Genetically modified mouse models to help fight COVID-19. [PDF]
Nat Protoc, 2020 The research community is in a race to understand the molecular mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to repurpose currently available antiviral drugs and to develop new therapies and vaccines against coronavirus disease 2019 (COVID-19).
Gurumurthy CB +5 more
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Conserving, distributing and managing genetically modified mouse lines by sperm cryopreservation. [PDF]
PLoS ONE, 2008 Sperm from C57BL/6 mice are difficult to cryopreserve and recover. Yet, the majority of genetically modified (GM) lines are maintained on this genetic background.Reported here is the development of an easily implemented method that consistently yields ...
G Charles Ostermeier +3 more
doaj +4 more sources
A novel genetically modified mouse seizure model for evaluating anticonvulsive and neuroprotective efficacy of an A<sub>1</sub> adenosine receptor agonist following soman intoxication. [PDF]
Toxicol Appl Pharmacol, 2023 Shih TM.
europepmc +3 more sources
Genetically Modified Mouse Models in Studies on Cutaneous Wound Healing [PDF]
Experimental Physiology, 2000 Genetically modified mice have become an invaluable tool in modern biomedical and basic research. This review provides an overview of knockout and transgenic mice studied with regard to their cutaneous wound healing properties. In addition, several gene transfer studies are briefly introduced, which have further highlighted our knowledge on individual ...
Annette Scheid +3 more
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Dissecting the Roles of Gonadotropin-Inhibitory Hormone in Mammals: Studies Using Pharmacological Tools and Genetically Modified Mouse Models. [PDF]
Front Endocrinol (Lausanne), 2015 Leon S, Tena-Sempere M.
europepmc +2 more sources
Genetically Modified <i>Lactococcus lactis</i> Hypersecreting IL-1Ra Improves Glucose Metabolism and Modulates the Gut Microbiota in an Obese Mouse Model. [PDF]
J Diabetes ResYoda M +9 more
europepmc +2 more sources
Genetically Modified Mouse Mesenchymal Stem Cells Expressing Non-Structural Proteins of Hepatitis C Virus Induce Effective Immune Response. [PDF]
Vaccines (Basel), 2020 Masalova OV +12 more
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Ocular surface mucins and local inflammation--studies in genetically modified mouse lines. [PDF]
BMC Ophthalmol, 2015 Shirai K, Saika S.
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Tumor-targeting Salmonella typhimurium A1-R inhibits human prostate cancer experimental bone metastasis in mouse models. [PDF]
, 2015 Bone metastasis is a frequent occurrence in prostate cancer patients and often is lethal. Zoledronic acid (ZOL) is often used for bone metastasis with limited efficacy.
Bouvet, Michael +9 more
core +17 more sources
Genetically modified mouse models to study hepatic neutral lipid mobilization. [PDF]
Biochim Biophys Acta Mol Basis Dis, 2019 Excessive accumulation of triacylglycerol is the common denominator of a wide range of clinical pathologies of liver diseases, termed non-alcoholic fatty liver disease. Such excessive triacylglycerol deposition in the liver is also referred to as hepatic steatosis.
Haemmerle G, Lass A.
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