Results 121 to 130 of about 3,336,192 (297)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Developing a good practice for the review of evidence relevant to GMO risk assessment

, 2013
Recent controversies over peer-reviewed papers on potential impacts of genetically modified organisms underline the necessity for an explicit, transparent and unbiased reviewing of published results. Evidence synthesis approaches represent powerful tools
Kohl, Christian, Kleter, Gijs A., Spök, Armin, Garcia-Yi, Jaqueline, Craig, Wendy, Romeis, Jörg, Wilhelm, Ralf, Frampton, Geoff, van Herck, Kristine, Sweet, Jeremy, Meissle, Michael, Schiemann, Joachim, Krogh, Paul Henning   +12 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Impact of genetically modified organisms on meat quality

Open Veterinary Journal
A unique class of gene biotechnology known as genetic modification modifies the genetic makeup of living things like microbes, plants, and animals. Several possible advantages and hazards associated with gene biotechnology. Due to increased food demands
Muntaha Ghazi Hasan
doaj   +1 more source

An Analysis of McLean County, Illinois Farmers' Perceptions of Genetically Modified Crops [PDF]

McLean County, Illinois farmers were surveyed in order to explore and analyze their perceptions of genetically modified crops and their genetically modified cropping decisions.
Chimmiri, Nagesh, Tudor, Kerry W., Spaulding, Aslihan D.   +2 more
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Genetically Modified Plants: Nutritious, Sustainable, yet Underrated. [PDF]

J Nutr, 2020
Hirschi KD.
europepmc   +1 more source

Genetically modified plants are an alternative to oily fish for providing <i>n</i>-3 polyunsaturated fatty acids in the human diet: A summary of the findings of a Biotechnology and Biological Sciences Research Council funded project. [PDF]

Nutr Bull, 2021
West AL, Miles EA, Lillycrop KA, Napier JA, Calder PC, Burdge GC.   +5 more
europepmc   +1 more source

Potential impact of genetically modified plants on biodiversity

, 2018
Currently, the introduction ofgenetically modified organisms (GMOs) has raised some concerns and the plantingareas of these organisms continue to expand every year. In recent years, it isforbidden to cultivate food and feeds produced with genetic engineeringtechnology in Turkey.
ARVAS, Yunus Emre, KAYA, Yılmaz
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source