Results 201 to 210 of about 2,029,300 (329)

Genetic Variation Related to High Elevation Adaptation Revealed by Common Garden Experiments in Pinus yunnanensis

, 2020
Yan‐Qiang Sun, Wei Zhao, Chaoqun Xu, Yulan Xu, Yousry A. El‐Kassaby, Amanda R. De La Torre, Jian‐Feng Mao   +6 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Investigating the interplay between prematurity and genetic variation in the context of rare developmental disorders. [PDF]

Genome Med
Wootton O, Campbell P, Richardson S, Lindsay SJ, Huang QQ, Delage E, Amanat S, Wong HS, Firth HV, Hurles ME, Simpson MA, Radford EJ, Martin HC.   +12 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Genetic variation influences food-sharing sociability in honey bees. [PDF]

PLoS Biol
Traniello IM, Avalos A, Gachomba MJM, Gernat T, Chen Z, Cash-Ahmed AC, Hamilton AR, Cook JL, Robinson GE.   +8 more
europepmc   +1 more source

Identification of novel genetic variations affecting osteoarthritis patients [PDF]

, 2016
Mamdooh Gari, Mohammed Alkaff, Haneen Alsehli, Ashraf Dallol, Abdullah Gari, Muhammad Abu‐Elmagd, Roaa Kadam, Mohammed F. Abuzinadah, Mazin Gari, Adel Abuzenadah, Kalamegam Gauthaman, Heba Alkhatabi, Mohammed Abbas   +12 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Genetic variation associated with side effects of hormonal contraception exposure: a narrative review. [PDF]

Front Reprod Health
Nuzzo M, Erickson EN, Groth SW, Yu Y, Koleck T, Li H, Martinez K, Zaman A, Dreisbach C.   +8 more
europepmc   +1 more source

Analysis of spatial genetic variation reveals genetic divergence among populations of Primula veris associated to contrasting habitats [PDF]

, 2017
Pablo Deschepper, Rein Brys, Miguel A. Fortuna, Hans Jacquemyn   +3 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source