Results 151 to 160 of about 942,198 (289)

Genetic Parameter Estimation and Whole Sequencing Analysis of the Genetic Architecture of Chicken Keel Bending. [PDF]

Front Genet, 2022
Zhang Z, Yang W, Zhu T, Wang L, Zhao X, Zhao G, Qu L, Jia Y.   +7 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Comparison of Random Regression Models with Different Order Legendre Polynomials for Genetic Parameter Estimation on Race Completion Speed of Arabian Horses. [PDF]

Animals (Basel), 2022
Önder H, Şen U, Piwczyński D, Kolenda M, Drewka M, Abacı SH, Takma Ç.   +6 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Genetic Parameter Estimation and Genome-Wide Association Analysis of Social Genetic Effects on Average Daily Gain in Purebreds and Crossbreds. [PDF]

Animals (Basel), 2022
Seong HS, Kim YS, Sa SJ, Jeong Y, Hong JK, Cho ES.   +5 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Genetic parameter estimation and genome-wide association study of fiber characteristics for cashmere goats in the United States. [PDF]

J Anim Sci
Dressler EA, Bormann JM, Weaber RL, Merkel RC, Rolf MM.   +4 more
europepmc   +1 more source

Genetic parameter estimation for beef bull semen attributes. [PDF]

J Anim Sci, 2021
Butler ML, Hartman AR, Bormann JM, Weaber RL, Grieger DM, Rolf MM.   +5 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Phenotypic and genetic parameter estimates for early growth, growth rate and growth efficiency-related traits of Fogera cattle in Ethiopia. [PDF]

Vet Med Sci, 2022
Kassahun D, Taye M, Kebede D, Tilahun M, Tesfa A, Bitew A, Kebede A, Meseret M, Lakew E, Bimrow T, Haile A.   +10 more
europepmc   +1 more source