Results 71 to 80 of about 277,970 (322)

sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification

Frontiers in Cell and Developmental Biology, 2022
Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the tempo of obtaining genetic mouse models due to high efficiency.
Lichen Zhang, Lichen Zhang, Wushan Li, Wushan Li, Zhuangzhuang Liu, Zhuangzhuang Liu, Yang Liu, Yang Liu, Zhilong Liu, Zhilong Liu, Yanrong Gu, Yanrong Gu, Le He, Le He, Binhui Zhou, Binhui Zhou, Tianhan Li, Tianhan Li, Tianzhu Chao, Tianzhu Chao, Yinming Liang, Yinming Liang, Yinming Liang, Liaoxun Lu, Liaoxun Lu, Liaoxun Lu   +25 more
doaj   +1 more source

Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex. [PDF]

, 1994
Induction of tolerance to allogeneic MHC antigens has been a goal in the field of transplantation because it would reduce or eliminate the need for generalized immunosuppression.
Geissler, Edward K., Jiao, Shoushu, Knechtle, Stuart J., Sumimoto, Ryo, Wang, Jue, Wolff, Jon   +5 more
core   +1 more source

Antinociceptive effect of intrathecal injection of miR-9-5p modified mouse bone marrow mesenchymal stem cells on a mouse model of bone cancer pain

Journal of Neuroinflammation, 2020
Background A growing body of studies have indicated that bone marrow mesenchymal stem cells (BMSCs) have powerful analgesic effects in animal models of bone cancer pain.
Chao Zhu, Kun Wang, Zhi Chen, Yingchao Han, Hao Chen, Quan Li, Zude Liu, Lie Qian, Jun Tang, Hongxing Shen   +9 more
doaj   +1 more source

Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research [PDF]

, 2019
Hypertension is ranked as the third cause of disability-adjusted life-years. The percentage of the population suffering from hypertension will continue to increase over the next years.
Schleifenbaum, Johanna, Zhong, Cheng
core   +1 more source

Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse* [PDF]

Epilepsia, 2020
AbstractObjectiveSCN8A encephalopathy is a developmental epileptic encephalopathy typically caused by de novo gain‐of‐function mutations in Nav1.6. Severely affected individuals exhibit refractory seizures, developmental delay, cognitive disabilities, movement disorders, and elevated risk of sudden death.
Wenxi Yu, Sophie F. Hill, James G. Xenakis, Fernando Pardo‐Manuel de Villena, Jacy L. Wagnon, Miriam H. Meisler   +5 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Development of HPV16 mouse and dog models for more accurate prediction of human vaccine efficacy

Laboratory Animal Research, 2023
Background Animal models are essential to understand the physiopathology of human diseases but also to evaluate new therapies. However, for several diseases there is no appropriate animal model, which complicates the development of effective therapies ...
Emmanuelle Totain, Loïc Lindner, Nicolas Martin, Yolande Misseri, Alexandra Iché, Marie-Christine Birling, Tania Sorg, Yann Herault, Alain Bousquet-Melou, Pascale Bouillé, Christine Duthoit, Guillaume Pavlovic, Severine Boullier   +12 more
doaj   +1 more source

Cancer vaccines: uses of HLA transgenic mice compared to genetically modified mice [PDF]

, 2008
Many tumor antigens have been identified that can be targeted by the immune system. Animal models that have been genetically modified to express human HLA molecules instead of their own MHC antigens have shown to be valuable in the discovery of peptides ...
McArdle, SE
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source