Results 151 to 160 of about 972,925 (267)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Role of Genetic Resistance in Rice Disease Management. [PDF]

Int J Mol Sci
Danso Ofori A, Zheng T, Titriku JK, Appiah C, Xiang X, Kandhro AG, Ahmed MI, Zheng A.   +7 more
europepmc   +1 more source

Insights Into Natural Genetic Resistance to Rice Yellow Mottle Virus and Implications on Breeding for Durable Resistance. [PDF]

Front Plant Sci, 2021
Odongo PJ, Onaga G, Ricardo O, Natsuaki KT, Alicai T, Geuten K.   +5 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Genetic resistance to vector-borne hemoprotozoa in livestock: molecular markers, host-parasite interactions, and implications for breeding and control. [PDF]

J Vet Sci
Salim B, Alasmari S, Bakheit MA.
europepmc   +1 more source

Evolution of Multidrug Resistance in Plasmodium falciparum: a Longitudinal Study of Genetic Resistance Markers in the Greater Mekong Subregion. [PDF]

Antimicrob Agents Chemother, 2021
Imwong M, Suwannasin K, Srisutham S, Vongpromek R, Promnarate C, Saejeng A, Phyo AP, Proux S, Pongvongsa T, Chea N, Miotto O, Tripura R, Nguyen Hoang C, Dysoley L, Ho Dang Trung N, Peto TJ, Callery JJ, van der Pluijm RW, Amaratunga C, Mukaka M, von Seidlein L, Mayxay M, Thuy-Nhien NT, Newton PN, Day NPJ, Ashley EA, Nosten FH, Smithuis FM, Dhorda M, White NJ, Dondorp AM.   +30 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Status on Genetic Resistance to Rice Blast Disease in the Post-Genomic Era. [PDF]

Plants (Basel)
Pedrozo R, Osakina A, Huang Y, Nicolli CP, Wang L, Jia Y.   +5 more
europepmc   +1 more source

MicroRNA-mediated host defense mechanisms against pathogens and herbivores in rice: balancing gains from genetic resistance with trade-offs to productivity potential. [PDF]

BMC Plant Biol, 2022
Kumar K, Mandal SN, Neelam K, de Los Reyes BG.   +3 more
europepmc   +1 more source