Novel Genetically Modified Mouse Model to Assess Soman-Induced Toxicity and Medical Countermeasure Efficacy: Human Acetylcholinesterase Knock-in Serum Carboxylesterase Knockout Mice. [PDF]
Int J Mol Sci, 2021 Marrero-Rosado BM +5 more
europepmc +3 more sources
Genetically modified mouse models addressing gonadotropin function.
Reproductive Biology, 2014 The development of genetically modified animals has been useful to understand the mechanisms involved in the regulation of the gonadotropin function. It is well known that alterations in the secretion of a single hormone is capable of producing profound reproductive abnormalities.
L. Ratner, S. Rulli, I. Huhtaniemi
semanticscholar +7 more sources
Genetically Modified Mouse Models Used for Studying the Role of the AT2Receptor in Cardiac Hypertrophy and Heart Failure [PDF]
Journal of Biomedicine and Biotechnology, 2011 The actions of Angiotensin II have been implicated in many cardiovascular conditions. It is widely accepted that the cardiovascular effects of Angiotensin II are mediated by different subtypes of receptors: AT1 and AT2.
Maria Del Nogal Avila +2 more
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In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models. [PDF]
Mol Imaging Biol, 2017 Russell J +7 more
europepmc +2 more sources
Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease [PDF]
Genes, Brain and Behavior, 2005 Dione Kobayashi, Kuen‐Suan Chen
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Dissecting the Roles of Gonadotropin-Inhibitory Hormone in Mammals: Studies Using Pharmacological Tools and Genetically Modified Mouse Models. [PDF]
Front Endocrinol (Lausanne), 2015 Leon S, Tena-Sempere M.
europepmc +2 more sources
Frontiers in Cell and Developmental Biology, 2023 Osteoarthritis (OA), the most prevalent aging-related joint disease, is characterized by insufficient extracellular matrix synthesis and articular cartilage degradation and is caused by various risk factors including aging and traumatic injury.
Yusuke Fujiwara +15 more
doaj +1 more source
Frontiers in Veterinary Science, 2023 Gene editing tools have become an indispensable part of research into the fundamental aspects of cell biology. With a vast body of literature having been generated based on next generation sequencing technologies, keeping track of this ever-growing body ...
Ali Mazloum +7 more
doaj +1 more source
Generation of an immortalized mouse embryonic palatal mesenchyme cell line. [PDF]
PLoS ONE, 2017 Palatogenesis is a complex morphogenetic process, disruptions in which result in highly prevalent birth defects in humans. In recent decades, the use of model systems such as genetically-modified mice, mouse palatal organ cultures and primary mouse ...
Katherine A Fantauzzo, Philippe Soriano
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Animal models for COVID-19: advances, gaps and perspectives
Signal Transduction and Targeted Therapy, 2022 COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this century. Since the outbreak in late 2019, animal models have been playing crucial roles in aiding the rapid development of vaccines/drugs for prevention and therapy, as well as ...
Changfa Fan +7 more
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