Results 131 to 140 of about 972,925 (267)

Harnessing genetic resistance to rusts in wheat and integrated rust management methods to develop more durable resistant cultivars. [PDF]

Front Plant Sci, 2022
Mapuranga J, Zhang N, Zhang L, Liu W, Chang J, Yang W.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The Paraphyletic Origins of Genetic Resistance to Cabbage Stem Flea Beetle in <i>Brassica oleracea</i>. [PDF]

Plant Environ Interact
Tiret M, Falentin C, Lariagon C, Blandin C, Boudet M, Rollandez D, Lauverney A, Bazerque Q, Manzanares-Dauleux M, Robert C, Faure S, Gravot A.   +11 more
europepmc   +1 more source

Advancement in the Breeding, Biotechnological and Genomic Tools towards Development of Durable Genetic Resistance against the Rice Blast Disease. [PDF]

Plants (Basel), 2022
Sahu PK, Sao R, Choudhary DK, Thada A, Kumar V, Mondal S, Das BK, Jankuloski L, Sharma D.   +8 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Coinfection affects the phenotypic but not genetic resistance of cattle to common parasites. [PDF]

Genet Sel Evol
Toral FLB, Souza MV, de Moraes MM, Riggio V, Gouveia GC, Ribeiro VMP, Anacleto O, Cardoso EP, Gonçalves DR, Doeschl-Wilson A.   +9 more
europepmc   +1 more source

Prediction of Genetic Resistance for Scrapie in Ungenotyped Sheep Using a Linear Animal Model. [PDF]

Genes (Basel), 2021
Boareki M, Schenkel F, Kennedy D, Cánovas A.   +3 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Sheep Genetic Resistance to Gastrointestinal Nematode Infections: Current Insights from Transcriptomics and Other OMICs Technologies-A Review. [PDF]

Pathogens
Sinhalage K, Polizel GHG, Karrow NA, Schenkel FS, Cánovas Á.   +4 more
europepmc   +1 more source

Potential Targets for CRISPR/Cas Knockdowns to Enhance Genetic Resistance Against Some Diseases in Wheat (Triticum aestivum L.). [PDF]

Front Genet, 2022
Taj M, Sajjad M, Li M, Yasmeen A, Mubarik MS, Kaniganti S, He C.   +6 more
europepmc   +1 more source