Results 51 to 60 of about 2,328,313 (310)

Impact of aging : sporadic, and genetic risk factors on vulnerability to apoptosis in Alzheimer's disease [PDF]

, 2003
The identification of specific genetic (presenilin-1 [PS1] and amyloid precursor protein [APP] mutations) and environmental factors responsible for Alzheimer's disease (AD) has revealed evidence for a shared pathway of neuronal death.
Czech, Christian, Eckert, Anne, Frölich, Lutz, Kratzsch, Tilmann, Leutner, Silke, Maurer, Konrad, Müller, Walter E., Peters, Jürgen, Pradier, Laurent, Schindowski, Katharina, Steiner, Barbara, Touchet, Natalie   +11 more
core   +1 more source

CYP2F1 genetic polymorphism: Identification of interethnic variations

Xenobiotica, 2007
Since human cytochrome P450 2F1 (CYP2F1) is predominantly expressed in lung tissue and is involved in the metabolism of various pneumotoxicants with potential carcinogenic effects, variations in the nucleotidic sequence of its gene may contribute to interindividual and interethnic differences in the susceptibility to lung tumorigenesis.
Tournel, G., Cauffiez, C., Leclerc, J., Billaut Laden, I., Allorge, D., Chevalier, D., /Migot Nabias, Florence, Kenani, A., Broly, F., Lo Guidice, J. M.   +9 more
openaire   +3 more sources

Genetic identification of fire deaths [PDF]

Forensic Science International: Genetics Supplement Series, 2009
Abstract We investigated whether authentic DNA patterns can be obtained from human bones showing different stages of burning (well-preserved, semi-burned, black burned, blue-grey burned, blue-grey-white burned) by comparing STR-analysis, mitochondrial SNP-analysis and mitochondrial sequencing. Altogether, 71 bone fragments from 13 fire victims showing
Anke Heinrich, Thorsten Schwark, Eva Simeoni, Nicole von Wurmb-Schwark   +3 more
openaire   +1 more source

Evaluation of the Utility of Baseline Echocardiogram in Patients With Standard Risk Precursor B‐Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
Abstract Background A routine baseline echocardiogram is often obtained prior to anthracycline administration in children with cancer. The utility of baseline echocardiogram is unclear in patients with standard risk B‐cell acute lymphoblastic leukemia (SR B‐ALL) as their anthracycline cumulative dose is low.
Ziyad Alrajhi, Alice Pozza, Luc Mertens, Adam Paul Yan, Sarah Alexander   +4 more
wiley   +1 more source

Draft Genome Sequence of Rhodococcus sp. Strain ATCC 49988, a Quinoline-Degrading Bacterium. [PDF]

, 2019
We report here the 4.9-Mb genome sequence of a quinoline-degrading bacterium, Rhodococcus sp. strain ATCC 49988. The draft genome data will enable the identification of genes and future genetic modification to enhance traits relevant to heteroaromatic ...
Edirisinghe, Janaka N, Faria, José P, Gilbert, Jack A, Gottel, Neil R, Gupta, Nidhi, Henry, Christopher S, Marshall, Christopher W, O'Loughlin, Edward J, Sharma, Anukriti, Skinner, Kelly A, Summers, Zarath M   +10 more
core  

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender, Lauren Pommert, Lori R. Backus, Andrea Bidwell, Courtney Blank, Erin H. Breese, Karen C. Burns, Adam Lane, Lynn H. Lee, Benjamin Mizukawa, Robin E. Norris, Maureen M. O'Brien, Daniel Peck, Christine Phillips, Thomas D. Ryan, Jennifer Young, Michael Absalon, John P. Perentesis   +17 more
wiley   +1 more source

The genetic architecture underlying the evolution of a rare piscivorous life history form in brown trout after secondary contact and strong introgression [PDF]

, 2018
Identifying the genetic basis underlying phenotypic divergence and reproductive isolation is a longstanding problem in evolutionary biology. Genetic signals of adaptation and reproductive isolation are often confounded by a wide range of factors, such as
Adams, Colin E., Elmer, Kathryn R., Hughes, Martin R., Jacobs, Arne, Robinson, Paige C.   +4 more
core   +2 more sources

Incidence and Risk Factors of Serious Osteonecrosis in Pediatric Acute Lymphoblastic Leukemia: A CYP‐C Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteonecrosis (ON) is a debilitating complication of acute lymphoblastic leukemia (ALL) therapy. While numerous studies have explored its incidence and associated risk factors, investigations using large‐scale cohorts remain important to characterize ON across heterogeneous populations.
Noémie de Villiers, Chantal Éthier, Caroline Laverdière, Nathalie Alos, Thai Hoa Tran, Marie‐Claude Pelland‐Marcotte   +5 more
wiley   +1 more source

A novel mathematical framework for pedigree-based calculation of Y-STR match probabilities

Scientific Reports
Y-chromosomal short tandem repeat (Y-STR) markers are routinely used in forensic casework to identify male donors of biological traces left at crime scenes, particularly in sexual assault cases.
Amke Caliebe, Dion Zandstra, Arwin Ralf, Manfred Kayser, Michael Krawczak   +4 more
doaj   +1 more source

Environmental DNA surveys can determine in-stream dominance of non-native brook charr Salvelinus fontinalis over native brown trout Salmo trutta

Ecological Indicators
For effective management of established potentially invasive species it is important to find management target sites (e.g. for depletion or eradication measures). In Sweden, the brook charr is non-native and competes with the native brown trout.
Andreas Broman, William F. Englund, Niclas Gyllenstrand, Joacim Näslund   +3 more
doaj   +1 more source