Results 171 to 180 of about 972,925 (267)

The Paratuberculosis Paradigm Examined: A Review of Host Genetic Resistance and Innate Immune Fitness in Mycobacterium avium subsp. Paratuberculosis Infection. [PDF]

Front Vet Sci, 2021
Kravitz A, Pelzer K, Sriranganathan N.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Genome-wide characterization of structure variations in the Xiang pig for genetic resistance to African swine fever. [PDF]

Virulence
Qi F, Chen X, Wang J, Niu X, Li S, Huang S, Ran X.   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

First Report of Genetic Resistance to Azithromycin in <i>Treponema pallidum</i> from Blood Samples Among Men Who Have Sex with Men and People Living with HIV from Mexico. [PDF]

Microorganisms
Vergara-Ortega DN, Santibañez-Amador PJ, García-Cisneros S, Olamendi-Portugal M, Gutiérrez-Millán E, Herrera-Ortíz A, Ruíz-González V, Sánchez-Alemán MÁ.   +7 more
europepmc   +1 more source

Principles and mechanisms of non-genetic resistance in cancer. [PDF]

Br J Cancer, 2020
Bell CC, Gilan O.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

<i>Solanum pimpinellifolium</i> exhibits complex genetic resistance to <i>Pseudomonas syringae</i> pv. <i>tomato</i>. [PDF]

Front Plant Sci
Hassan JA, Diplock N, Chau-Ly IJ, Calma J, Boville E, Yee S, Harris TM, Lewis JD.   +7 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Mitigating non-genetic resistance to checkpoint inhibition based on multiple states of immune exhaustion. [PDF]

NPJ Syst Biol Appl
Kareva I, Gevertz JL.
europepmc   +1 more source