Results 61 to 70 of about 634,337 (325)

Developing Universal Genetic Tools for Rapid and Efficient Deletion Mutation in Vibrio Species Based on Suicide T-Vectors Carrying a Novel Counterselectable Marker, vmi480. [PDF]

PLoS ONE, 2015
Despite that Vibrio spp. have a significant impact on the health of humans and aquatic animals, the molecular basis of their pathogenesis is little known, mainly due to the limited genetic tools for the functional research of genes in Vibrio.
Peng Luo, Xiangyan He, Qiuting Liu, Chaoqun Hu   +3 more
doaj   +1 more source

Applications and developments of gene therapy drug delivery systems for genetic diseases

Asian Journal of Pharmaceutical Sciences, 2021
Genetic diseases seriously threaten human health and have always been one of the refractory conditions facing humanity. Currently, gene therapy drugs such as siRNA, shRNA, antisense oligonucleotide, CRISPR/Cas9 system, plasmid DNA and miRNA have shown ...
Xiuhua Pan, Hanitrarimalala Veroniaina, Nan Su, Kang Sha, Fenglin Jiang, Zhenghong Wu, Xiaole Qi   +6 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Joint and individual analysis of breast cancer histologic images and genomic covariates [PDF]

, 2020
A key challenge in modern data analysis is understanding connections between complex and differing modalities of data. For example, two of the main approaches to the study of breast cancer are histopathology (analyzing visual characteristics of tumors ...
Calhoun, Benjamin C., Carmichael, Iain, Couture, Heather D., Geradts, Joseph, Hannig, Jan, Hoadley, Katherine A., Marron, J. S., Niethammer, Marc, Olsson, Linnea, Perou, Charles M., Troester, Melissa A.   +10 more
core   +3 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Intracranial hemorrhage detection in 3D computed tomography images using a bi-directional long short-term memory network-based modified genetic algorithm

Frontiers in Neuroscience, 2023
IntroductionIntracranial hemorrhage detection in 3D Computed Tomography (CT) brain images has gained more attention in the research community. The major issue to deal with the 3D CT brain images is scarce and hard to obtain the labelled data with better ...
Jewel Sengupta, Robertas Alzbutas, Przemysław Falkowski-Gilski, Bożena Falkowska-Gilska   +3 more
doaj   +1 more source

Hybridization in parasites: consequences for adaptive evolution, pathogenesis and public health in a changing world [PDF]

, 2015
[No abstract ...
A Berry, A Koukounari, AJ Norton, AR Laird, B Schelkle, BL Webster, BL Webster, BL Webster, BR Grant, C Astrom, C Gyles, CA Machado, CD Criscione, CM Brasier, CM Lively, CM Lively, CS Clarkson, CS Wondji, D Menge, D Rollinson, D Weetman, DB Dunams-Morel, DE Neafsey, Deborah F. Smith, DR Brooks, DR Dittrich-Reed, E Inbar, E Mancini, E Redman, E Strauch, EH Stukenbrock, EJ Baack, GL Nichols, Glenn F Rall, H Krehenwinkel, H Ochman, H Ochman, HD Mawejje, HJ Müller, HV Pates, I Goodhead, J Boissier, J Davies, J Hawks, J Mallet, J Mavarez, JA Coyne, JA Patz, JC Semenza, JM Kelly, Joanne P. Webster, JP Webster, JP Webster, JT Detwiler, Kayla C. King, KD Lafferty, LA Messenger, LA Messenger, LAT Tchuente, LC Norris, LH Rieseberg, LH Rieseberg, M Arnold, M Lynch, M Schumer, M Worobey, MA Miles, MA Nowak, MB Rogers, MB Rogers, MC Fontaine, ME Grigg, MF Dybdahl, MG Taylor, Michael A. Brockhurst, MJ Gibbs, ML Arnold, ML Arnold, ML Steinauer, MW Gaunt, NH Barton, NR Sturm, NS Akopyants, O Seehausen, P Martens, P Volf, P Volf, PW Hedrick, R Abbott, RA Farrer, RB Stelkens, RB Stelkens, RDH Barrett, Rike B. Stelkens, RS Ramiro, S Edmands, S Hales, S Manguin, S Moore, T Dobzhansky, T Huyse, T Huyse, TH Le, U Chaudhry, W Alves, W Choochote, W Li, Y Lee, Y Song   +108 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Population genomics of the Asian tiger mosquito, Aedes albopictus. Insights into the recent worldwide invasion [PDF]

, 2017
Aedes albopictus, the “Asian tiger mosquito,” is an aggressive biting mosquito native to Asia that has colonized all continents except Antarctica during the last ~30–40 years. The species is of great public health
Aguirre-Obando, Alexander, Armbruster, Baird, Becker, Beebe, Benedict, Birungi, Bonizzoni, Brady, Brown, Chen, Chen, Chouin-Carneiro, Dalla Pozza, Damal, Danecek, Das, Delatte, Denlinger, Eaton, Egizi, Emerson, Excoffier, Flacio, Foll, Frichot, Galtier, Gloria-Soria, Goubert, Gratz, Hawley, Hemingway, Hurst, Ismail, Jackson, Jombart, Kambhampati, Kambhampati, Kamgang, Kamgang, Kasai, Lamballerie, Lambrechts, Langmead, Lewis, Li, Lischer, Liu, Lounibos, Lounibos, Lourenco de Oliveira, Luu, Manni, Manni, Marcombe, Maynard, Medley, Medlock, Minard, Morens, Mori, Mousson, Nazareno, O'Donnell, Patterson, Paupy, Pech-May, Peterson, Porretta, Porretta, Powell, Puckett, Reiter, Smartt, Sprenger, Stamatakis, Tatem, Trucchi, Urbanelli, Urbanski, Willing, Wong, Wray, Wu, Xu, Zhong   +86 more
core   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source