Results 51 to 60 of about 5,022,316 (352)

Identification of Novel Genetic Markers of Breast Cancer Survival

Journal of the National Cancer Institute, 2015
Background: Survival after a diagnosis of breast cancer varies considerably between patients, and some of this variation may be because of germline genetic variation.
Qi Guo, M. Schmidt, P. Kraft, S. Canisius, Constance Chen, Sofia Khan, J. Tyrer, M. Bolla, Qin Wang, J. Dennis, K. Michailidou, M. Lush, S. Kar, J. Beesley, A. Dunning, M. Shah, K. Czene, Hatef Darabi, M. Eriksson, D. Lambrechts, C. Weltens, K. Leunen, S. Bojesen, B. Nordestgaard, S. F. Nielsen, H. Flyger, J. Chang-Claude, A. Rudolph, P. Seibold, D. Flesch-Janys, C. Blomqvist, K. Aittomäki, R. Fagerholm, T. Muranen, F. Couch, J. Olson, C. Vachon, I. Andrulis, J. Knight, G. Glendon, A. Mulligan, A. Broeks, F. Hogervorst, C. Haiman, B. Henderson, F. Schumacher, L. Le Marchand, J. Hopper, H. Tsimiklis, C. Apicella, M. Southey, A. Cox, S. Cross, M. Reed, G. Giles, R. Milne, C. Mclean, R. Winqvist, K. Pylkäs, A. Jukkola-Vuorinen, Mervi Grip, M. Hooning, A. Hollestelle, J. Martens, A. V. D. van den Ouweland, F. Marmé, A. Schneeweiss, Rongxi Yang, B. Burwinkel, J. Figueroa, S. Chanock, J. Lissowska, E. Sawyer, I. Tomlinson, M. Kerin, N. Miller, H. Brenner, A. K. Dieffenbach, V. Arndt, B. Holleczek, A. Mannermaa, V. Kataja, V. Kosma, Jaana M. Hartikainen, Jingmei Li, Judith S. Brand, K. Humphreys, P. Devilee, R. Tollenaar, C. Seynaeve, P. Radice, P. Peterlongo, B. Bonanni, P. Mariani, P. Fasching, M. Beckmann, A. Hein, A. Ekici, G. Chenevix-Trench, Rosemary L. Balleine, K. Phillips, J. Benítez, M. P. Zamora, J. A. Arias Perez, P. Menéndez, A. Jakubowska, J. Lubiński, Katarzyna Jaworska–Bieniek, K. Durda, U. Hamann, M. Kabisch, H. Ulmer, T. Rüdiger, S. Margolin, V. Kristensen, Silje Nord, D. Evans, J. Abraham, Helena M Earl, L. Hiller, J. Dunn, S. Bowden, C. Berg, D. Campa, W. Diver, S. Gapstur, M. Gaudet, S. Hankinson, R. Hoover, A. Hüsing, R. Kaaks, M. Machiela, W. Willett, Myrto Barrdahl, F. Canzian, S. Chin, C. Caldas, D. Hunter, S. Lindstrom, M. García-Closas, P. Hall, D. Easton, D. Eccles, N. Rahman, H. Nevanlinna, P. Pharoah   +145 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Etude comparative de la diversité et de la structure génétique de populations sauvages de Phaseolus lunatus L. à l’aide des marqueurs enzymatiques et microsatellites [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2005
Comparative study of genetic diversity and structure of wild Phaseolus lunatus L. populations using enzymatic and microsatellite markers. Genetic diversity within and among Phaseolus lunatus L. var.
Baudoin JP., Ouédraogo M., Maquet A.
doaj  

AFRICAN SWINE FEVER VIRUS: USE OF GENETIC MARKERS IN ANALYSIS OF ITS ROUTES OF SPREAD

Ветеринария сегодня, 2019
At present no effective measures for specific prevention and treatment of African swine fever have been developed. The control strategy for the disease is designed for rapid diagnosis of infected animals with subsequent slaughter and decontamination ...
A. Mazloum, A. S. Igolkin, N. N. Vlasova, D. V. Romenskaya   +3 more
doaj   +1 more source

Exploring Diallelic Genetic Markers: The HardyWeinberg Package

, 2015
Testing genetic markers for Hardy-Weinberg equilibrium is an important issue in genetic association studies. The HardyWeinberg package offers the classical tests for equilibrium, functions for power computation and for the simulation of marker data under
J. Graffelman
semanticscholar   +1 more source

Linkage disequilibrium estimates of contemporary Ne using highly variable genetic markers: a largely untapped resource for applied conservation and evolution

Evolutionary Applications, 2009
Genetic methods are routinely used to estimate contemporary effective population size (Ne) in natural populations, but the vast majority of applications have used only the temporal (two‐sample) method.
R. Waples, C. Do
semanticscholar   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source