Results 281 to 290 of about 277,970 (322)
Some of the next articles are maybe not open access.
Genetically Modified Mouse Models of Adamantinomatous Craniopharyngioma
2017Over the last few years, there have been significant advances in the understanding of the pathogenesis of human adamantinomatous craniopharyngioma. Global and gene-specific expression studies of human biopsies have helped to delineate the network of pathways involved in the initiation and establishment of these tumours.
Cynthia Lilian Andoniadou +1 more
openaire +1 more source
Genetically Modified Mouse Health Reporting: A Need for Global Standardization
Lab Animal, 2003The distribution of GM mice between facilities has raised new problems because of variable microbiological quality. One of the most important management issues concerns the methods of reporting laboratory animal health surveillance results. The authors evaluated the format and content of 380 health reports of mice received from 55 institutions in ...
Juan, Martín-Caballero +2 more
openaire +2 more sources
Regression of atherosclerosis: lessons learned from genetically modified mouse models
Current Opinion in Lipidology, 2018Purpose of review Regression, or reversal, of atherosclerosis has become an important clinical objective. The development of consistent models of murine atherosclerosis regression has accelerated this field of research. The purpose of this review is to highlight recent mouse studies that reveal molecular mechanisms as well as ...
Amy C, Burke, Murray W, Huff
openaire +2 more sources
Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice
2016Highly definable genetically, the humble mouse is the "reagent" mammal of choice with which to probe and begin to understand the human condition in all its complexities. With the recent advance in direct genome editing via targeted nucleases, e.g., TALEN and CRISPR/Cas9, the possibilities in using these sophisticated tools have increased substantially ...
Low, Benjamin E +2 more
openaire +2 more sources
In Vivo Transplantation of Genetically Modified Mouse Embryonic Epidermis
2009Situations in which epidermal mutant mice display early lethality after birth are rather frequent. This condition precludes any kind of analysis of adult or even newborn mice tissues. We propose the in vivo embryonic skin transplantation as an alternative to solve this problem.
Ana Belén, Martínez-Cruz +4 more
openaire +2 more sources
In vivo Studies of the Genetically Modified Mouse Kidney
Nephron Physiology, 2003Gene-targeted mice provide a powerful approach to study the physiological and pathophysiological role of a given protein in kidney function and can give insights on the functional importance of these proteins under in vivo conditions as well as on the potential compensating mechanisms in their absence.
openaire +2 more sources
Mouse Models and Genetic Modifiers in X-Linked Adrenoleukodystrophy
2003X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder that affects 1 in 35000 males and is marked by neurodegeneration, adrenal insufficiency and infertility. All characteristics are not always present in every X-ALD patient and the rate of progression varies.
Ann K, Heinzer +9 more
openaire +2 more sources
Minimizing strain influences in a genetically modified mouse phenotyping platform
Annals of the New York Academy of Sciences, 2011Our approach has been to power studies to allow for detection of at least modest changes from a wild‐type littermate control, include assays with overlapping physiological systems to provide cross‐functional interpretive value, and to employ challenge assays.
Michael D, Hayward +2 more
openaire +2 more sources
Genetically modified mouse models for oral drug absorption and disposition
Current Opinion in Pharmacology, 2013Intestinal absorption is an essential step in the therapeutic use of most orally administered drugs and often mediated by enterocyte transmembrane transporters. Here we discuss several of these drug transport systems and knockout mouse models to study them.
Tang, S.C. +3 more
openaire +3 more sources
Genetic and Environmental Modifiers of Alzheimers Disease Phenotypes in the Mouse
Current Alzheimer Research, 2006As a group, strains of laboratory mice carrying Alzheimer's disease (AD)-related transgenes are currently the most widely studied animal models of AD. Many AD mouse models carrying the same or similar transgene constructs demonstrate strikingly different phenotypic responses to transgene expression, mimicking the apparent genetic complexity of AD ...
Davis, Ryman, Bruce T, Lamb
openaire +2 more sources