Results 121 to 130 of about 1,230,887 (337)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Human Metapneumovirus Genetic Variability, South Africa

Emerging Infectious Diseases, 2005
The molecular epidemiology and genetic diversity of the human metapneumovirus (hMPV) were characterized for a 3-year period (2000–2002) from viruses that were identified in South Africa.
Herbert P. Ludewick, Yacine Abed, Nadia van Niekerk, Guy Boivin, Keith P. Klugman, Shabir A. Madhi   +5 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Study of genetic variability and correlation in interspecific derivatives of Pigeonpea [Cajanus cajan (L.) Millsp.] [PDF]

Electronic Journal of Plant Breeding, 2010
Forty interspecific derivatives (ISD) of Pigeonpea along with five national checks derived from ICRISAT, Patancheru,Hyderabad and one local check were screened to study the extent of genetic variability for yield and yield contributingcharacter and their
S.S. Linge , H.V. Kalpande, S.L. Sawargaonkar, B.V. Hudge and H.P. Thanki
doaj  

Genetic analysis and qtl mapping of agro-morphological traits in lowland rice (Oryza sativa L.) under drought conditions [PDF]

, 2016
The present study was undertaken to evaluate lowland rice genetic variability associated with agro-morphological traits under drought condition. A set of 250 recombinant inbred lines (RILs) from the cross between rice parental cultivarIR64 (sensitive to ...
Audebert, Alain, Hema, Drissa, Kam, Honore, Konate, Abdourasmane K., Sangaré, Jean Rodrigue, Sanni, Ambaliou, Zongo, Adama   +6 more
core  

Natural selection. II. Developmental variability and evolutionary rate

, 2011
In classical evolutionary theory, genetic variation provides the source of heritable phenotypic variation on which natural selection acts. Against this classical view, several theories have emphasized that developmental variability and learning enhance ...
Altschuler, Ancel, Anderson, Aubret, Avery, Baldwin, Bell, Booth, Chevin, Chevin, Coyne, Crispo, De Jong, Frank, Frank, Frank, Gavrilets, Gavrilets, Gavrilets, Geyer, Haldane, Hall, Hinton, Holland, Kaneko, Kirkpatrick, Kirschner, Lande, Lande, Loh, Mayley, Maynard Smith, Mayr, Mills, Murphy, Niepel, Pigliucci, Pigliucci, Pigliucci, Price, Rainey, Rajon, Rice, Rubin, Schlichting, Spencer, Sumner, Suzuki, Turney, Turney, Waddington, Waddington, Wagner, West-Eberhard, Whitlock, Woods, Wright, Yomo   +57 more
core   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Genetic variability, correlation and path analysis inAshwagandha [Withania somnifera (L.) Dunal] [PDF]

Electronic Journal of Plant Breeding, 2014
Forty diverse genotypes of Ashwagandha [Withania somnifera (L.)Dunal] were evaluated for 12 quantitative characters. Higher magnitude of genotypic and phenotypic coefficient of variation was recorded for leaf width, number of primary branches per plant ...
Nilesh R. Joshi, M. A. Patel, K.N. Prajapati and A. D. Patel
doaj  

Genetic variability in commencement of flowering in Medicago lupulina L. in the South Island of New Zealand [PDF]

, 1968
J. Lammerink
openalex   +1 more source