Results 11 to 20 of about 226,675 (297)
Genetically modified mouse models for the study of nonalcoholic fatty liver disease. [PDF]
World J Gastroenterol, 2012 Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and type 2 diabetes. NAFLD represents a large spectrum of diseases ranging from (1) fatty liver (hepatic steatosis); (2) steatosis with inflammation and necrosis; to (3) cirrhosis.
Nagarajan P +4 more
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Genetically modified mouse models in studies on cutaneous wound healing [PDF]
Experimental Physiology, 2000 Genetically modified mice have become an invaluable tool in modern biomedical and basic research. This review provides an overview of knockout and transgenic mice studied with regard to their cutaneous wound healing properties. In addition, several gene transfer studies are briefly introduced, which have further highlighted our knowledge on individual ...
Annette Scheid +3 more
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Genetically modified mouse models in studies of luteinising hormone action [PDF]
Molecular and Cellular Endocrinology, 2006 Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH ...
Ilpo Huhtaniemi +5 more
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Two new genetically modified mouse alleles labeling distinct phases of retinal ganglion cell development by fluorescent proteins. [PDF]
Dev Dyn, 2020 Ge Y, Wu F, Cheng M, Bard J, Mu X.
europepmc +3 more sources
Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models. [PDF]
Drug Metab Rev, 2011 Jiang XL, Gonzalez FJ, Yu AM.
europepmc +3 more sources
Ocular surface mucins and local inflammation--studies in genetically modified mouse lines. [PDF]
BMC Ophthalmol, 2015 Shirai K, Saika S.
europepmc +3 more sources
Frontiers in Cell and Developmental Biology, 2023 Osteoarthritis (OA), the most prevalent aging-related joint disease, is characterized by insufficient extracellular matrix synthesis and articular cartilage degradation and is caused by various risk factors including aging and traumatic injury.
Yusuke Fujiwara +15 more
doaj +1 more source
Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane [PDF]
Nature Neuroscience, 2007 Frequency tuning in the cochlea is determined by the passive mechanical properties of the basilar membrane and active feedback from the outer hair cells, sensory-effector cells that detect and amplify sound-induced basilar membrane motions. The sensory hair bundles of the outer hair cells are imbedded in the tectorial membrane, a sheet of extracellular
Ian J. Russell +5 more
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Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse* [PDF]
Epilepsia, 2020 AbstractObjectiveSCN8A encephalopathy is a developmental epileptic encephalopathy typically caused by de novo gain‐of‐function mutations in Nav1.6. Severely affected individuals exhibit refractory seizures, developmental delay, cognitive disabilities, movement disorders, and elevated risk of sudden death.
Wenxi Yu +5 more
openaire +3 more sources
Frontiers in Veterinary Science, 2023 Gene editing tools have become an indispensable part of research into the fundamental aspects of cell biology. With a vast body of literature having been generated based on next generation sequencing technologies, keeping track of this ever-growing body ...
Ali Mazloum +7 more
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