Results 81 to 90 of about 5,465,577 (394)

Native Plasmid-Encoded Mercury Resistance Genes Are Functional and Demonstrate Natural Transformation in Environmental Bacterial Isolates. [PDF]

open access: yes, 2019
Plasmid-mediated horizontal gene transfer (HGT) is a major driver of genetic diversity in bacteria. We experimentally validated the function of a putative mercury resistance operon present on an abundant 8-kbp native plasmid found in groundwater samples ...
Carlson, Hans K   +5 more
core   +1 more source

Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells [PDF]

open access: yes, 2015
The final published version can be found here: http://dx.doi.org/10.1073/pnas ...
Anna Karlsson   +18 more
core   +1 more source

Genetic resources and genetic transformation in bermudagrass – a review

open access: yes, 2018
Bermudagrass is widely distributed as a warm-season turf and forage grass in the temperate and tropical zones around the world. Its strong vegetative reproduction and ability to withstand drought make it an ideal species as a most used warm-season forage
Shilian Huang, Chen Wang, Jun-song Liang
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae

open access: yesNature Communications, 2017
Competence for genetic transformation is a differentiation program during which exogenous DNA is imported into the cell and integrated into the chromosome. In Streptococcus pneumoniae, competence develops transiently and synchronously in all cells during
M. Bergé   +7 more
semanticscholar   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

open access: yesFEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa   +8 more
wiley   +1 more source

Potato R1 resistance gene confers resistance against Phytophthora infestans in transgenic tomato plants [PDF]

open access: yes, 2010
Tomato is challenged by several pathogens which cause loss of production. One such pathogen is the oomycete Phytophthora infestans which is able to attack all the aerial parts of the plant.
Carli, P.   +5 more
core   +3 more sources

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Advances in genetic manipulation of obligate intracellular bacterial pathogens

open access: yesFrontiers in Cellular and Infection Microbiology, 2011
Infections by obligate intracellular bacterial pathogens result in significant morbidity and mortality worldwide. These bacteria include Chlamydia spp., which causes millions of cases of sexually transmitted disease and blinding trachoma annually, and ...
Paul eBeare   +4 more
doaj   +1 more source

Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta [PDF]

open access: yes, 2010
IgA and IgE activity against Teladorsagia circumcincta was investigated in a flock of Texel lambs following natural, mixed nematode infection among lambs.
Bishop, S.C.   +6 more
core   +1 more source

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