Results 21 to 30 of about 226,675 (297)
Genetically modified mouse models of cancer invasion and metastasis.
Drug Discov Today Dis Models, 2011 Tumor invasion and metastasis is a multi-step process that requires adaptation of cancer cells to conditions that they encounter during their journey to distant body sites. Understanding the molecular processes that underlie this adaptation is of exceeding importance because most cancer patients die because of metastases rather than primary tumors.
Rampetsreiter P, Casanova E, Eferl R.
europepmc +3 more sources
Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance Our current understanding of genetic disease is often inadequate, largely due to genetic background effects that modify disease presentation. This is particularly challenging for rare diseases that lack sufficient numbers of patients for genome-wide association studies.
Ramsbottom, Simon +14 more
openaire +5 more sources
Generation of an immortalized mouse embryonic palatal mesenchyme cell line. [PDF]
PLoS ONE, 2017 Palatogenesis is a complex morphogenetic process, disruptions in which result in highly prevalent birth defects in humans. In recent decades, the use of model systems such as genetically-modified mice, mouse palatal organ cultures and primary mouse ...
Katherine A Fantauzzo, Philippe Soriano
doaj +1 more source
Animal models for COVID-19: advances, gaps and perspectives
Signal Transduction and Targeted Therapy, 2022 COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this century. Since the outbreak in late 2019, animal models have been playing crucial roles in aiding the rapid development of vaccines/drugs for prevention and therapy, as well as ...
Changfa Fan +7 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2020 The UCSF Mouse Inventory Database Application is an open-source Web App that provides information about the mutant alleles, transgenes, and inbred strains maintained by investigators at the university and facilitates sharing of these resources within the
Estelle Wall +7 more
doaj +1 more source
Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery
Nature Communications, 2020 CRISPR/Cas9 technology has revolutionised the ability of scientists to make genetically modified cells and animal models. Here, the authors make a Tet-On genetically modified mouse using the Streptococcus pyogenes Cas9 and demonstrate that it can be used
Anders Lundin +23 more
doaj +1 more source
The EuroBiotech Journal, 2022 Genetically modified mice are engineered as models for human diseases. These mouse models include inbred strains, mutants, gene knockouts, gene knockins, and ‘humanized’ mice.
Brown Richard E.
doaj +1 more source
OncoImmunology, 2022 The enzyme glutaminyl-peptide cyclotransferase-like protein (QPCTL) catalyzes the formation of pyroglutamate residues at the NH2-terminus of proteins, thereby influencing their biological properties.
Kaspar Bresser +8 more
doaj +1 more source
Genetic Modifiers of Retinal Degeneration in therd3Mouse [PDF]
Investigative Opthalmology & Visual Science, 2008 In previous studies of light-induced (LRD) and age-related (ageRD) retinal degeneration (RD) between the BALB/cByJ (BALB) and B6(Cg)-Tyr(c-2J)/J (B6a) albino mouse strains, RD-modifying quantitative trait loci (QTLs) were identified. After breeding BALB- and B6a-rd3/rd3 congenic strains and finding significant differences in RD, an F1 intercross to ...
Robert W. Williams +8 more
openaire +3 more sources
Cells, 2021 In mammals, the neuroendocrine system, which includes the communication between the hypothalamus and the pituitary, plays a major role in controlling body growth and cellular metabolism. GH produced from the pituitary somatotroph is considered the master
Sarmed Al-Samerria, Sally Radovick
doaj +1 more source