Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
"Are genetically modified foods bad for my health?". Individuals' valutation and the choice among different information sources [PDF]
We investigate the role of information on consumers’ valuation for food products containing genetically modified organisms (GMOs), using data from a specifically designed survey. We provide three main results.
Sergio Beraldo +2 more
core
Post Market Monitoring: Legal Framework in Brazil and First Results(Contribution to the 4th International Workshop on PMEM of Genetically Modified Plants, Quedlinburg) [PDF]
, 2011 Brasilien war 2010 der zweitgrößte Anbauer von gentechnisch veränderten Pflanzen. Die rechtliche Basis für die Forschung und kommerzielle Freisetzung von gentechnisch veränderten Organismen geht zurück auf das Jahr 2005.
Andrade, Paulo P. +2 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Statement on in vitro protein digestibility tests in allergenicity and protein safety assessment of genetically modified plants. [PDF]
EFSA J, 2021 EFSA Panel on Genetically Modified Organisms (GMO) +17 more
europepmc +1 more source
The importance of risk assessment of genetically modified plants
Current Opinion in Biotechnology, 2011 Öz bulunamadı.
openaire +2 more sources
Is it Who You Ask or How You Ask? Findings of a Meta-Analysis on Genetically Modified Food Valuation Studies [PDF]
This paper presents a meta-analysis of 46 primary studies reporting a total of 108 genetically modified food valuation estimates. The analysis shows that elicitation methods and formats used in the primary studies affect valuation estimates much more ...
Dannenberg, Astrid
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Evaluation of existing guidelines for their adequacy for the molecular characterisation and environmental risk assessment of genetically modified plants obtained through synthetic biology. [PDF]
EFSA J, 2021 EFSA Panel on Genetically Modified Organisms (GMO) +26 more
europepmc +1 more source