Results 271 to 280 of about 390,635 (308)

Genetic Modifiers of Cardiac Development 22q11DS Mouse Models

The FASEB Journal, 2016
Over 70% of patients with 22q11.2 Deletion Syndrome (22q11DS) have congenital heart defects. The prevalence and severity of these defects make it critical for us to strive to understand the underlying mechanism of the syndrome by elucidating the gene pathways that are involved in heart development, as their disruption may lead to ...
openaire   +1 more source

Genetically modified mouse models to investigate thyroid development, function and growth

Best Practice & Research Clinical Endocrinology & Metabolism, 2018
The thyroid gland produces thyroid hormones (TH), which are essential regulators for growth, development and metabolism. The thyroid is mainly controlled by the thyroid-stimulating hormone (TSH) that binds to its receptor (TSHR) on thyrocytes and mediates its action via different G protein-mediated signaling pathways.
Kero Andreina, Löf Christoffer, Kero Jukka, Patyra Konrad, Kero Andreina, Kero Jukka   +5 more
openaire   +4 more sources

Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse

Neuroreport, 2002
The autosomal recessive mutation wobbler of the mouse (phenotype WR; genotype wr/wr) causes muscular atrophy due to motoneuron degeneration with 100% penetrance on the standard Mus musculus laboratorius C57BL/6J background. In inter- and backcrosses with M. m.
Ulbrich, Michael, Schmidt, Volker, Ronsiek, Melanie, Mussmann, Anke, Bartsch, Jörg, Augustin, Martin, Jockusch, Harald, Schmitt-John, Thomas   +7 more
openaire   +3 more sources

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

exaly  

Genetically Modified NAT Mouse Models

2018
Kim S. Sugamori, Denis M. Grant
openaire   +1 more source

Humanized mouse models for immuno-oncology research

Nature Reviews Clinical Oncology, 2023
Michael A Brehm
exaly  

Using standard nomenclature to adequately name transgenes, knockout gene alleles and any mutation associated to a genetically modified mouse strain

Transgenic research, 2011
L. Montoliu, C. Bruce A. Whitelaw
semanticscholar   +1 more source

Synthetic alternatives to Matrigel

Nature Reviews Materials, 2020
Elizabeth A Aisenbrey, William L Murphy
exaly  

Intratumoural administration and tumour tissue targeting of cancer immunotherapies

Nature Reviews Clinical Oncology, 2021
Ignacio Melero Bermejo, Eduardo Castanon, Maite Alvarez   +2 more
exaly  

Applications and limitations of genetically modified mouse models in drug discovery and development.

Current drug metabolism, 2008
J. Lin
semanticscholar   +1 more source