Multifunctional fiber-based optoacoustic emitter for non-genetic bidirectional neural communication [PDF]
arXiv, 2023 A bidirectional brain interface with both "write" and "read" functions can be an important tool for fundamental studies and potential clinical treatments for neurological diseases. Here we report a miniaturized multifunctional fiber based optoacoustic emitter (mFOE) that first integrates simultaneous non-genetic optoacoustic stimulation for "write" and
arxiv
Blood-testis barrier and spermatogenesis: lessons from genetically-modified mice
Asian Journal of Andrology, 2014 The blood-testis barrier (BTB) is found between adjacent Sertoli cells in the testis where it creates a unique microenvironment for the development and maturation of meiotic and postmeiotic germ cells in seminiferous tubes.
Xiao-Hua Jiang +6 more
doaj +1 more source
Maternal Supply of Cas9 to Zygotes Facilitates the Efficient Generation of Site-Specific Mutant Mouse Models. [PDF]
PLoS ONE, 2017 Genome manipulation in the mouse via microinjection of CRISPR/Cas9 site-specific nucleases has allowed the production time for genetically modified mouse models to be significantly reduced.
Alberto Cebrian-Serrano +5 more
doaj +1 more source
sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification
Frontiers in Cell and Developmental Biology, 2022 Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the tempo of obtaining genetic mouse models due to high efficiency.
Lichen Zhang +25 more
doaj +1 more source
A structural model of genome-wide association studies [PDF]
arXiv, 2022 A structural genetic model incorporating a modern understanding of the genome and common practice in genome-wide association studies is derived mathematically. The model shows the Haldane map distance as a direct consequence of the structure of the genome.
arxiv
Two-Parameter Characterization of Chromosome-Scale Recombination Rate [PDF]
Genome Research, 19:2300-2307 (2009), 2009 The genome-wide recombination rate ($RR$) of a species is often described by one parameter, the ratio between total genetic map length ($G$) and physical map length ($P$), measured in centiMorgans per Megabase (cM/Mb). The value of this parameter varies greatly between species, but the cause for these differences is not entirely clear.
arxiv +1 more source
Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
Nature Communications, 2018 Structural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhanced ...
Adam C. Frank +10 more
doaj +1 more source
Genomic Data Analysis using a Two Stage Expectation Propagation Algorithm for Analysis of Sparse Bayesian High-Dimensional Instrumental Variables Regression [PDF]
arXiv, 2021 Simultaneous analysis of gene expression data and genetic variants is highly of interest, especially when the number of gene expressions and genetic variants are both greater than the sample size. Association of both causal genes and effective SNPs makes the use of sparse modeling of such genetic data sets, highly important. The high-dimensional sparse
arxiv
TranspoGene and microTranspoGene: transposed elements influence on the transcriptome of seven vertebrates and invertebrates [PDF]
Nucleic Acids Research, 2008, Vol 36, 2008 Transposed elements (TEs) are mobile genetic sequences. During the evolution of eukaryotes TEs were inserted into active protein-coding genes, affecting gene structure, expression and splicing patterns, and protein sequences. Genomic insertions of TEs also led to creation and expression of new functional non-coding RNAs such as micro- RNAs.
arxiv +1 more source
Genetic background modifies amyloidosis in a mouse model of ATTR neuropathy
Biochemistry and Biophysics Reports, 2016 Penetrance and age of onset of ATTRV30M amyloidotic neuropathy varies significantly among different populations. This variability has been attributed to both genetic and environmental modifiers. We studied the effect of genetic background on phenotype in two lines of transgenic mice bearing the same ATTRV30M transgene. Amyloid deposition, transthyretin
Panayiotou, E. +7 more
openaire +2 more sources