Results 271 to 280 of about 7,102,789 (361)

Detection and genetic identification of Borrelia lusitaniae in questing Ixodes inopinatus tick from Tunisia. [PDF]

Infect Med (Beijing)
Selmi R, Abdi K, Belkahia H, Abdallah MB, Mamlouk A, Kratou M, Said MB, Messadi L.   +7 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Genetic identification of three CITES-listed sharks using a paper-based Lab-on-a-Chip (LOC). [PDF]

PLoS One
Tiktak GP, Gabb A, Brandt M, Diz FR, Bravo-Vásquez K, Peñaherrera-Palma C, Valdiviezo-Rivera J, Carlisle A, Melling LM, Cain B, Megson D, Preziosi R, Shaw KJ.   +12 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes

Nature Biotechnology, 2014
H. B. Nielsen, Mathieu Almeida, A. S. Juncker, S. Rasmussen, Junhua Li, S. Sunagawa, D. Plichta, L. Gautier, A. G. Pedersen, E. Le Chatelier, Eric Pelletier, Ida Bonde, Trine Nielsen, C. Manichanh, Manimozhiyan Arumugam, Jean-Michel Batto, Marcelo B Quintanilha dos Santos, Nikolaj S. Blom, N. Borruel, K. Burgdorf, F. Boumezbeur, F. Casellas, J. Doré, Piotr Dworzynski, F. Guarner, T. Hansen, F. Hildebrand, R. Kaas, Seán Kennedy, Karsten Kristiansen, Jens Roat Kultima, Pierre Leonard, F. Levenez, Ole Lund, Bouziane Moumen, Denis Le Paslier, N. Pons, Oluf Pedersen, Edi Prifti, Junjie Qin, Jeroen Raes, S. Sørensen, Julien Tap, S. Tims, D. Ussery, Takuji Yamada, H Bjørn Mathieu Agnieszka S Simon Junhua Shinichi Da Nielsen Almeida Juncker Rasmussen Li Sunagawa Plic, A. S. Juncker, Manimozhiyan Arumugam, Karsten Kristiansen, Pierre Leonard, P. Renault, Thomas Sicheritz-Pontén, P. Bork, Jun Wang, S. Brunak, S. Ehrlich, A. Jamet, Alexandre Mérieux, Antonella Cultrone, A. Torrejon, B. Quinquis, Christian Bréchot, C. Delorme, C. M'rini, Willem M. de Vos, Emmanuelle Maguin, E. Varela, É. Guédon, Falony Gwen, Florence Haimet, F. Artiguenave, Gaetana Vandemeulebrouck, G. Denariaz, Ghalia Khaci, H. Blottière, Jan Knol, Jean Weissenbach, J. V. H. van Hylckama Vlieg, J. Torben, Julian Parkhill, K. Turner, M. van de Guchte, M. Antolín, Maria Rescigno, M. Kleerebezem, M. Derrien, N. Galleron, Nicolas Sanchez, N. Grarup, P. Veiga, R. Oozeer, R. Dervyn, Séverine Layec, T. Bruls, Yohanan Winogradski, Zoetendal Erwin G, S. Brunak, S. Ehrlich   +98 more
semanticscholar   +1 more source

Molecular Screening and Genetic Identification of Anaplasma platys in Brown Dog Tick (Rhipicephalus sanguineus s. l.) Infested on Stray Dogs in Taiwan. [PDF]

Microorganisms
Chao LL, Ko PY, Shih CM.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Genetic Identification and Technological Potential of Indigenous Lactic Acid Bacteria Isolated from Alheira, a Traditional Portuguese Sausage. [PDF]

Foods
Fernandes N, Faria AS, Carvalho L, Choupina A, Rodrigues C, Gonzales-Barron U, Cadavez V.   +6 more
europepmc   +1 more source