Results 1 to 10 of about 2,694,657 (248)

Comparison Between Early-Onset and Common Gout: A Systematic Literature Review

Rheumatology and Therapy, 2023
Introduction Gout is an inflammatory, metabolic disease associated with a high comorbidity burden including cardiovascular disease, hypertension, type 2 diabetes, hyperlipidemia, renal disease, and metabolic syndrome.
Anthony J. Amatucci, Lissa Padnick-Silver, Brian LaMoreaux, David H. Bulbin   +3 more
doaj   +1 more source

Genetics of breast tumors: achievements and perspectives [PDF]

, 2014
This study was aimed to assess the genetic determinants of the breast tumors. There was shown that genetic predisposition to breast cancer is caused by multiple genes, allelic variants which lead to the low risk of the disease, but with a high frequency ...
Romak, R. P.
core  

Investigating the association of rs2910164 with cancer predisposition in an Irish cohort. [PDF]

, 2017
IntroductionMicroRNAs (miRNAs) are small noncoding RNA molecules that exert post-transcriptional effects on gene expression by binding with cis-regulatory regions in target messenger RNA (mRNA).
Bell, M, Guerin, C, Kerin, MJ, Lowery, AJ, McVeigh, TP, McVeigh, UM, Miller, N, Mulligan, RJ, Owens, PW, Quill, DS, Sebag, F, Weidhaas, JB   +11 more
core   +3 more sources

Role of Genetic Testing in Kidney Stone Disease: A Narrative Review [PDF]

Purpose of Review: Kidney stone disease (KSD) is a common and potentially life-threatening condition, and half of patients experience a repeat kidney stone episode within 5–10 years. Despite the ~50% estimate heritability of KSD, international guidelines
Geraghty, Robert, Howles, Sarah, Lovegrove, Catherine, Sayer, John A.   +3 more
core   +5 more sources

Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition [PDF]

, 2016
Perforin, a pore-forming toxin released from secretory granules of NK cells and CTLs, is essential for their cytotoxic activity against infected or cancerous target cells.
Chaudhry, MS, Gilmour, KC, House, IG, Layton, M, Panoskaltsis, N, Sohal, M, Trapani, JA, Voskoboinik, I   +7 more
core   +1 more source

Genetics of Coronary Artery Disease and Its Association with Dyslipidemia in Diabetes Mellitus in India [PDF]

, 2017
Coronary artery disease is amongst the commonest diseases seen in India. Increasingly it has been realized that Indians are very prone to get this disease.
Sethi, Chiranjeev Singh, Siwach, Ishaan, Yadav, Amit Kumar   +2 more
core   +1 more source

Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

BMC Cancer, 2011
Background Colorectal cancer (CRC) is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles ...
Moreno Victor, Villanueva Cristina M, Carvajal-Carmona Luis, Llor Xavier, Xicola Rosa M, Jover Rodrigo, Payá Artemio, Riestra Sabino, Peña Elena, Fernández-Bañares Fernando, Rigau Joaquim, Latorre Mercedes, Morillas Juan D, Cubiella Joaquin, González Dolors, Clofent Joan, Bessa Xavier, Gonzalo Victoria, Muñoz Jenifer, Alonso-Espinaco Virginia, Fernández-Rozadilla Ceres, Abulí Anna, Piqué Josep M, Carracedo Angel, Castells Antoni, Andreu Montserrat, Ruiz-Ponte Clara, Castellví-Bel Sergi   +27 more
doaj   +1 more source

Privacy-Preserving Genetic Relatedness Test [PDF]

arXiv, 2016
An increasing number of individuals are turning to Direct-To-Consumer (DTC) genetic testing to learn about their predisposition to diseases, traits, and/or ancestry. DTC companies like 23andme and Ancestry.com have started to offer popular and affordable ancestry and genealogy tests, with services allowing users to find unknown relatives and long ...
arxiv  

Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD

Hepatology Communications, 2022
Genetic predisposition and unhealthy lifestyle are risk factors for nonalcoholic fatty liver disease (NAFLD). We investigated whether the genetic risk of NAFLD is modified by physical activity, muscular fitness, and/or adiposity.
Theresia M. Schnurr, Sophia Figueroa Katz, Johanne M. Justesen, Jack W. O’Sullivan, Peter Saliba‐Gustafsson, Themistocles L. Assimes, Ivan Carcamo‐Orive, Aijaz Ahmed, Euan A. Ashley, Torben Hansen, Joshua W. Knowles   +10 more
doaj   +1 more source

Association study of functional genetic variants of innate immunity related genes in celiac disease [PDF]

, 2005
BACKGROUND: Recent evidence suggest that the innate immune system is implicated in the early events of celiac disease (CD) pathogenesis. In this work for the first time we have assessed the relevance of different proinflammatory mediators typically ...
A Craggs, A Ide, A Zhernakova, AD Eaton, AE Timms, AH Hajeer, AS Louka, AS Louka, B Rueda, B Rueda, BH Rovin, BPC Koeleman, CG Parks, CH Liao, CL Mann, D Schuppan, D Seegers, DH McDermott, EG de la Concha, EL Kaijzel, EM Nilsen, F al Sharif, F Dudbridge, FS di Giovine, G Forsberg, H Lettesjo, H Liu, HL Kim, J Martín, JA Gracie, JK Tarlow, K Nakajima, L Maiuri, L Tuckova, LM Sollid, M Tone, M Tucci, MA López-Nevot, MC Fornari, N Woolley, P Novota, PH Green, R Gade-Andavolu, RF Makki, SK Hall, SS Witkin, TL McDowell, V Giedraitis, VM Salvati, WJ Gauderman, WP Arend, Y Chowers   +51 more
core   +3 more sources