Results 51 to 60 of about 140,816 (272)

Genetic background modifies amyloidosis in a mouse model of ATTR neuropathy

Biochemistry and Biophysics Reports, 2016
Penetrance and age of onset of ATTRV30M amyloidotic neuropathy varies significantly among different populations. This variability has been attributed to both genetic and environmental modifiers. We studied the effect of genetic background on phenotype in two lines of transgenic mice bearing the same ATTRV30M transgene. Amyloid deposition, transthyretin
Panayiotou, E., Papacharalambous, R., Antoniou, A., Christophides, G., Papageorgiou, L., Fella, E., Malas, S., Kyriakides, T.   +7 more
openaire   +2 more sources

Development of HPV16 mouse and dog models for more accurate prediction of human vaccine efficacy

Laboratory Animal Research, 2023
Background Animal models are essential to understand the physiopathology of human diseases but also to evaluate new therapies. However, for several diseases there is no appropriate animal model, which complicates the development of effective therapies ...
Emmanuelle Totain, Loïc Lindner, Nicolas Martin, Yolande Misseri, Alexandra Iché, Marie-Christine Birling, Tania Sorg, Yann Herault, Alain Bousquet-Melou, Pascale Bouillé, Christine Duthoit, Guillaume Pavlovic, Severine Boullier   +12 more
doaj   +1 more source

In vivo Tumor Growth and Spontaneous Metastasis Assays Using A549 Lung Cancer Cells

Bio-Protocol, 2020
Metastasis accounts for the majority of cancer related deaths. The genetically engineered mouse (GEM) models and cell line-based subcutaneous and orthotopic mouse xenografts have been developed to study the metastatic process.
Lei Qi, Teresa Knifley, Dava Piecoro, Piotr Rychahou, Jianrong Wu, Kathleen O'Connor, Min Chen   +6 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Antinociceptive effect of intrathecal injection of miR-9-5p modified mouse bone marrow mesenchymal stem cells on a mouse model of bone cancer pain

Journal of Neuroinflammation, 2020
Background A growing body of studies have indicated that bone marrow mesenchymal stem cells (BMSCs) have powerful analgesic effects in animal models of bone cancer pain.
Chao Zhu, Kun Wang, Zhi Chen, Yingchao Han, Hao Chen, Quan Li, Zude Liu, Lie Qian, Jun Tang, Hongxing Shen   +9 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Unraveling Genetic Modifiers in the Gria4 Mouse Model of Absence Epilepsy

PLoS Genetics, 2014
Absence epilepsy (AE) is a common type of genetic generalized epilepsy (GGE), particularly in children. AE and GGE are complex genetic diseases with few causal variants identified to date. Gria4 deficient mice provide a model of AE, one for which the common laboratory inbred strain C3H/HeJ (HeJ) harbors a natural IAP retrotransposon insertion in Gria4 ...
Frankel, Wayne N, Mahaffey, Connie L, McGarr, Tracy C, Beyer, Barbara J, Letts, Verity A   +4 more
openaire   +6 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

A Genetic Screen for Modifiers of the Delta1-Dependent Notch Signaling Function in the Mouse [PDF]

Genetics, 2007
AbstractThe Notch signaling pathway is an evolutionarily conserved transduction pathway involved in embryonic patterning and regulation of cell fates during development. Recent studies have demonstrated that this pathway is integral to a complex system of interactions, which are also involved in distinct human diseases.
Rubio-Aliaga, Isabel, Soewarto, Dian, Wagner, Sibylle, Klaften, Matthias, Fuchs, Helmut, Kalaydjiev, Svetoslav, Busch, Dirk H., Klempt, Martina, Rathkolb, Birgit, Wolf, Eckhard, Abe, Koichiro, Zeiser, Stefan, Przemeck, Gerhard K H, Beckers, Johannes, De Angelis, Martin Hrabé   +14 more
openaire   +4 more sources

Functional genetic dropout screens and in vivo validation of candidate therapeutic targets using mouse mammary tumoroids

STAR Protocols, 2022
Summary: We have previously developed 3D tumoroids derived from genetically engineered mouse models (GEMMs) of BRCA1/2-deficient breast cancer. Here, we describe how to genetically modify tumoroids, use them for functional genetic dropout screens, and ...
Mariana Paes Dias, Sven Rottenberg, Jos Jonkers   +2 more
doaj