Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs. [PDF]
, 2020 BackgroundHistiocytic sarcoma affecting the central nervous system (CNS HS) in dogs may present as primary or disseminated disease, often characterized by inflammation.
Crowe, Chelsea M +10 more
core
Genetics and Epigenetics of Arrhythmia and Heart Failure
Frontiers in Genetics, 2013 Heart failure (HF) is the end stage of several pathological cardiac conditions including myocardial infarction, cardiac hypertrophy and hypertension. Various molecular and cellular mechanisms are involved in the development of HF. At the molecular level,
Burcu eDuygu +2 more
doaj +1 more source
Dysregulation of Antiviral Helicase Pathways in Systemic Lupus Erythematosus
Frontiers in Genetics, 2014 In the autoimmune disease systemic lupus erythematosus (SLE), our normal antiviral defenses are inappropriately activated, resulting in over-activity of the type I interferon pathway.
Luciana eOliveira +4 more
doaj +1 more source
Routes for breaching and protecting genetic privacy [PDF]
arXiv, 2013 We are entering the era of ubiquitous genetic information for research, clinical care, and personal curiosity. Sharing these datasets is vital for rapid progress in understanding the genetic basis of human diseases. However, one growing concern is the ability to protect the genetic privacy of the data originators.
arxiv
Increasing the Discovery Power and Confidence Levels of Disease Association Studies: A Survey [PDF]
arXiv, 2017 The majority of common diseases are influenced by multiple genetic and environmental factors such as Cancer. Even though uncovering the main causes of disease is deemed difficult due to the complexity of gene-gene and gene-environment interactions, major research efforts aim at identifying disease risk factors, especially genetic ones.
arxiv
Patient Attitudes Toward Genetic Testing for Inherited Predispositions to Hematologic Malignancies [PDF]
, 2018 Although inherited predispositions to hematologic malignancies have previously been considered extremely rare, approximately 12 causative genes have been implicated in the last decade.
Beecroft, Taylor
core +1 more source
MedicinaBackground and Objectives: The aim of the following cross-sectional study is to determine the association between human leukocyte antigen (HLA) alleles and outcomes in patients presenting to the emergency department (ED) with SARS-CoV-2 infection ...
Ester Lobato-Martinez +8 more
doaj +1 more source
Exploring the genetic patterns of complex diseases via the integrative genome-wide approach [PDF]
arXiv, 2015 Motivation: Genome-wide association studies (GWASs), which assay more than a million single nucleotide polymorphisms (SNPs) in thousands of individuals, have been widely used to identify genetic risk variants for complex diseases. However, most of the variants that have been identified contribute relatively small increments of risk and only explain a ...
arxiv
Genetically selected baby free of inherited predisposition to early-onset Alzheimer's disease [PDF]
, 2002 Merle Spriggs
openalex +1 more source
Genome-wide Causation Studies of Complex Diseases [PDF]
arXiv, 2019 Despite significant progress in dissecting the genetic architecture of complex diseases by genome-wide association studies (GWAS), the signals identified by association analysis may not have specific pathological relevance to diseases so that a large fraction of disease causing genetic variants is still hidden. Association is used to measure dependence
arxiv