Novel Genetically Modified Mouse Model to Assess Soman-Induced Toxicity and Medical Countermeasure Efficacy: Human Acetylcholinesterase Knock-in Serum Carboxylesterase Knockout Mice. [PDF]
Int J Mol Sci, 2021 Marrero-Rosado BM +5 more
europepmc +3 more sources
Genetically Modified Mouse Models Used for Studying the Role of the AT2Receptor in Cardiac Hypertrophy and Heart Failure [PDF]
Journal of Biomedicine and Biotechnology, 2011 The actions of Angiotensin II have been implicated in many cardiovascular conditions. It is widely accepted that the cardiovascular effects of Angiotensin II are mediated by different subtypes of receptors: AT1 and AT2.
Maria Del Nogal Avila +2 more
openalex +2 more sources
Simultaneous detection of multiple transgenes for genetically-modified mouse strains.
Experimental Animals, 2009 Recent advances in the genetic manipulation of mice have enabled us to generate transgenic and knockout mice. However, it is not easy to maintain these genetically-modified mice with the high-quality necessary to meet both scientific and legal requirements. RIKEN BRC has collected various transgenic, knockout, and conditional knockout mice.
Hatsumi Nakata +5 more
semanticscholar +4 more sources
Genetic background modifies amyloidosis in a mouse model of ATTR neuropathy
Biochemistry and Biophysics Reports, 2016 Penetrance and age of onset of ATTRV30M amyloidotic neuropathy varies significantly among different populations. This variability has been attributed to both genetic and environmental modifiers. We studied the effect of genetic background on phenotype in two lines of transgenic mice bearing the same ATTRV30M transgene. Amyloid deposition, transthyretin
Elena Panayiotou +7 more
openalex +3 more sources
Genetically modified mouse models in studies of luteinising hormone action
Molecular and Cellular Endocrinology, 2006 Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH ...
I. Huhtaniemi +5 more
semanticscholar +4 more sources
In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models. [PDF]
Mol Imaging Biol, 2017 Russell J +7 more
europepmc +2 more sources
Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model. [PDF]
, 2015 Colon cancer liver metastasis is often the lethal aspect of this disease. Well-isolated metastases are candidates for surgical resection, but recurrence is common. Better adjuvant treatment is therefore needed to reduce or prevent recurrence.
Bouvet, Michael +8 more
core +21 more sources
Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease [PDF]
Genes, Brain and Behavior, 2005 Dione Kobayashi, Kuen‐Suan Chen
openalex +2 more sources
Dissecting the Roles of Gonadotropin-Inhibitory Hormone in Mammals: Studies Using Pharmacological Tools and Genetically Modified Mouse Models. [PDF]
Front Endocrinol (Lausanne), 2015 Leon S, Tena-Sempere M.
europepmc +2 more sources
Frontiers in Cell and Developmental Biology, 2023 Osteoarthritis (OA), the most prevalent aging-related joint disease, is characterized by insufficient extracellular matrix synthesis and articular cartilage degradation and is caused by various risk factors including aging and traumatic injury.
Yusuke Fujiwara +15 more
doaj +1 more source