Results 211 to 220 of about 7,418,451 (334)

Prediction of Genetic Resistance for Scrapie in Ungenotyped Sheep Using a Linear Animal Model. [PDF]

Genes (Basel), 2021
Boareki M, Schenkel F, Kennedy D, Cánovas A.   +3 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Coinfection affects the phenotypic but not genetic resistance of cattle to common parasites. [PDF]

Genet Sel Evol
Toral FLB, Souza MV, de Moraes MM, Riggio V, Gouveia GC, Ribeiro VMP, Anacleto O, Cardoso EP, Gonçalves DR, Doeschl-Wilson A.   +9 more
europepmc   +1 more source

COVID-19, varying genetic resistance to viral disease and immune tolerance checkpoints. [PDF]

Immunol Cell Biol, 2021
Goodnow CC.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Sheep Genetic Resistance to Gastrointestinal Nematode Infections: Current Insights from Transcriptomics and Other OMICs Technologies-A Review. [PDF]

Pathogens
Sinhalage K, Polizel GHG, Karrow NA, Schenkel FS, Cánovas Á.   +4 more
europepmc   +1 more source

In silico QTL mapping in an oil palm breeding program reveals a quantitative and complex genetic resistance to Ganoderma boninense. [PDF]

Mol Breed, 2021
Daval A, Pomiès V, le Squin S, Denis M, Riou V, Breton F, Nopariansyah, Bink M, Cochard B, Jacob F, Billotte N, Tisné S.   +11 more
europepmc   +1 more source

Bacterial Genetics and Drug Resistance [PDF]

Public Health Reports (1896-1970), 1952
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Immune cell-resolved transcriptomics provides insights into the basis for variations of fish genetic resistance to viral disease. [PDF]

BMC Biol
Clark TC, Thomas V, Taylor RS, Charles M, Laurent A, Schwartz-Cornil I, Collet B, Lallias D, Macqueen DJ, Martin SAM, Boudinot P.   +10 more
europepmc   +1 more source