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Genetically modified mouse models in cancer studies
Clinical and Translational Oncology, 2008Genetically modified animals represent a resource of immense potential for cancer research. Classically, genetic modifications in mice were obtained through selected breeding experiments or treatments with powerful carcinogens capable of inducing random mutagenesis.
Pablo Fernández-Navarro +4 more
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Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse
Neuroreport, 2002The autosomal recessive mutation wobbler of the mouse (phenotype WR; genotype wr/wr) causes muscular atrophy due to motoneuron degeneration with 100% penetrance on the standard Mus musculus laboratorius C57BL/6J background. In inter- and backcrosses with M. m.
Ulbrich, Michael +7 more
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Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice [PDF]
, 2016 Highly definable genetically, the humble mouse is the "reagent" mammal of choice with which to probe and begin to understand the human condition in all its complexities. With the recent advance in direct genome editing via targeted nucleases, e.g., TALEN and CRISPR/Cas9, the possibilities in using these sophisticated tools have increased substantially ...
Low, Benjamin E +2 more
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Genetic and Environmental Modifiers of Alzheimers Disease Phenotypes in the Mouse
Current Alzheimer Research, 2006As a group, strains of laboratory mice carrying Alzheimer's disease (AD)-related transgenes are currently the most widely studied animal models of AD. Many AD mouse models carrying the same or similar transgene constructs demonstrate strikingly different phenotypic responses to transgene expression, mimicking the apparent genetic complexity of AD ...
Bruce T. Lamb, Davis Ryman
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Modeling RASopathies with Genetically Modified Mouse Models
2016The RAS/MAPK signaling pathway plays key roles in development, cell survival and proliferation, as well as in cancer pathogenesis. Molecular genetic studies have identified a group of developmental syndromes, the RASopathies, caused by germ line mutations in this pathway.
Isabel Hernández-Porras, Carmen Guerra
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In vivo Studies of the Genetically Modified Mouse Kidney
Nephron Physiology, 2003Gene-targeted mice provide a powerful approach to study the physiological and pathophysiological role of a given protein in kidney function and can give insights on the functional importance of these proteins under in vivo conditions as well as on the potential compensating mechanisms in their absence.
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Genetically modified mouse models for pharmacogenomic research
Nature Reviews Genetics, 2004It is now evident that differences in the DNA sequence of genes involved with drug action can lead to interindividual differences in effectiveness and adverse reactions to therapeutic drugs. Pharmacogenomics raises the possibility that drug discovery and patient management could move from a 'one drug fits all' approach to one in which therapy is ...
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Genetically modified mouse models for oral drug absorption and disposition
Current Opinion in Pharmacology, 2013Intestinal absorption is an essential step in the therapeutic use of most orally administered drugs and often mediated by enterocyte transmembrane transporters. Here we discuss several of these drug transport systems and knockout mouse models to study them.
Jeroen J M A Hendrikx +4 more
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