Results 21 to 30 of about 617,752 (328)
Visualizing genetic constraints [PDF]
, 2013 Principal Components Analysis (PCA) is a common way to study the sources of variation in a high-dimensional data set. Typically, the leading principal components are used to understand the variation in the data or to reduce the dimension of the data for ...
Gaydos, Travis L. +6 more
core +3 more sources
Frontiers in Cellular and Infection Microbiology, 2021 The piRNA pathway is a specialized small RNA interference that in mosquitoes is mechanistically distant from analogous biology in the Drosophila model.
Vanessa M. Macias +5 more
doaj +1 more source
Genetic elimination of dengue vector mosquitoes [PDF]
Proceedings of the National Academy of Sciences, 2011 An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression. A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti , was
Hong-Fei Gong +6 more
openaire +3 more sources
In vivo genetic manipulation of inner ear connexin expression by bovine adeno-Associated viral vectors [PDF]
, 2017 We have previously shown that in vitro transduction with bovine adeno-associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin-deficient mice that are models DFNB1 ...
Campioni, Matteo +7 more
core +1 more source
Sparse reduced-rank regression for imaging genetics studies: models and applications [PDF]
, 2012 We present a novel statistical technique; the sparse reduced rank regression (sRRR) model which is a strategy for multivariate modelling of high-dimensional imaging responses and genetic predictors.
Vounou, Maria, Vounou, Maria
core +1 more source
Human Vaccines & Immunotherapeutics, 2017 Background: Genetic immunization is expected to induce the expression of antigens in a native form. The encoded peptide epitopes are presented on endogenous MHC molecules, mimicking antigen presentation during a viral infection.
S. Stenler +12 more
doaj +1 more source
Rescue of splicing-mediated intron loss maximizes expression in lentiviral vectors containing the human ubiquitin C promoter. [PDF]
, 2014 Lentiviral vectors almost universally use heterologous internal promoters to express transgenes. One of the most commonly used promoter fragments is a 1.2-kb sequence from the human ubiquitin C (UBC) gene, encompassing the promoter, some enhancers, first
Cooper, Aaron R +3 more
core +1 more source
Insight into the Machinery and Applications for Understanding the Pathogen- Vector Interface [PDF]
, 2012 The availability of genome sequencing data in combination with knowledge of expressed genes via transcriptome and proteome data has greatly advanced our understanding of arthropod vectors of disease.
Barnard, Annette-Christi +4 more
core +1 more source
Antigen capsid-display on human adenovirus 35 via pIX fusion is a potent vaccine platform. [PDF]
PLoS ONE, 2017 Durable protection against complex pathogens is likely to require immunity that comprises both humoral and cellular responses. While heterologous prime-boost regimens based on recombinant, replication-incompetent Adenoviral vectors (AdV) and adjuvanted ...
Nadine C Salisch +10 more
doaj +1 more source
Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases
Viruses, 2021 Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used ...
Valentina Poletti, Fulvio Mavilio
doaj +1 more source