Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Core circadian clock and light signaling genes brought into genetic linkage across the green lineage. [PDF]
Plant Physiol, 2022 Michael TP.
europepmc +1 more source
Combined Linkage Disequilibrium and Linkage Analysis (cLDLA): implementation of a powerful approach to identify the genetic basis of complex traits in a bioinformatics workflow [PDF]
Maulik Upadhyay +2 more
openalex +1 more source
Investigating the Mendelian inheritance, genetic linkage, and genotypic disequilibrium for ten microsatellite loci of Araucaria angustifolia [PDF]
, 2014 Luciano Medina-Macedo +4 more
openalex +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Construction of ultra-high-density genetic linkage map of a sorghum-sudangrass hybrid using whole genome resequencing. [PDF]
PLoS One, 2022 Lu Q +5 more
europepmc +1 more source
Construction and integration of genetic linkage maps from three multi-parent advanced generation inter-cross populations in rice [PDF]
, 2020 Pingping Qu +9 more
openalex +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Evaluation of antibiotic resistance, toxin-antitoxin systems, virulence factors, biofilm-forming strength and genetic linkage of Escherichia coli strains isolated from bloodstream infections of leukemia patients. [PDF]
BMC Microbiol, 2023 Roshani M +4 more
europepmc +1 more source