Results 71 to 80 of about 522,034 (344)

DNA fragmentation index (DFI) as a measure of sperm quality and fertility in mice. [PDF]

, 2020
Although thousands of genetically modified mouse strains have been cryopreserved by sperm freezing, the likelihood of cryorecovery success cannot be accurately predicted using conventional sperm parameters.
Li, Ming-Wen, Lloyd, KC Kent
core   +1 more source

Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory

Nature Communications, 2018
Structural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhanced ...
Adam C. Frank, Shan Huang, Miou Zhou, Amos Gdalyahu, George Kastellakis, Tawnie K. Silva, Elaine Lu, Ximiao Wen, Panayiota Poirazi, Joshua T. Trachtenberg, Alcino J. Silva   +10 more
doaj   +1 more source

Maternal Supply of Cas9 to Zygotes Facilitates the Efficient Generation of Site-Specific Mutant Mouse Models. [PDF]

PLoS ONE, 2017
Genome manipulation in the mouse via microinjection of CRISPR/Cas9 site-specific nucleases has allowed the production time for genetically modified mouse models to be significantly reduced.
Alberto Cebrian-Serrano, Shijun Zha, Lars Hanssen, Daniel Biggs, Christopher Preece, Benjamin Davies   +5 more
doaj   +1 more source

sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification

Frontiers in Cell and Developmental Biology, 2022
Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the tempo of obtaining genetic mouse models due to high efficiency.
Lichen Zhang, Lichen Zhang, Wushan Li, Wushan Li, Zhuangzhuang Liu, Zhuangzhuang Liu, Yang Liu, Yang Liu, Zhilong Liu, Zhilong Liu, Yanrong Gu, Yanrong Gu, Le He, Le He, Binhui Zhou, Binhui Zhou, Tianhan Li, Tianhan Li, Tianzhu Chao, Tianzhu Chao, Yinming Liang, Yinming Liang, Yinming Liang, Liaoxun Lu, Liaoxun Lu, Liaoxun Lu   +25 more
doaj   +1 more source

Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation [PDF]

, 2006
The planar cell polarity (PCP) pathway is conserved throughout evolution, but it mediates distinct developmental processes. In Drosophila, members of the PCP pathway localize in a polarized fashion to specify the cellular polarity within the plane of the
Brinkman, Brendan C., Chen, Ping, Dickinson, Mary E., Fraser, Scott E., Hamblet, Natasha S., Mark, Sharayne, Segil, Neil, Wallingford, John B., Wang, Jianbo, Wynshaw-Boris, Anthony   +9 more
core   +1 more source

Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome. [PDF]

, 2020
Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by developmental delay, impaired communication, motor deficits and ataxia, intellectual disabilities, microcephaly, and seizures. The genetic cause of AS is the loss of expression
Adhikari, A, Anderson, AE, Beitnere, U, Berg, EL, Born, HA, Cameron, DL, Copping, NA, Deng, P, Dindot, SV, Ellegood, J, Fenton, TA, Fink, KD, Harris, S, Lee, RD, Lerch, JP, Nash, KR, Nieman, BJ, Noakes, LS, O'Geen, H, Pedersen, LR, Peters, MM, Petkova, SP, Pride, MC, Segal, DJ, Shen, Y, Silverman, JL, Weeber, EJ, Wöhr, M   +27 more
core   +2 more sources

Development of HPV16 mouse and dog models for more accurate prediction of human vaccine efficacy

Laboratory Animal Research, 2023
Background Animal models are essential to understand the physiopathology of human diseases but also to evaluate new therapies. However, for several diseases there is no appropriate animal model, which complicates the development of effective therapies ...
Emmanuelle Totain, Loïc Lindner, Nicolas Martin, Yolande Misseri, Alexandra Iché, Marie-Christine Birling, Tania Sorg, Yann Herault, Alain Bousquet-Melou, Pascale Bouillé, Christine Duthoit, Guillaume Pavlovic, Severine Boullier   +12 more
doaj   +1 more source

Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse* [PDF]

Epilepsia, 2020
AbstractObjectiveSCN8A encephalopathy is a developmental epileptic encephalopathy typically caused by de novo gain‐of‐function mutations in Nav1.6. Severely affected individuals exhibit refractory seizures, developmental delay, cognitive disabilities, movement disorders, and elevated risk of sudden death.
Wenxi Yu, Sophie F. Hill, James G. Xenakis, Fernando Pardo‐Manuel de Villena, Jacy L. Wagnon, Miriam H. Meisler   +5 more
openaire   +2 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Antinociceptive effect of intrathecal injection of miR-9-5p modified mouse bone marrow mesenchymal stem cells on a mouse model of bone cancer pain

Journal of Neuroinflammation, 2020
Background A growing body of studies have indicated that bone marrow mesenchymal stem cells (BMSCs) have powerful analgesic effects in animal models of bone cancer pain.
Chao Zhu, Kun Wang, Zhi Chen, Yingchao Han, Hao Chen, Quan Li, Zude Liu, Lie Qian, Jun Tang, Hongxing Shen   +9 more
doaj   +1 more source