Results 1 to 10 of about 5,232,810 (279)
Targeted therapy in age-related macular degeneration (AMD)
Journal of Education, Health and Sport, 2020 Introduction and purpose: Age-related macular degeneration (AMD) is a major cause of blindness in highly developed countries, with blindness frequency of 8.7%.
Klaudia Daria Szumna +4 more
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DNA Vaccine Construct Formation using Mycobacterium-Specific Gene Inh-A
Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2022 BACKGROUND: Tuberculosis (TB) remains a highly contagious disease and a leading cause of death worldwide. It is caused by Mycobacterium tuberculosis and Mycobacterium bovis. TB infection is still uncontrolled because of the unavailability of an effective
Summayya Anwar +4 more
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AAV vectors: The Rubik’s cube of human gene therapy
Molecular Therapy, 2022 Defective genes account for ∼80% of the total of more than 7,000 diseases known to date. Gene therapy brings the promise of a one-time treatment option that will fix the errors in patient genetic coding.
A. Pupo +5 more
semanticscholar +1 more source
Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector–Host Interactions
Viruses, 2021 Adenovirus-based vectors are playing an important role as efficacious genetic vaccines to fight the current COVID-19 pandemic. Furthermore, they have an enormous potential as oncolytic vectors for virotherapy and as vectors for classic gene therapy ...
Denice Weklak +5 more
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An optimized retroviral toolbox for overexpression and genetic perturbation of primary lymphocytes
Biology Open, 2022 Genetic manipulation of primary lymphocytes is crucial for both clinical purposes and fundamental research. Despite their broad use, we encountered a paucity of data on systematic comparison and optimization of retroviral vectors, the workhorses of ...
Lieve E. H. van der Donk +7 more
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Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
Parasites & Vectors, 2022 This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control ...
N. Ratcliffe +6 more
semanticscholar +1 more source
Novel vectors and approaches for gene therapy in liver diseases
JHEP Reports, 2021 Summary Gene therapy is becoming an increasingly valuable tool to treat many genetic diseases with no or limited treatment options. This is the case for hundreds of monogenic metabolic disorders of hepatic origin, for which liver transplantation remains ...
Sheila Maestro +4 more
semanticscholar +1 more source
Pharmaceutics, 2022 Cancer is the leading cause of death worldwide. Tumors consist of heterogeneous cell populations that have different biological properties. While conventional cancer therapy such as chemotherapy, radiotherapy, and surgery does not target cancer cells ...
Ioana Toma +4 more
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Immune Responses to Viral Gene Therapy Vectors
Molecular Therapy, 2020 Several viral vector-based gene therapy drugs have now received marketing approval. A much larger number of additional viral vectors are in various stages of clinical trials for the treatment of genetic and acquired diseases, with many more in pre ...
Jamie L. Shirley +3 more
semanticscholar +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 The piRNA pathway is a specialized small RNA interference that in mosquitoes is mechanistically distant from analogous biology in the Drosophila model.
Vanessa M. Macias +5 more
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