Results 191 to 200 of about 1,070,803 (312)

Simple Algorithms to Calculate Asymptotic Null Distributions of Robust Tests in Case-Control Genetic Association Studies in R

The case-control study is an important design for testing association between genetic markers and a disease. The Cochran-Armitage trend test (CATT) is one of the most commonly used statistics for the analysis of case-control genetic association studies ...
Wing Kam Fung, Yong Zang, Gang Zheng
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Quantification of root biomass in barley variety mixtures using variety-specific genetic markers. [PDF]

Plant Methods
Suizu M, Lindahl BD, Müller CW, Keller T, Colombi T.   +4 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Genetic markers and canonical pathways associated with medulloblastoma: a systematic review and meta-analysis. [PDF]

Transl Pediatr
Le K, Voskamp S, Sharma V, Nelson J, Agarwal V.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Genetic Markers for Tracing Introgression of Farmed Atlantic Salmon (Salmo salar) in Wild Conspecifics. [PDF]

Mol Ecol Resour
Hagen IJ, Hindar K, Bolstad GH, Czorlich Y, Diserud OH, Florø-Larsen B, Gíslason D, Glover K, Guðmundsson LA, Jacq C, Ólafsdóttir G, Omholt SW, Solberg MF, Sveinsson S, Sægrov H, Urdal K, Karlsson S.   +16 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Genomic characterization and sub-clustering of Escherichia coli clonal complex 38 reveal host associated genetic markers. [PDF]

Commun Med (Lond)
Roer L, Rasmussen A, Hansen F, Christoffersen LEB, Sieber R, Scheutz F, Hendriksen RS, Johnston BD, Johnson JR, Holzknecht BJ, Søes L, Schønning K, Holmgaard DB, Justesen US, Østergaard C, Søndergaard TS, Nielsen MTK, Wang M, Nielsen HL, Abraham S, Park DE, Aziz M, Price LB, Hammerum AM, Hasman H, Stegger M.   +25 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source