Results 1 to 10 of about 203,716 (120)
Genetic Predisposition to Thrombophilia in Inflammatory Bowel Disease [PDF]
Journal of Clinical Gastroenterology, 2011 Inflammatory bowel disease (IBD) is linked to a definite risk of thromboembolic events (TE), but data on the role of prothrombotic genetic mutations are conflicting.Fourteen genetic factors involved in TE pathogenesis were investigated in a homogeneous cohort of Sicilian patients with IBD with and without history of TE and in healthy controls.
Cappello, M +7 more
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Genetic Predisposition to Infectious Disease [PDF]
Cureus, 2018 In contemporary medical practice, approaches to infectious disease management have been primarily rooted in a pathogen-centered model. However, host genetics also contribute significantly to infectious disease burden. The fast expansion of bioinformatics techniques and the popularization of the genome-wide association study (GWAS) in recent decades ...
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Genetic predisposition of cholesterol gallstone disease
Annals of Hepatology, 2006 Gallstone disease (GSD) is the result of the interaction between genetic and environmental factors and it is a major disease cause of surgery with high costs to health systems. Worldwide prevalence varies according to the ethnic population suggesting that high prevalence of GSD in certain ethnic groups is due to the presence of genetic factors ...
Alejandro Hernández-Nazará +4 more
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Genetic predisposition and the variable course of infectious diseases
Deutsches Ärzteblatt international, 2022 Contact with a pathogen is followed by variable courses of infectious disease, which are only partly explicable by classical risk factors. The susceptibility to infection is variable, as is the course of disease after infection. In this review, we discuss the extent to which this variation is due to genetic factors of the affected individual (the host).
Axel, Schmidt +4 more
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Venous Thromboembolism in Kidney Diseases and Genetic Predisposition
Kidney Diseases, 2022 <b><i>Background:</i></b> Many renal diseases have been associated with profound clinical effects on thrombosis. To our knowledge, patients with nephrotic syndrome (NS) and chronic kidney disease (CKD) display an elevated risk of vein thrombosis, which is among the common causes of mortality in patients with renal diseases.
Tingting Wu, Liang V. Tang, Yu Hu
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Genetic Predisposition and Inflammatory Bowel Disease [PDF]
Gastroenterology Research, 2013 Published reports demonstrated finding of different susceptible mutant alleles in association with inflammatory bowel disease (CD/UC) in diseased individuals from different populations. It was then assumed that the existence of different associated mutant alleles in subjects with inflammatory bowel disease from different populations means different ...
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Genetic Predisposition to Respiratory Diseases: Infiltrative Lung Diseases [PDF]
Respiration, 2006 The availability of high-throughput genotyping and large collaborative clinical networks creating well-characterized patient populations with DNA repositories has facilitated genome-wide scans and candidate gene studies to identify susceptibility alleles for the development of interstitial lung disease.
Mark P, Steele, Kevin K, Brown
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Genetic predisposition in nonalcoholic fatty liver disease [PDF]
Clinical and Molecular Hepatology, 2017 Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening
Sookoian, Silvia Cristina +1 more
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Genetic Predisposition to Cardiovascular Diseases [PDF]
International Journal of Human Genetics, 2001 Extensive clinical and statistical studies have identified several factors that increase the risk of heart disease, heart attack and stroke. Major risk factors are those that are associated with a significant increase in the risk of heart and blood vessel disease (CVD).
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Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands
Pharmacogenetics and Genomics, 2008 To investigate whether the genetic variants of CYP2D6 and HFE are more frequent in Parkinson's disease (PD) patients compared with controls in a population where the prevalence of these variants and PD are increased.Blood samples were collected from 79 PD patients and 154 controls in the Faroe Islands.
Halling, Jónrit +4 more
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