Results 61 to 70 of about 187,732 (244)

A tagging polymorphism in fat mass and obesity-associated (FTO) gene is associated with sepsis status in children

Romanian Journal of Internal Medicine
Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition.
Jabandziev Petr, Hubacek Jaroslav Alois, Michalek Jaroslav, Jouza Martin, Papez Jan, Pecl Jakub, Slaba Katerina, Slaby Ondrej, Urik Milan, Aulicka Stefania, Kunovsky Lumir, Michalek Jaroslav, Dominik Petr, Kratochvil Milan, Klucka Jozef, Stourac Petr   +15 more
doaj   +1 more source

Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci

World Allergy Organization Journal
Background: Allergic rhinitis (AR) is a common chronic respiratory disease that can lead to the development of various other conditions. Although genetic risk loci associated with AR have been reported, the connections between these loci and AR ...
Xingling Tan, MD, Zhouyouyou Xiao, MB, Yao Wen, MD, Han Liu, MD, Wei Yu, MD   +4 more
doaj   +1 more source

Ethical aspects of genetic predisposition to environmentally-related disease

Science of The Total Environment, 1996
Some individuals are highly susceptible to disease caused by chemical exposures and this hypersusceptibility can be genetically determined. Because biomarker technology for the determination of genetic predisposition is at the disposal of researchers, the capability therefore exists to include genetic screening in epidemiologic studies. The application
P, Grandjean, M, Sorsa
openaire   +2 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

BMC Cancer, 2011
Background Colorectal cancer (CRC) is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles ...
Moreno Victor, Villanueva Cristina M, Carvajal-Carmona Luis, Llor Xavier, Xicola Rosa M, Jover Rodrigo, Payá Artemio, Riestra Sabino, Peña Elena, Fernández-Bañares Fernando, Rigau Joaquim, Latorre Mercedes, Morillas Juan D, Cubiella Joaquin, González Dolors, Clofent Joan, Bessa Xavier, Gonzalo Victoria, Muñoz Jenifer, Alonso-Espinaco Virginia, Fernández-Rozadilla Ceres, Abulí Anna, Piqué Josep M, Carracedo Angel, Castells Antoni, Andreu Montserrat, Ruiz-Ponte Clara, Castellví-Bel Sergi   +27 more
doaj   +1 more source

Association between genetic predisposition and disease burden of stroke in China: a genetic epidemiological study. [PDF]

Lancet Reg Health West Pac, 2023
Huang Q, Lan X, Chen H, Li H, Sun Y, Ren C, Xing C, Bo X, Wang J, Jin X, Song L.   +10 more
europepmc   +1 more source

Simple and Complex ABCR: Genetic Predisposition to Retinal Disease [PDF]

The American Journal of Human Genetics, 2000
Diseases of the retina include a wide spectrum of photoreceptor-affecting phenotypes that have been mapped to >120 loci on the human genome (RetNet Retinal Information Network). Currently, less than half of the causal genes have been identified (RetNet Retinal Information Network), although substantial progress has been made in determining the genetic ...
openaire   +2 more sources

Cell Calcification Models and Their Implications for Medicine and Biomaterial Research

Advanced Healthcare Materials, EarlyView.
Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen‐Dechent, Sergio Bertazzo   +5 more
wiley   +1 more source

A Human‐Based Skin‐Lymphoreticular Model‐on‐Chip to Emulate Inflammatory Skin Conditions

Advanced Healthcare Materials, EarlyView.
A human‐based lymphoreticular (LR) model was developed through guided self‐assembly and integrated in a skin‐lymphoreticular co‐culture in a microfluidic organ‐on‐chip to mimic interactions between skin and its draining lymph nodes. The human‐based skin‐lymphoreticular model resembles a minimally functional unit that allows to study interactions ...
Zheng Tan, Partho Protim Adhikary, Dana Wörz, Sarah Hedtrich   +3 more
wiley   +1 more source

Living with Risk, Aging with Uncertainty: A Narrative Review of Health and Genetic Vulnerability in Huntington’s Disease

Biomedicines
Background/Objectives: Huntington’s disease (HD) is an autosomal dominant, neurodegenerative disorder that, because of the availability of presymptomatic genetic testing, places at-risk individuals in an anticipatory situation of great emotional, ethical,
Adriana V. Muñoz-Ortega, David Conde Caballero, Lorenzo Mariano Juárez   +2 more
doaj   +1 more source