Results 21 to 30 of about 4,784,986 (369)

Molecular Genetic Manipulation of Vector Mosquitoes [PDF]

Cell Host & Microbe, 2008
Genetic strategies for reducing populations of vector mosquitoes or replacing them with those that are not able to transmit pathogens benefit greatly from molecular tools that allow gene manipulation and transgenesis. Mosquito genome sequences and associated EST (expressed sequence tags) databases enable large-scale investigations to provide new ...
Terenius, Olle, Marinotti, Osvaldo, Sieglaff, Douglas, James, Anthony A.   +3 more
openaire   +2 more sources

Prospects for transgenesis in the chick [PDF]

, 2004
Research to develop a useful method for genetic modification of the chick has been on-going since the first demonstrations in the mouse in the 1980s that genetic modification is an invaluable tool for the study of gene function. Manipulation of the chick
Bosselman, Brazolot, Carsience, Challita, D'Costa, Evans, Eyal-Giladi, Hamburger, Han, Harvey, Harvey, Hofmann, Ikawa, Isvak, Itasaki, Ivarie, Kagami, Lois, Love, Mizuarai, Mozdziak, Mozdziak, Naito, Naito, Naito, Naldini, Nieuwkoop, Niwa, Pain, Perry, Petitte, Petitte, Pfeifer, Rapp, Reynaud, Rubinson, Salter, Salter, Sang, Sherman, Speksnijder, Stern, Tajima, Thomson, Thoraval, Tiscornia, Tsunekawa, Urven, Vick, Vick, Waddington, Wentworth, Zajchowski   +52 more
core   +1 more source

Morphological identification and genetic characterization of Anopheles stephensi in Somaliland

Parasites & Vectors, 2022
Malaria control in Somaliland depends on the effective identification of potential malaria vectors, particularly those that may be invasive. The malaria vector Anopheles stephensi has been detected in multiple countries in the Horn of Africa (HOA), but ...
Said Ali, J. N. Samake, Joseph D. Spear, Tamar E. Carter   +3 more
semanticscholar   +1 more source

A Quality by Design Approach in Pharmaceutical Development of Non-Viral Vectors with a Focus on miRNA

Pharmaceutics, 2022
Cancer is the leading cause of death worldwide. Tumors consist of heterogeneous cell populations that have different biological properties. While conventional cancer therapy such as chemotherapy, radiotherapy, and surgery does not target cancer cells ...
Ioana Toma, Alina Silvia Porfire, Lucia Ruxandra Tefas, Ioana Berindan-Neagoe, Ioan Tomuță   +4 more
doaj   +1 more source

Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries [PDF]

, 2011
Malaria and dengue are the most prevalent mosquito-borne infections worldwide. Because traditional vector control methods have proven to be insufficient to control mosquito populations in endemic areas, scientists are actively working in the design of ...
Gostin, Lawrence O., Ostera, Graciela R.
core   +2 more sources

Leaning Into the Bite: The piRNA Pathway as an Exemplar for the Genetic Engineering Need in Mosquitoes

Frontiers in Cellular and Infection Microbiology, 2021
The piRNA pathway is a specialized small RNA interference that in mosquitoes is mechanistically distant from analogous biology in the Drosophila model.
Vanessa M. Macias, Umberto Palatini, Mariangela Bonizzoni, Jason L. Rasgon, Jason L. Rasgon, Jason L. Rasgon   +5 more
doaj   +1 more source

Visualizing genetic constraints [PDF]

, 2013
Principal Components Analysis (PCA) is a common way to study the sources of variation in a high-dimensional data set. Typically, the leading principal components are used to understand the variation in the data or to reduce the dimension of the data for ...
Gaydos, Travis L., Heckman, Nancy E., Kingsolver, Joel, Kirkpatrick, Mark, Marron, J. S., Schmitt, Johanna, Stinchcombe, J. R.   +6 more
core   +3 more sources

Genetic elimination of dengue vector mosquitoes [PDF]

Proceedings of the National Academy of Sciences, 2011
An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression. A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti , was
Megan R, Wise de Valdez, Derric, Nimmo, John, Betz, Hong-Fei, Gong, Anthony A, James, Luke, Alphey, William C, Black   +6 more
openaire   +2 more sources

The genetic architecture of target‐site resistance to pyrethroid insecticides in the African malaria vectors Anopheles gambiae and Anopheles coluzzii

bioRxiv, 2018
Resistance to pyrethroid insecticides is a major concern for malaria vector control, because these are the compounds used in almost all insecticide-treated bed-nets (ITNs), and are also widely used for indoor residual spraying (IRS).
Chris S. Clarkson, A. Miles, N. Harding, A. O’Reilly, D. Weetman, D. Kwiatkowski, M. Donnelly   +6 more
semanticscholar   +1 more source

In vivo genetic manipulation of inner ear connexin expression by bovine adeno-Associated viral vectors [PDF]

, 2017
We have previously shown that in vitro transduction with bovine adeno-associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin-deficient mice that are models DFNB1 ...
Campioni, Matteo, Chiorini, John A., Crispino, Giulia, Di Pasquale, Giovanni, Galindo Ramirez, Fabian, Mammano, Fabio, Praetorius, Mark, Zorzi, Veronica   +7 more
core   +1 more source