Results 21 to 30 of about 123,260 (289)
A genetic-algorithm-based method to find the unitary transformations for any de- sired quantum computation and application to a one-bit oracle decision problem [PDF]
J. Korean Phys. Soc. 65, 2001, 2014 We propose a genetic-algorithm-based method to find the unitary transformations for any desired quantum computation. We formulate a simple genetic algorithm by introducing the "genetic parameter vector" of the unitary transformations to be found. In the genetic algorithm process, all components of the genetic parameter vectors are supposed to evolve to
arxiv +1 more source
Human Vaccines & Immunotherapeutics, 2017 Background: Genetic immunization is expected to induce the expression of antigens in a native form. The encoded peptide epitopes are presented on endogenous MHC molecules, mimicking antigen presentation during a viral infection.
S. Stenler +12 more
doaj +1 more source
Antigen capsid-display on human adenovirus 35 via pIX fusion is a potent vaccine platform. [PDF]
PLoS ONE, 2017 Durable protection against complex pathogens is likely to require immunity that comprises both humoral and cellular responses. While heterologous prime-boost regimens based on recombinant, replication-incompetent Adenoviral vectors (AdV) and adjuvanted ...
Nadine C Salisch +10 more
doaj +1 more source
Emerging Cancer Vaccines: The Promise of Genetic Vectors [PDF]
Cancers, 2011 Therapeutic vaccination against cancer is an important approach which, when combined with other therapies, can improve long-term control of cancer. In fact, the induction of adaptive immune responses against Tumor Associated Antigens (TAAs) as well as innate immunity are important factors for tumor stabilization/eradication.
Gennaro Ciliberto, Luigi Aurisicchio
openaire +2 more sources
Comparison of REML methods for the study of phenome-wide genetic variation [PDF]
arXiv, 2022 It is now well documented that genetic covariance between functionally related traits leads to an uneven distribution of genetic variation across multivariate trait combinations, and possibly a large part of phenotype-space that is inaccessible to evolution.
arxiv
RNA Viral Vectors for Accelerating Plant Synthetic Biology
Frontiers in Plant Science, 2021 The tools of synthetic biology have enormous potential to help us uncover the fundamental mechanisms controlling development and metabolism in plants.
Arjun Khakhar +3 more
doaj +1 more source
Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro. [PDF]
PLoS ONE, 2012 In central nervous system (CNS)-directed gene therapy, efficient targeting of brain parenchyma through the vascular route is prevented by the endothelium and the epithelium of the blood-brain and the blood-cerebrospinal fluid barriers, respectively.
Johanna P Laakkonen +6 more
doaj +1 more source
Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases
Viruses, 2021 Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used ...
Valentina Poletti, Fulvio Mavilio
doaj +1 more source
BiomedicinesBackground: The biosafety of gene therapy products remains a major challenge to their introduction into the clinic. In particular, the problem of immunogenicity of viral vectors is the focus of attention.
Andrei Izmailov +11 more
doaj +1 more source
Colony polymerase chain reaction of stably transfected Trypanosoma cruzi grown on solid medium [PDF]
Memorias do Instituto Oswaldo Cruz, 2000 Tools for the genetic manipulation of Trypanosoma cruzi are largely unavailable, although several vectors for transfection of epimastigotes and expression of foreign or recombinant genes have been developed. We have previously constructed several plasmid
Wagner G dos Santos +2 more
doaj +1 more source