Results 51 to 60 of about 390,635 (308)
Advances in Genome Editing and Application to the Generation of Genetically Modified Rat Models
Frontiers in Genetics, 2021 The rat has been extensively used as a small animal model. Many genetically engineered rat models have emerged in the last two decades, and the advent of gene-specific nucleases has accelerated their generation in recent years.
Vanessa Chenouard +6 more
semanticscholar +1 more source
Efficient DNA knock-in using AAV-mediated delivery with 2-cell embryo CRISPR-Cas9 electroporation
Frontiers in Genome Editing, 2023 Recent advances in CRISPR-Cas genome editing technology have been instrumental in improving the efficiency to produce genetically modified animal models.
Daniel J. Davis +6 more
doaj +1 more source
Genetic Modifiers of Retinal Degeneration in therd3Mouse [PDF]
Investigative Opthalmology & Visual Science, 2008 In previous studies of light-induced (LRD) and age-related (ageRD) retinal degeneration (RD) between the BALB/cByJ (BALB) and B6(Cg)-Tyr(c-2J)/J (B6a) albino mouse strains, RD-modifying quantitative trait loci (QTLs) were identified. After breeding BALB- and B6a-rd3/rd3 congenic strains and finding significant differences in RD, an F1 intercross to ...
Michael, Danciger +8 more
openaire +2 more sources
Genetic platelet depletion is superior in platelet transfusion compared to current models
Haematologica, 2020 Genetically modified mice have advanced our knowledge on platelets in hemostasis and beyond tremendously. However, mouse models harbor certain limitations, including availability of platelet specific transgenic strains, and off-target effects on other ...
Manuel Salzmann +11 more
doaj +1 more source
Cancer immunoprevention: from mice to early clinical trials
BMC Immunology, 2018 Cancer immunoprevention is based on the fact that a functioning immune system controls tumor onset and development in humans and animals, thus leading to the idea that the enhancement of immune responses in healthy individuals could effectively reduce ...
Arianna Palladini +3 more
doaj +1 more source
An open-source video tracking system for mouse locomotor activity analysis
BMC Research Notes, 2020 Objective The ability to accurately and efficiently quantify mouse locomotor activity is essential for evaluating therapeutic efficacy and phenotyping genetically modified mice, in particular for the research of neuromuscular diseases.
Chen Zhang, Haiwen Li, Renzhi Han
doaj +1 more source
Molecular Therapy: Oncolytics, 2022 Malignant soft tissue tumors, particularly highly malignant leiomyosarcomas, are resistant to chemotherapy and associated with a poor prognosis. T-01, a third-generation genetically modified herpes simplex virus type 1, replicates in tumor cells alone ...
Masahiko Hatta +8 more
doaj +1 more source
Blood-testis barrier and spermatogenesis: lessons from genetically-modified mice
Asian Journal of Andrology, 2014 The blood-testis barrier (BTB) is found between adjacent Sertoli cells in the testis where it creates a unique microenvironment for the development and maturation of meiotic and postmeiotic germ cells in seminiferous tubes.
Xiao-Hua Jiang +6 more
doaj +1 more source
Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
Nature Communications, 2018 Structural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhanced ...
Adam C. Frank +10 more
doaj +1 more source
Maternal Supply of Cas9 to Zygotes Facilitates the Efficient Generation of Site-Specific Mutant Mouse Models. [PDF]
PLoS ONE, 2017 Genome manipulation in the mouse via microinjection of CRISPR/Cas9 site-specific nucleases has allowed the production time for genetically modified mouse models to be significantly reduced.
Alberto Cebrian-Serrano +5 more
doaj +1 more source