Genetic Predisposition to SARS-CoV-2 Infection: Cytokine Polymorphism and Disease Transmission within Households [PDF]
Biology, 2023 We addressed the question of the influence of the molecular polymorphism of cytokines from different T helper subsets on the susceptibility to SARS-CoV-2 infection. From a cohort of 527 samples (collected from 26 May 2020 to 31 March 2022), we focused on
Marius Saal +4 more
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The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities [PDF]
Nature CommunicationsType 2 diabetes is associated with a range of non-cardiovascular non-oncologic comorbidities. To move beyond associations and evaluate causal effects between type 2 diabetes genetic predisposition and 21 comorbidities, we apply Mendelian randomization ...
Ana Luiza Arruda +18 more
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Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities [PDF]
Alzheimer’s Research & Therapy, 2019 Background Alzheimer’s disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance.
Alireza Nazarian +2 more
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Genetic predisposition to Behcet's disease mediated by a IL10RA enhancer polymorphism
HeliyonBackground: Several studies suggested the genetic association between IL10RA variants and susceptibility to Behcet's disease (BD). However, the precise mechanism of the association is still unknown.
Handan Tan +5 more
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Clinical Pediatric Hematology-Oncology, 2023 Cancer predisposition syndromes (CPS) are a group of genetic disorders that increase the risk of developing various types of cancer. The prevalence of CPS in children has been known to be up to 18-20% based on recent reports.
Jae Won Yoo
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OBESITY AND DYSLIPIDEMIA IN CHILDREN WITH CHRONIC HEPATITIS [PDF]
Romanian Journal of Pediatrics, 2016 Chronic hepatitis association with various types of dyslipidemia is a reality not only for the obese pediatric patient, in which we expect to find hypercholesterolemia and / or hypertriglyceridemias, but also for normal weight children with hepatitis ...
Alice N. Azoicai +7 more
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Germline RUNX1 variants in paediatric patients in a French specialised centre
eJHaem, 2023 Familial platelet disorder with associated myeloid malignancy (FPD‐MM; OMIM 601399) is related to germline RUNX1 mutation. The pathogenicity of RUNX1 variants was initially linked to FPD‐MM phenotype, but the discovery of new variants through the ...
Cécile Liu +10 more
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Apolipoprotein E gene polymorphisms as risk factors for carotid atherosclerosis [PDF]
Vojnosanitetski Pregled, 2014 Background/Aim. Atherosclerosis is still the leading cause of death in Western world. Development of atherosclerotic plaque involves accumulation of inflammatory cells, lipids, smooth muscle cells and extracellular matrix proteins in the intima ...
Zurnić Irena +5 more
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Ethnic differences in adiposity and diabetes risk – insights from genetic studies [PDF]
, 2020 Type 2 diabetes is more common in non-Europeans and starts at a younger age and at lower BMI cut-offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of disease with a focus on the role of
Bell, J.D. +7 more
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Unique Features of Germline Variation in Five Egyptian Familial Breast Cancer Families Revealed by Exome Sequencing. [PDF]
PLoS ONE, 2017 Genetic predisposition increases the risk of familial breast cancer. Recent studies indicate that genetic predisposition for familial breast cancer can be ethnic-specific.
Yeong C Kim +10 more
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