Results 91 to 100 of about 681,929 (290)
Genetic ResourcesThis paper introduces EURISCO-EVA, an extension of the European Search Catalogue for Plant Genetic Resources (EURISCO) hosted at and maintained by IPK Gatersleben on behalf of the European Cooperative Programme for Plant Genetic Resources (ECPGR).
Suman Kumar +3 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Genetic ResourcesPlant genetic resources are essential for sustainable agriculture and a secure and stable global food supply. One of the most important pulses and an integral part of a healthy diet is lentil (Lens culinaris Medik.).
Nadiia Vus +7 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The role of traditional knowledge and access to genetic resources in biodiversity conservation in Southeast Asia [PDF]
, 2010 Christoph Antons
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Genetic ResourcesA morphological and genetic characterization of autochthonous ‘Saragolla’ wheats, currently cultivated in Abruzzo Region (Italy), was carried out.
Agata Rascio +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Genetic ResourcesFrom 2002 to 2022, the Agricultural Plant Genetic Resources Conservation and Research Centre (APGRC) in Sudan conducted 56 collecting missions for plant genetic resources for food and agriculture (PGRFA) in Sudan.
Ibrahim Mohamed El Tahir +5 more
doaj +1 more source