Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases
Viruses, 2021 Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used ...
Valentina Poletti, Fulvio Mavilio
doaj +2 more sources
Emerging cancer vaccines: the promise of genetic vectors. [PDF]
Cancers (Basel), 2011 Therapeutic vaccination against cancer is an important approach which, when combined with other therapies, can improve long-term control of cancer. In fact, the induction of adaptive immune responses against Tumor Associated Antigens (TAAs) as well as ...
Aurisicchio L, Ciliberto G.
europepmc +2 more sources
Genetic Variation in Insect Vectors: Death of Typology?
Insects, 2018 The issue of typological versus population thinking in biology is briefly introduced and defined. It is then emphasized how population thinking is most relevant and useful in vector biology.
Jeffrey R. Powell
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Developing Universal Genetic Tools for Rapid and Efficient Deletion Mutation in Vibrio Species Based on Suicide T-Vectors Carrying a Novel Counterselectable Marker, vmi480. [PDF]
PLoS ONE, 2015 Despite that Vibrio spp. have a significant impact on the health of humans and aquatic animals, the molecular basis of their pathogenesis is little known, mainly due to the limited genetic tools for the functional research of genes in Vibrio.
Peng Luo +3 more
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The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications
Viruses, 2014 A long time has passed since the first clinical trial with adenoviral (Ad) vectors. Despite being very promising, Ad vectors soon revealed their limitations in human clinical trials.
Cristian Capasso +3 more
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Biomimetic Peptides: A New Generation of Gene Transfer Vectors [PDF]
مجله دانشکده پزشکی اصفهان, 2022 Gene therapy is a new approach that aims to modify defective genes or intracellular expression of therapeutic proteins, and this depends on the use of high-efficiency gene transfer systems.
Hooman Mahmoudi Aznaveh, Maryam Nikkhah
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Differentiation of Human Adipose-Derived Mesenchymal Stromal/Stem Cells into Insulin-Producing Cells with A Single Tet-Off Lentiviral Vector System [PDF]
Cell Journal, 2022 Objective: Human adipose-derived mesenchymal stromal/stem cells (hASC) constitute an attractive source of stemcells for cell-based therapies in regenerative medicine and tissue engineering as they are easy to acquire fromlipoaspirate, expansion, and ...
Hiroyuki Moriyama +4 more
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Biomedicines, 2023 The biosafety of gene therapy remains a crucial issue for both the direct and cell-mediated delivery of recombinant cDNA encoding biologically active molecules for the pathogenetic correction of congenital or acquired disorders.
Ilnur I. Salafutdinov +10 more
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Integrase deficient lentiviral vector: prospects for safe clinical applications [PDF]
PeerJ, 2022 HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells among many viral vectors. Genetic material transduced by lentiviral vector is integrated into the cell genome to introduce new ...
Chee-Hong Takahiro Yew +6 more
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Biomedicines, 2023 Background: Pathological changes associated with spinal cord injury (SCI) can be observed distant, rostral, or caudal to the epicenter of injury. These remote areas represent important therapeutic targets for post-traumatic spinal cord repair.
Ravil Garifulin +9 more
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