Results 181 to 190 of about 1,685,362 (303)

Molecular and Genetic Markers for Malignant Melanoma: Implications for Prognosis and Therapy. [PDF]

Dermatopathology (Basel)
Fleshner L, Sayegh A, Atak MF, Hirani R, Farabi B, Safai B, Marmon S.   +6 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Genetic markers and canonical pathways associated with medulloblastoma: a systematic review and meta-analysis. [PDF]

Transl Pediatr
Le K, Voskamp S, Sharma V, Nelson J, Agarwal V.   +4 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Genetic Markers for Tracing Introgression of Farmed Atlantic Salmon (Salmo salar) in Wild Conspecifics. [PDF]

Mol Ecol Resour
Hagen IJ, Hindar K, Bolstad GH, Czorlich Y, Diserud OH, Florø-Larsen B, Gíslason D, Glover K, Guðmundsson LA, Jacq C, Ólafsdóttir G, Omholt SW, Solberg MF, Sveinsson S, Sægrov H, Urdal K, Karlsson S.   +16 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Genomic characterization and sub-clustering of Escherichia coli clonal complex 38 reveal host associated genetic markers. [PDF]

Commun Med (Lond)
Roer L, Rasmussen A, Hansen F, Christoffersen LEB, Sieber R, Scheutz F, Hendriksen RS, Johnston BD, Johnson JR, Holzknecht BJ, Søes L, Schønning K, Holmgaard DB, Justesen US, Østergaard C, Søndergaard TS, Nielsen MTK, Wang M, Nielsen HL, Abraham S, Park DE, Aziz M, Price LB, Hammerum AM, Hasman H, Stegger M.   +25 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Development and Characterization of Microsatellite Genetic Markers for <i>Hyalomma rufipes</i>, a Tick Vector of Crimean-Congo Hemorrhagic Fever Virus. [PDF]

Ecol Evol
Ahmad H, Aool W, Anyango V, Nakayaki TM, Mulwa F, Chelangat B, Lutwama JJ, Kayondo JK, Lukindu M, Mutisya J, Lutomiah J, Hensley LE, Cohnstaedt LW, Onyango MG, Brelsfoard CL.   +14 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source