Results 181 to 190 of about 1,070,803 (312)

Risk Factors and Genetic Markers Associated with the Development and Progression of Glaucoma: A Review. [PDF]

J Curr Glaucoma Pract
Hamid SAT, Abdulmajeed SM, Chowdhury IH, Hasan MM, Noman SM.   +4 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Genetic Marker [PDF]

, 2019
openaire   +3 more sources

Antimicrobial-Resistance Genetic Markers Among Multidrug-Resistant Enterobacteriaceae and <i>Acinetobacter</i> spp. From Vegetable Market Chains in Ethiopia. [PDF]

Food Sci Nutr
Tesfaye H, Desta AF, Reis A, Egin M, Ozgumus OB, Akarsu N, Abdulkadir M, Alemayehu H, Eguale T, Kilic AO.   +9 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Conserved genetic markers reveal widespread diatom sexual reproduction in the global ocean. [PDF]

Nat Commun
Bilcke G, Campese L, Annunziata R, Amadei Martínez L, Borgonuovo C, Rijsdijk N, Chaerle P, Van den Berge K, D'hondt S, Iudicone D, Montresor M, Ferrante MI, Vandepoele K, Vyverman W.   +13 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Identification of genetic markers associated with coronary artery disease in Pakistani Pashtun population: A case-control association study. [PDF]

Medicine (Baltimore)
Jan A, Ullah A, Khattak M, Shah WA, Akbar R, Nahla UA.   +5 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Molecular and Genetic Markers for Malignant Melanoma: Implications for Prognosis and Therapy. [PDF]

Dermatopathology (Basel)
Fleshner L, Sayegh A, Atak MF, Hirani R, Farabi B, Safai B, Marmon S.   +6 more
europepmc   +1 more source