Genetics of Major Insect Vectors
, 2011 Publisher Summary Vector-borne diseases are responsible for a substantial portion of the global disease. Control of insect vectors is often the best and sometimes the only way to protect the population from these destructive diseases. This chapter reviews vector genetics of three of the most important vector-borne diseases that have much to contribute
Dorn, P.L. +4 more
openaire +3 more sources
Genetic modification of baculovirus expression vectors
Virologica Sinica, 2012 As a protein expression vector, the baculovirus demonstrates many advantages over other vectors. With the development of biotechnology, baculoviral vectors have been genetically modified to facilitate high level expression of heterologous proteins in both insect and mammalian cells.
Shufen Li +3 more
openaire +3 more sources
Optimising DNA binding to carbon nanotubes by non-covalent methods [PDF]
, 2011 The use of carbon nanotubes as a gene delivery system has been extensively studied in recent years owing to its potential advantages over viral vectors.
Anna Marie Galibert +29 more
core +2 more sources
Genetic engineering of baker’s and wine yeasts using formaldehyde hyperresistance-mediating plasmids [PDF]
, 2009 Yeast multi-copy vectors carrying the for maldehyde-resistance marker gene SFA have proved to be a valuable tool for research on industrially used strains of Saccharomyces cerevisiae.
Brendel, Martin (Prof. Dr.) +3 more
core
Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk [PDF]
, 2012 We have previously shown that injury-induced neointima formation was rescued by adenoviral-Nogo-B gene delivery. Integrase-competent lentiviral vectors (ICLV) are efficient at gene delivery to vascular cells but present a risk of insertional mutagenesis.
Adrian J. Thrasher +11 more
core +1 more source
Malaria Control with Genetically Manipulated Insect Vectors
Science, 2002 At a recent workshop, experts discussed the benefits, risks, and research priorities associated with using genetically manipulated insects in the control of vector-borne diseases.
Alphey L. +22 more
openaire +5 more sources
Orientation of the genetic variance-covariance matrix and the fitness surface for multiple male sexually selected traits [PDF]
, 2004 Stabilizing selection has been predicted to change genetic variances and covariances so that the orientation of the genetic variance-covariance matrix (G) becomes aligned with the orientation of the fitness surface, but it is less clear how directional ...
Blows, Mark W. +2 more
core +1 more source
Assessment of Genetic Shielding for Adenovirus Vectors [PDF]
The Open Gene Therapy Journal, 2009 Development of adenovirus (Ad) vectors in the clinical context has highlighted that vector efficacy may be limited by the host humoral response due to pre-existing titers of neutralizing antibodies against the vector itself in humans. Further, multiple dosing of Ad vectors based on serotype 5 would be limited.
Hui-Chen Hsu +7 more
openaire +2 more sources
Genetic tools for Sulfolobus spp.: vectors and first applications [PDF]
, 2018 Sulfolobus species belong to the best-studied archaeal organisms but have lacked powerful genetic methods. Recently, there has been considerable progress in the field of Sulfolobus genetics.
Berkner, Silvia, Lipps, Georg
core
De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications. [PDF]
, 2015 Mammalian artificial chromosomes (MACs) are non-integrating, autonomously replicating natural chromosome-based vectors that may carry a vast amount of genetic material, which in turn enable potentially prolonged, safe, and regulated therapeutic transgene
Katona, Róbert László
core +1 more source