Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis
Advanced Healthcare Materials, EarlyView.This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han +7 more
wiley +1 more source
Novel GMO-Based Vaccines against Tuberculosis: State of the Art and Biosafety Considerations
Vaccines, 2014 Novel efficient vaccines are needed to control tuberculosis (TB), a major cause of morbidity and mortality worldwide. Several TB vaccine candidates are currently in clinical and preclinical development.
Amaya Leunda +5 more
doaj +1 more source
The Precautionary Principle Applied to Deliberate Release of Genetically Modified Organisms (GMOs) [PDF]
, 1999 Anne Ingeborg Myhr
openalex +1 more source
Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response
Advanced Healthcare Materials, EarlyView.In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim +11 more
wiley +1 more source
Engineering species-like barriers to sexual reproduction
Nature Communications, 2017 Genetic isolation of a genetically modified organism represents a useful strategy for biocontainment. Here the authors use dCas9-VP64-driven gene expression to construct a ‘species-like’ barrier to reproduction between two otherwise compatible ...
Maciej Maselko +4 more
doaj +1 more source
Safety assessment of viable genetically modified micro-organisms used in food [PDF]
, 1999 openalex +1 more source
A review of knowledge of the potential impacts of GMOs on organic agriculture [PDF]
, 2001 The organic movement believes that organic agriculture, by its nature, cannot involve the use of genetically modified organisms (GMOs). This has been incorporated into EU regulations which state that there is no place in organic agriculture for GMOs ...
Clarke, Belinda +5 more
core
Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo
Advanced Healthcare Materials, EarlyView.This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla +16 more
wiley +1 more source
Bioplastics: Acceptable for the Packaging of Organic Food? A Policy Analysi
Journal of Agriculture, Food Systems, and Community Development, 2016 Bioplastics have been introduced as an alternative to petro-based plastics and to provide packaging materials with improved biodegradability and compostability.
Ching-Hua Yeh +2 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Biomimetic, suturable, biodegradable fibrous scaffolds are engineered to mimic the tensile properties of LUT tissue using photocrosslinked 5:5% weight per volume elastin‐like peptide and methacrylated gelatin (5E5G). In vitro, urothelium, smooth muscle, and fibroblast 7 day cytocompatibility is demonstrated.
Renea M. Sturm +18 more
wiley +1 more source