Results 1 to 10 of about 320,413 (381)
Genetic Predisposition to Infectious Disease [PDF]
Cureus, 2018 In contemporary medical practice, approaches to infectious disease management have been primarily rooted in a pathogen-centered model. However, host genetics also contribute significantly to infectious disease burden. The fast expansion of bioinformatics
N. Klebanov
semanticscholar +4 more sources
Genetic Predisposition to Cardiovascular Diseases [PDF]
International Journal of Human Genetics, 2001 Extensive clinical and statistical studies have identified several factors that increase the risk of heart disease, heart attack and stroke. Major risk factors are those that are associated with a significant increase in the risk of heart and blood vessel disease (CVD).
Dharam P. Agarwal
openalex +3 more sources
PLoS ONE, 2009 Background and aimsMeningococcal disease remains one of the most important infectious causes of death in industrialized countries. The highly diverse clinical presentation and prognosis of Neisseria meningitidis infections are the result of complex host ...
Antonio Salas +5 more
doaj +8 more sources
Genetic predisposition in nonalcoholic fatty liver disease [PDF]
Clinical and Molecular Hepatology, 2017 Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic ...
S. Sookoian, C. Pirola
semanticscholar +5 more sources
Sexual Differences in Genetic Predisposition of Coronary Artery Disease. [PDF]
Circulation: Genomic and Precision Medicine, 2020 Background - The genomic structure that contributes to the risk of coronary artery disease (CAD) can be evaluated as a risk score of multiple variants.
Yunfeng Huang +6 more
semanticscholar +4 more sources
PLoS Medicine, 2014 In this study, Proitsi and colleagues use a Mendelian randomization approach to dissect the causal nature of the association between circulating lipid levels and late onset Alzheimer's Disease (LOAD) and find that genetic predisposition to increased ...
Petroula Proitsi +16 more
openalex +3 more sources
Genetic predisposition to smoking in relation to 14 cardiovascular diseases
European Heart Journal, 2020 Aims The aim of this study was to use Mendelian randomization (MR) to determine the causality of the association between smoking and 14 different cardiovascular diseases (CVDs).
S. Larsson +6 more
semanticscholar +5 more sources
Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer’s disease [PDF]
Translational Psychiatry, 2021 AbstractAlzheimer’s disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of Alzheimer associated neuropathological changes, and Alzheimer’s disease occurrence within 14 years ...
Hannah Stocker +10 more
openalex +6 more sources
Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities
Alzheimer’s Research & Therapy, 2019 Background Alzheimer’s disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance.
Alireza Nazarian +2 more
doaj +2 more sources
Simple and complex ABCR: genetic predisposition to retinal disease. [PDF]
The American Journal of Human Genetics, 2000 Diseases of the retina include a wide spectrum of photoreceptor-affecting phenotypes that have been mapped to >120 loci on the human genome (RetNet Retinal Information Network).
R. Allikmets
semanticscholar +4 more sources