Results 281 to 290 of about 522,034 (344)

Bioartificial liver: Where lies the path ahead-A review. [PDF]

Hepatol Commun
Jiang Q, Su Y, Cao X, Zhang H, Zhang J, Li L.   +5 more
europepmc   +1 more source

Generation and expression of high affinity, tumor antigen-specific mouse and human T cell receptors to genetically modify CD8p+s T cells for adoptive immunotherapy of cancer

, 2006
Michelle L. Dossett
openalex   +1 more source

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Modeling RASopathies with Genetically Modified Mouse Models.

Methods in molecular biology, 2017
The RAS/MAPK signaling pathway plays key roles in development, cell survival and proliferation, as well as in cancer pathogenesis. Molecular genetic studies have identified a group of developmental syndromes, the RASopathies, caused by germ line mutations in this pathway.
Isabel Hernández-Porras, C. Guerra
semanticscholar   +3 more sources

Genetically Modified Mouse Models of Adamantinomatous Craniopharyngioma

, 2017
Over the last few years, there have been significant advances in the understanding of the pathogenesis of human adamantinomatous craniopharyngioma. Global and gene-specific expression studies of human biopsies have helped to delineate the network of pathways involved in the initiation and establishment of these tumours.
C. Andoniadou, J. Martínez-Barbera
semanticscholar   +2 more sources

Regression of atherosclerosis: lessons learned from genetically modified mouse models

Current Opinion in Lipidology, 2018
Purpose of review Regression, or reversal, of atherosclerosis has become an important clinical objective. The development of consistent models of murine atherosclerosis regression has accelerated this field of research. The purpose of this review is to highlight recent mouse studies that reveal molecular mechanisms as well as ...
A. Burke, M. Huff
semanticscholar   +3 more sources

Genetically modified mouse models for pharmacogenomic research

Nature Reviews Genetics, 2004
It is now evident that differences in the DNA sequence of genes involved with drug action can lead to interindividual differences in effectiveness and adverse reactions to therapeutic drugs. Pharmacogenomics raises the possibility that drug discovery and patient management could move from a 'one drug fits all' approach to one in which therapy is ...
S. Liggett
semanticscholar   +3 more sources