Results 1 to 10 of about 333,431 (226)

Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities [PDF]

Alzheimer’s Research & Therapy, 2019
Background Alzheimer’s disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance.
Alireza Nazarian, Anatoliy I. Yashin, Alexander M. Kulminski   +2 more
doaj   +3 more sources

Association among genetic predisposition, gut microbiota, and host immune response in the etiopathogenesis of inflammatory bowel disease [PDF]

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2014
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic disorder that affects thousands of people around the world.
Paulo José Basso, Monique T. Fonseca, Giuliano Bonfá, Vanessa Beatriz Freitas Alves, Helioswilton Sales‐Campos, Viviani Nardini, Cristina Ribeiro de Barros Cardoso   +6 more
openalex   +2 more sources

Chronic pain, depression and cardiovascular disease linked through a shared genetic predisposition: Analysis of a family-based cohort and twin study

PLoS ONE, 2017
Background Depression and chronic pain are the two most important causes of disability (Global Burden of Disease Study 2013). They occur together more frequently than expected and both conditions have been shown to be co-morbid with cardiovascular ...
Oliver van Hecke, Lynne J. Hocking, Nicola Torrance, Archie Campbell, Sandosh Padmanabhan, David J. Porteous, Andrew M. McIntosh, Andrea Burri, Haruka Tanaka, Frances M. K. Williams, Blair H. Smith   +10 more
openalex   +2 more sources

Genetic Predisposition to SARS-CoV-2 Infection: Cytokine Polymorphism and Disease Transmission within Households [PDF]

Biology, 2023
We addressed the question of the influence of the molecular polymorphism of cytokines from different T helper subsets on the susceptibility to SARS-CoV-2 infection. From a cohort of 527 samples (collected from 26 May 2020 to 31 March 2022), we focused on
Marius Saal, Henry Loeffler-Wirth, Thomas Gruenewald, Ilias Doxiadis, Claudia Lehmann   +4 more
doaj   +2 more sources

Genetic Predisposition in NAFLD and NASH: Impact on Severity of Liver Disease and Response to Treatment

Current pharmaceutical design, 2013
Liver fat deposition related to systemic insulin resistance defines non-alcoholic fatty liver disease (NAFLD) which, when associated with oxidative hepatocellular damage, inflammation, and activation of fibrogenesis, i.e.
Paola Dongiovanni, Quentin M. Anstee, Luca Valenti   +2 more
openalex   +3 more sources

The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities [PDF]

Nature Communications
Type 2 diabetes is associated with a range of non-cardiovascular non-oncologic comorbidities. To move beyond associations and evaluate causal effects between type 2 diabetes genetic predisposition and 21 comorbidities, we apply Mendelian randomization ...
Ana Luiza Arruda, Ozvan Bocher, Henry J. Taylor, Davis Cammann, Satoshi Yoshiji, Xianyong Yin, Chi Zhao, Jingchun Chen, Alexis C. Wood, Ken Suzuki, Josep M. Mercader, Cassandra N. Spracklen, James B. Meigs, Marijana Vujkovic, George Davey Smith, Jerome I. Rotter, Benjamin F. Voight, Andrew P. Morris, Eleftheria Zeggini   +18 more
doaj   +2 more sources

Genetic predisposition to Behcet's disease mediated by a IL10RA enhancer polymorphism

Heliyon
Background: Several studies suggested the genetic association between IL10RA variants and susceptibility to Behcet's disease (BD). However, the precise mechanism of the association is still unknown.
Handan Tan, Zhenyu Zhong, Xiaojie Feng, Xiang Luo, Qingfeng Cao, Peizeng Yang   +5 more
doaj   +2 more sources

Genetic Predisposition to Higher Blood Pressure Increases Coronary Artery Disease Risk [PDF]

HYPERTENSION, 2013
Wolfgang Lieb, Henning Jansen, Christina Loley, Michael J. Pencina, Christopher P. Nelson, Christopher Newton‐Cheh, Sekar Kathiresan, Muredach P. Reilly, Themistocles L. Assimes, Eric Boerwinkle, Alistair S. Hall, Christian Hengstenberg, Reijo Laaksonen, Ruth McPherson, Unnur Þorsteinsdóttir, Andreas Ziegler, Annette Peters, John R. Thompson, Inke R. König, Jeanette Erdmann, Nilesh J. Samani, Ramachandran S. Vasan, Heribert Schunkert   +22 more
openalex   +2 more sources

Recent Advances in Diagnostic and Surveillance Strategies for Childhood Cancer Predisposition Syndromes

Clinical Pediatric Hematology-Oncology, 2023
Cancer predisposition syndromes (CPS) are a group of genetic disorders that increase the risk of developing various types of cancer. The prevalence of CPS in children has been known to be up to 18-20% based on recent reports.
Jae Won Yoo
doaj   +1 more source

OBESITY AND DYSLIPIDEMIA IN CHILDREN WITH CHRONIC HEPATITIS [PDF]

Romanian Journal of Pediatrics, 2016
Chronic hepatitis association with various types of dyslipidemia is a reality not only for the obese pediatric patient, in which we expect to find hypercholesterolemia and / or hypertriglyceridemias, but also for normal weight children with hepatitis ...
Alice N. Azoicai, Bogdan A. Stana, Paula Popovici, Ileana K. Ioniuc, Monica M. Alexoae, Irina Criscov, Alina M. Murgu, Evelina Moraru   +7 more
doaj   +1 more source