Beyond Barker: Infant Mortality at Birth and Ischaemic Heart Disease in Older Age [PDF]
, 2022 Adverse conditions in early life can have consequential impacts on individuals' health in older age. In one of the first papers on this topic, Barker and Osmond 1986 show a strong positive relationship between infant mortality rates in the 1920s and ischaemic heart disease in the 1970s.
arxiv +1 more source
Genetic Predisposition to Coronary Artery Disease: Evaluating Statin Therapy in Elder Populations From PROSPER. [PDF]
JACC AdvChoi SH +7 more
europepmc +2 more sources
Venous Thromboembolism in Kidney Diseases and Genetic Predisposition
Kidney Diseases, 2022 <b><i>Background:</i></b> Many renal diseases have been associated with profound clinical effects on thrombosis. To our knowledge, patients with nephrotic syndrome (NS) and chronic kidney disease (CKD) display an elevated risk of vein thrombosis, which is among the common causes of mortality in patients with renal diseases.
Tingting Wu, Liang V. Tang, Yu Hu
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Two-sample mendelian randomization analysis of associations between periodontal disease and risk of cancer. [PDF]
, 2021 Background: Observational studies indicate that periodontal disease may increase the risk of colorectal, lung, and pancreatic cancers. Using a 2-sample Mendelian randomization (MR) analysis, we assessed whether a genetic predisposition index for ...
Amos, CI +14 more
core +1 more source
Sexual Differences in Genetic Predisposition of Coronary Artery Disease [PDF]
Circulation: Genomic and Precision Medicine, 2021 Background: The genomic structure that contributes to the risk of coronary artery disease (CAD) can be evaluated as a risk score of multiple variants. However, sex differences have not been fully examined in applications of genetic risk score (GRS) of CAD.
Yunfeng Huang +6 more
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Genetic Predisposition to Infectious Disease [PDF]
Cureus, 2018 In contemporary medical practice, approaches to infectious disease management have been primarily rooted in a pathogen-centered model. However, host genetics also contribute significantly to infectious disease burden. The fast expansion of bioinformatics techniques and the popularization of the genome-wide association study (GWAS) in recent decades ...
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BMC Medicine, 2023 Background The predictive relationship between mild-to-moderate alcohol consumption and the risk of incident atrial fibrillation (AF) remains controversial.
Chan Soon Park +9 more
doaj +1 more source
Genetic Predisposition to Respiratory Diseases: Infiltrative Lung Diseases [PDF]
Respiration, 2006 The availability of high-throughput genotyping and large collaborative clinical networks creating well-characterized patient populations with DNA repositories has facilitated genome-wide scans and candidate gene studies to identify susceptibility alleles for the development of interstitial lung disease.
Mark P. Steele, Kevin K. Brown
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Association between arterial hypertension and liver outcomes using polygenic risk scores : a population-based study [PDF]
, 2022 Arterial hypertension (HTA) is associated with liver disease, but causality remains unclear. We investigated whether genetic predisposition to HTA is associated with liver disease in the population, and if antihypertensive medication modifies this ...
But, Anna +11 more
core +1 more source
Genetic predisposition and the variable course of infectious diseases
Deutsches Ärzteblatt international, 2022 Contact with a pathogen is followed by variable courses of infectious disease, which are only partly explicable by classical risk factors. The susceptibility to infection is variable, as is the course of disease after infection. In this review, we discuss the extent to which this variation is due to genetic factors of the affected individual (the host).
Axel, Schmidt +4 more
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