strains as an Innovative Culture Strategy

Fermentation
The study provides valuable insights into the sustainable utilization of edible tuber peels from the high mountains of the Argentinian Puna, which constitutes promising reserves of bioactive phenolic compounds with the potential to enhance the ...
Cecilia Hebe Orphèe, María Inés Mercado, Fernando Eloy Argañaraz Martínez, Mario Eduardo Arena, Elena Cartagena   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Identification of genetic polymorphisms associated with oesophageal squamous cell carcinoma risk in South Africa [PDF]

, 2013
Includes abstract.Includes bibliographical references.Oesophageal squamous cell carcinoma (OSCC) is a complex disease, determined by the interaction of genetic factors with environmental risk factors. In South Africa, OSCC is a major malignancy occurring
Matejcic, Marco
core  

SYSTEMATICS AND GENOMIC ANALYSIS OF BACTERIA OF THE GENUS AZOTOBACTER [PDF]

Postępy Mikrobiologii, 2021
Monika Kozieł, Anna Gałązka
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

GENETIC SPECTRUM OF PRIMARY DYSLIPIDEMIAS IN CHILDREN - SINGLE CENTER EXPERIENCE [PDF]

Primary dyslipidemias are heterogenous metabolic disorders caused by pathogenic genetic variants. Over 100 genes have been identified that impact lipid metabolism, with familial hypercholesterolemia being the most common form, occurring in the general ...
Sarajlija, Adrijan, Gašić, Vladimir, Alimpić, Biljana, Pavlović, Sonja, Ilić, Nikola, Krasić, Staša, Đorović, Nevena, Vukomanović, Vladislav, Krstić, Jovana   +8 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source