Genetically modified mouse models to study hepatic neutral lipid mobilization. [PDF]
Biochim Biophys Acta Mol Basis Dis, 2019 Excessive accumulation of triacylglycerol is the common denominator of a wide range of clinical pathologies of liver diseases, termed non-alcoholic fatty liver disease. Such excessive triacylglycerol deposition in the liver is also referred to as hepatic steatosis.
Haemmerle G, Lass A.
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Genetically Modified Mouse Models in Studies on Cutaneous Wound Healing [PDF]
Experimental Physiology, 2000 Genetically modified mice have become an invaluable tool in modern biomedical and basic research. This review provides an overview of knockout and transgenic mice studied with regard to their cutaneous wound healing properties. In addition, several gene transfer studies are briefly introduced, which have further highlighted our knowledge on individual ...
Annette Scheid +3 more
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Lipidomic and metabolomic characterization of a genetically modified mouse model of the early stages of human type 1 diabetes pathogenesis. [PDF]
Metabolomics, 2016 The early mechanisms regulating progression towards beta cell failure in type 1 diabetes (T1D) are poorly understood, but it is generally acknowledged that genetic and environmental components are involved. The metabolomic phenotype is sensitive to minor
Overgaard AJ +6 more
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Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models. [PDF]
Drug Metab Rev, 2011 Determining the in vivo significance of a specific enzyme, transporter, or xenobiotic receptor in drug metabolism and pharmacokinetics may be hampered by gene multiplicity and complexity, levels of expression, and interaction between various components involved.
Jiang XL, Gonzalez FJ, Yu AM.
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Genetically modified mouse models of cancer invasion and metastasis.
Drug Discov Today Dis Models, 2011 Tumor invasion and metastasis is a multi-step process that requires adaptation of cancer cells to conditions that they encounter during their journey to distant body sites. Understanding the molecular processes that underlie this adaptation is of exceeding importance because most cancer patients die because of metastases rather than primary tumors.
Rampetsreiter P, Casanova E, Eferl R.
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Manipulations with early mouse embryos for generation of genetically modified animals
Вавиловский журнал генетики и селекции, 2017 Recently, genome-editing technologies have become more efficient and accessible. The discovery of nucleases for directional genome editing (CRISPR/Cas9, TALEN, ZFNs) significantly accelerated and simplified the production of mice with targeted gene ...
A. N. Korablev +2 more
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Determination of the Potential Tumor-Suppressive Effects of Gsdme in a Chemically Induced and in a Genetically Modified Intestinal Cancer Mouse Model [PDF]
Cancers, 2019 Gasdermin E (GSDME), also known as deafness autosomal dominant 5 (DFNA5) and previously identified to be an inducer of regulated cell death, is frequently epigenetically inactivated in different cancer types, suggesting that GSDME is a tumor suppressor ...
Lieselot Croes +9 more
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Eradication of Aspiculuris tetraptera in various immunodeficient mouse models using ivermectin: a case report [PDF]
Laboratory Animal ResearchBackground Despite advancements in laboratory animal facility management, pinworm infections remain a persistent issue in immunodeficient mouse colonies.
Ji-Hun Lee +8 more
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Experimental Neurobiology, 2019 Genetically modified mouse models are being used predominantly to understand brain functions and diseases. Well-designed and controlled behavioral analyses of genetically modified mice have successfully led to the identification of gene functions ...
Dong-Hee Kim +3 more
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Two new genetically modified mouse alleles labeling distinct phases of retinal ganglion cell development by fluorescent proteins. [PDF]
Dev Dyn, 2020 Ge Y, Wu F, Cheng M, Bard J, Mu X.
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