Results 61 to 70 of about 191,359 (264)

A tagging polymorphism in fat mass and obesity-associated (FTO) gene is associated with sepsis status in children

Romanian Journal of Internal Medicine
Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition.
Jabandziev Petr, Hubacek Jaroslav Alois, Michalek Jaroslav, Jouza Martin, Papez Jan, Pecl Jakub, Slaba Katerina, Slaby Ondrej, Urik Milan, Aulicka Stefania, Kunovsky Lumir, Michalek Jaroslav, Dominik Petr, Kratochvil Milan, Klucka Jozef, Stourac Petr   +15 more
doaj   +1 more source

Association Between IL-4 and IL-6 Expression Variants and Gastric Cancer Among Portuguese Population

GE: Portuguese Journal of Gastroenterology, 2015
Introduction: Multiple studies have reported strong associations between Helicobacter pylori (Hp) inflammation and gastric cancer (GC) development. Altered expressions of pro/anti-inflammatory cytokines have a crucial role in Hp and GC proliferation ...
Ana Maria Sampaio, Sandra Caramujo Balseiro, Maria Reis Silva, Ana Alarcão, Maria João d’Aguiar, Teresa Ferreira, Lina Carvalho   +6 more
doaj   +1 more source

Association between genetic predisposition and disease burden of stroke in China: a genetic epidemiological study. [PDF]

Lancet Reg Health West Pac, 2023
Huang Q, Lan X, Chen H, Li H, Sun Y, Ren C, Xing C, Bo X, Wang J, Jin X, Song L.   +10 more
europepmc   +1 more source

Simple and Complex ABCR: Genetic Predisposition to Retinal Disease [PDF]

The American Journal of Human Genetics, 2000
Diseases of the retina include a wide spectrum of photoreceptor-affecting phenotypes that have been mapped to >120 loci on the human genome (RetNet Retinal Information Network). Currently, less than half of the causal genes have been identified (RetNet Retinal Information Network), although substantial progress has been made in determining the genetic ...
openaire   +2 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci

World Allergy Organization Journal
Background: Allergic rhinitis (AR) is a common chronic respiratory disease that can lead to the development of various other conditions. Although genetic risk loci associated with AR have been reported, the connections between these loci and AR ...
Xingling Tan, MD, Zhouyouyou Xiao, MB, Yao Wen, MD, Han Liu, MD, Wei Yu, MD   +4 more
doaj   +1 more source

Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

BMC Cancer, 2011
Background Colorectal cancer (CRC) is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles ...
Moreno Victor, Villanueva Cristina M, Carvajal-Carmona Luis, Llor Xavier, Xicola Rosa M, Jover Rodrigo, Payá Artemio, Riestra Sabino, Peña Elena, Fernández-Bañares Fernando, Rigau Joaquim, Latorre Mercedes, Morillas Juan D, Cubiella Joaquin, González Dolors, Clofent Joan, Bessa Xavier, Gonzalo Victoria, Muñoz Jenifer, Alonso-Espinaco Virginia, Fernández-Rozadilla Ceres, Abulí Anna, Piqué Josep M, Carracedo Angel, Castells Antoni, Andreu Montserrat, Ruiz-Ponte Clara, Castellví-Bel Sergi   +27 more
doaj   +1 more source

Nano‐Engineered Titanium Implants Loaded With Gingival Fibroblasts‐Derived Microvesicles Enhance Early Osseointegration And Soft Tissue Attachment In Vivo

Advanced Healthcare Materials, EarlyView.
Our study showed that human primary gingival fibroblast–derived microvesicles on nano‐engineered titanium implants promote early osseointegration and soft‐tissue attachment in vivo. ABSTRACT Titanium dental implants require both reliable osseointegration and peri‐implant soft tissue seal formation to ensure long‐term success. While osseointegration has
Pingping Han, Chun Liu, Anjana Jayasree, Kamil Sokolowski, Andrew Liaw, Dingbin Liu, Carlos Salomon, Karan Gulati, Ryan SB Lee, Baoxin Huang, Sašo Ivanovski   +10 more
wiley   +1 more source

Living with Risk, Aging with Uncertainty: A Narrative Review of Health and Genetic Vulnerability in Huntington’s Disease

Biomedicines
Background/Objectives: Huntington’s disease (HD) is an autosomal dominant, neurodegenerative disorder that, because of the availability of presymptomatic genetic testing, places at-risk individuals in an anticipatory situation of great emotional, ethical,
Adriana V. Muñoz-Ortega, David Conde Caballero, Lorenzo Mariano Juárez   +2 more
doaj   +1 more source