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Genetic Predisposition to Cardiovascular Diseases [PDF]

open access: bronzeInternational Journal of Human Genetics, 2001
Extensive clinical and statistical studies have identified several factors that increase the risk of heart disease, heart attack and stroke. Major risk factors are those that are associated with a significant increase in the risk of heart and blood vessel disease (CVD).
Dharam P. Agarwal
openalex   +3 more sources

Network location and clustering of genetic mutations determine chronicity in a stylized model of genetic diseases [PDF]

open access: yesScientific Reports, 2022
In a highly simplified view, a disease can be seen as the phenotype emerging from the interplay of genetic predisposition and fluctuating environmental stimuli.
Piotr Nyczka   +2 more
doaj   +2 more sources

Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer’s disease [PDF]

open access: goldTranslational Psychiatry, 2021
AbstractAlzheimer’s disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of Alzheimer associated neuropathological changes, and Alzheimer’s disease occurrence within 14 years ...
Hannah Stocker   +10 more
openalex   +6 more sources

Genetic markers of children asthma: predisposition to disease course variants

open access: yesВавиловский журнал генетики и селекции, 2023
Asthma is a heterogeneous and often difficult to treat condition that results in a disproportionate cost to healthcare systems. Children with severe asthma are at increased risk for adverse outcomes including medication-related side effects, life ...
M. V. Smolnikova   +3 more
doaj   +3 more sources

Genetic predisposition to metabolic dysfunction-associated fatty liver disease

open access: diamondZdorovʹe Rebenka
The literature review highlights the issue of genetic risk factors associated with the development of metabolic dysfunction-associated fatty liver disease. Human genetic examinations revealed 132 genes among which 32 loci are strongly associated with the
O.E. Abaturov, A.O. Nikulina
doaj   +3 more sources

Investigating the role of mitochondrial haplogroups in genetic predisposition to meningococcal disease.

open access: yesPLoS ONE, 2009
Background and aimsMeningococcal disease remains one of the most important infectious causes of death in industrialized countries. The highly diverse clinical presentation and prognosis of Neisseria meningitidis infections are the result of complex host ...
Antonio Salas   +5 more
doaj   +8 more sources

Ethical aspects of genetic predisposition to environmentally-related disease

open access: hybridScience of The Total Environment, 1996
Some individuals are highly susceptible to disease caused by chemical exposures and this hypersusceptibility can be genetically determined. Because biomarker technology for the determination of genetic predisposition is at the disposal of researchers, the capability therefore exists to include genetic screening in epidemiologic studies. The application
Philippe Grandjean, Marja Sorsa
openalex   +4 more sources

Recent Advances in Diagnostic and Surveillance Strategies for Childhood Cancer Predisposition Syndromes

open access: yesClinical Pediatric Hematology-Oncology, 2023
Cancer predisposition syndromes (CPS) are a group of genetic disorders that increase the risk of developing various types of cancer. The prevalence of CPS in children has been known to be up to 18-20% based on recent reports.
Jae Won Yoo
doaj   +1 more source

OBESITY AND DYSLIPIDEMIA IN CHILDREN WITH CHRONIC HEPATITIS [PDF]

open access: yesRomanian Journal of Pediatrics, 2016
Chronic hepatitis association with various types of dyslipidemia is a reality not only for the obese pediatric patient, in which we expect to find hypercholesterolemia and / or hypertriglyceridemias, but also for normal weight children with hepatitis ...
Alice N. Azoicai   +7 more
doaj   +1 more source

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