Genetically modified mouse models for the study of nonalcoholic fatty liver disease. [PDF]
World J Gastroenterol, 2012 Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and type 2 diabetes. NAFLD represents a large spectrum of diseases ranging from (1) fatty liver (hepatic steatosis); (2) steatosis with inflammation and necrosis; to
Nagarajan P +4 more
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Genetically modified mouse models of cancer invasion and metastasis.
Drug Discov Today Dis Models, 2011 Tumor invasion and metastasis is a multi-step process that requires adaptation of cancer cells to conditions that they encounter during their journey to distant body sites. Understanding the molecular processes that underlie this adaptation is of exceeding importance because most cancer patients die because of metastases rather than primary tumors.
Rampetsreiter P, Casanova E, Eferl R.
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Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models. [PDF]
Drug Metab Rev, 2011 Determining the in vivo significance of a specific enzyme, transporter, or xenobiotic receptor in drug metabolism and pharmacokinetics may be hampered by gene multiplicity and complexity, levels of expression, and interaction between various components involved.
Jiang XL, Gonzalez FJ, Yu AM.
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Genetically modified mouse models addressing gonadotropin function.
Reproductive Biology, 2014 The development of genetically modified animals has been useful to understand the mechanisms involved in the regulation of the gonadotropin function. It is well known that alterations in the secretion of a single hormone is capable of producing profound reproductive abnormalities.
L. Ratner, S. Rulli, I. Huhtaniemi
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Probing the Scope and Mechanisms of Calcitriol Actions Using Genetically Modified Mouse Models [PDF]
JBMR Plus, 2021 Genetically modified mice have provided novel insights into the mechanisms of activation and inactivation of vitamin D, and in the process have provided phenocopies of acquired human disease such as rickets and osteomalacia and inherited diseases such as
Dengshun Miao, David Goltzman
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Lipidomic and metabolomic characterization of a genetically modified mouse model of the early stages of human type 1 diabetes pathogenesis. [PDF]
Metabolomics, 2016 The early mechanisms regulating progression towards beta cell failure in type 1 diabetes (T1D) are poorly understood, but it is generally acknowledged that genetic and environmental components are involved. The metabolomic phenotype is sensitive to minor
Overgaard AJ +6 more
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Manipulations with early mouse embryos for generation of genetically modified animals
Вавиловский журнал генетики и селекции, 2017 Recently, genome-editing technologies have become more efficient and accessible. The discovery of nucleases for directional genome editing (CRISPR/Cas9, TALEN, ZFNs) significantly accelerated and simplified the production of mice with targeted gene ...
A. N. Korablev +2 more
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Determination of the Potential Tumor-Suppressive Effects of Gsdme in a Chemically Induced and in a Genetically Modified Intestinal Cancer Mouse Model [PDF]
Cancers, 2019 Gasdermin E (GSDME), also known as deafness autosomal dominant 5 (DFNA5) and previously identified to be an inducer of regulated cell death, is frequently epigenetically inactivated in different cancer types, suggesting that GSDME is a tumor suppressor ...
Lieselot Croes +9 more
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Experimental Neurobiology, 2019 Genetically modified mouse models are being used predominantly to understand brain functions and diseases. Well-designed and controlled behavioral analyses of genetically modified mice have successfully led to the identification of gene functions ...
Dong-Hee Kim +3 more
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Two new genetically modified mouse alleles labeling distinct phases of retinal ganglion cell development by fluorescent proteins. [PDF]
Dev Dyn, 2020 Ge Y, Wu F, Cheng M, Bard J, Mu X.
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