Results 21 to 30 of about 277,970 (322)
Frontiers in Cell and Developmental Biology, 2023 Osteoarthritis (OA), the most prevalent aging-related joint disease, is characterized by insufficient extracellular matrix synthesis and articular cartilage degradation and is caused by various risk factors including aging and traumatic injury.
Yusuke Fujiwara +15 more
doaj +1 more source
Frontiers in Veterinary Science, 2023 Gene editing tools have become an indispensable part of research into the fundamental aspects of cell biology. With a vast body of literature having been generated based on next generation sequencing technologies, keeping track of this ever-growing body ...
Ali Mazloum +7 more
doaj +1 more source
Genetically modified mouse models addressing gonadotropin function
Reproductive Biology, 2014 The development of genetically modified animals has been useful to understand the mechanisms involved in the regulation of the gonadotropin function. It is well known that alterations in the secretion of a single hormone is capable of producing profound reproductive abnormalities.
Laura D. Ratner +2 more
+7 more sources
Generation of an immortalized mouse embryonic palatal mesenchyme cell line. [PDF]
PLoS ONE, 2017 Palatogenesis is a complex morphogenetic process, disruptions in which result in highly prevalent birth defects in humans. In recent decades, the use of model systems such as genetically-modified mice, mouse palatal organ cultures and primary mouse ...
Katherine A Fantauzzo, Philippe Soriano
doaj +1 more source
Animal models for COVID-19: advances, gaps and perspectives
Signal Transduction and Targeted Therapy, 2022 COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this century. Since the outbreak in late 2019, animal models have been playing crucial roles in aiding the rapid development of vaccines/drugs for prevention and therapy, as well as ...
Changfa Fan +7 more
doaj +1 more source
Testing genetically modified food in mouse models
, 2013 Mit Hilfe der Gentechnik ist es möglich gezielte Erbinformationen in Nutzpflanzen zu ändern. In der australischen CSIRO Plant Industrie wurde die genetisch veränderte Nutzpflanze (Pisum sativum) entwickelt. Wissenschaftliche Ergebnisse zeigten, dass das Protein α-Amylase-Inhibitor (AAI) vorkommend in Bohnen, Pflanzen vor schädlichen Käfern beschützt ...
Hui-Yi Lee
openalex +2 more sources
Genetically modified mouse models for the study of nonalcoholic fatty liver disease. [PDF]
World J Gastroenterol, 2012 Nagarajan P +4 more
europepmc +3 more sources
Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance Our current understanding of genetic disease is often inadequate, largely due to genetic background effects that modify disease presentation. This is particularly challenging for rare diseases that lack sufficient numbers of patients for genome-wide association studies.
Ramsbottom, Simon +14 more
openaire +4 more sources
CRISPR/Cas9‐mediated genome editing: from basic research to translational medicine [PDF]
, 2020 The recent development of the CRISPR/Cas9 system as an efficient and accessible programmable genome-editing tool has revolutionized basic science research. CRISPR/Cas9 system-based technologies have armed researchers with new powerful tools to unveil the
Ferreira, B I +2 more
core +1 more source
G3: Genes, Genomes, Genetics, 2020 The UCSF Mouse Inventory Database Application is an open-source Web App that provides information about the mutant alleles, transgenes, and inbred strains maintained by investigators at the university and facilitates sharing of these resources within the
Estelle Wall +7 more
doaj +1 more source