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Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases [PDF]
Viruses, 2021 Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used ...
Valentina Poletti, Fulvio Mavilio
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Biomimetic Peptides: A New Generation of Gene Transfer Vectors [PDF]
مجله دانشکده پزشکی اصفهان, 2022 Gene therapy is a new approach that aims to modify defective genes or intracellular expression of therapeutic proteins, and this depends on the use of high-efficiency gene transfer systems.
Hooman Mahmoudi Aznaveh, Maryam Nikkhah
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Differentiation of Human Adipose-Derived Mesenchymal Stromal/Stem Cells into Insulin-Producing Cells with A Single Tet-Off Lentiviral Vector System [PDF]
Cell Journal, 2022 Objective: Human adipose-derived mesenchymal stromal/stem cells (hASC) constitute an attractive source of stemcells for cell-based therapies in regenerative medicine and tissue engineering as they are easy to acquire fromlipoaspirate, expansion, and ...
Hiroyuki Moriyama +4 more
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Genetic control of vectors [PDF]
Pests and vector-borne diseases in the livestock industry, 2018 In a context of tighter regulations on approved insecticide molecules, the spread of insecticide resistance in insect vectors of human and animal diseases and the introduction of exotic vectors to new territories call for the development of new pest control methods and strategies.
Bouyer, Jérémy, Marois, Eric
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Biomedicines, 2023 The biosafety of gene therapy remains a crucial issue for both the direct and cell-mediated delivery of recombinant cDNA encoding biologically active molecules for the pathogenetic correction of congenital or acquired disorders.
Ilnur I. Salafutdinov +10 more
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Biomedicines, 2023 Background: Pathological changes associated with spinal cord injury (SCI) can be observed distant, rostral, or caudal to the epicenter of injury. These remote areas represent important therapeutic targets for post-traumatic spinal cord repair.
Ravil Garifulin +9 more
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CD20 and CD19 targeted vectors induce minimal activation of resting B lymphocytes [PDF]
, 2013 B lymphocytes are an important cell population of the immune system. However, until recently it was not possible to transduce resting B lymphocytes with retro- or lentiviral vectors, making them unsusceptible for genetic manipulations by these vectors ...
A Pezzutto +51 more
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Integrase deficient lentiviral vector: prospects for safe clinical applications [PDF]
PeerJ, 2022 HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells among many viral vectors. Genetic material transduced by lentiviral vector is integrated into the cell genome to introduce new ...
Chee-Hong Takahiro Yew +6 more
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Genetics of Mosquito Vector Competence [PDF]
Microbiology and Molecular Biology Reviews, 2000 SUMMARY Mosquito-borne diseases are responsible for significant human morbidity and mortality throughout the world. Efforts to control mosquito-borne diseases have been impeded, in part, by the development of drug-resistant parasites, insecticide-resistant mosquitoes, and environmental concerns over the application of ...
B T, Beerntsen +2 more
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Targeted therapy in age-related macular degeneration (AMD)
Journal of Education, Health and Sport, 2020 Introduction and purpose: Age-related macular degeneration (AMD) is a major cause of blindness in highly developed countries, with blindness frequency of 8.7%.
Klaudia Daria Szumna +4 more
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