Results 91 to 100 of about 55,739 (324)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Class III OFPs function in the ER signaling pathway to regulate plant growth and development in Arabidopsis

Journal of Plant Interactions, 2019
Both OFPs and ERECTA (ER) regulate plant response to environmental stresses as well as plant growth and development. Blunt-endeded siliques, the characterized phenotype of the er mutants, was observed in transgenic plants overexpressing Class III OFP ...
Xutong Wang, Wei Wang, Jie Wang, Na Zhang, Li Yang, Ling Cai, Saddam Hussain, Ying Chang, Shucai Wang   +8 more
doaj   +1 more source

Medical genetics and epigenetics of telomerase [PDF]

Journal of Cellular and Molecular Medicine, 2011
Telomerase is a specialized reverse transcriptase that extends and maintains the terminal ends of chromosomes, or telomeres. Since its discovery in 1985 by Nobel Laureates Elizabeth Blackburn and Carol Greider, thousands of articles have emerged detailing its significance in telomere function and cell survival. This review provides a current assessment
Koziel, Jillian E., Fox, Melanie J., Steding, Catherine E., Sprouse, Alyssa A., Herbert, Brittney-Shea   +4 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Genetics and Epigenetics in Adult Neurogenesis [PDF]

Cold Spring Harbor Perspectives in Biology, 2016
The cellular basis of adult neurogenesis is neural stem cells residing in restricted areas of the adult brain. These cells self-renew and are multipotent. The maintenance of "stemness" and commitment to differentiation are tightly controlled by intricate molecular networks.
Jenny, Hsieh, Xinyu, Zhao
openaire   +2 more sources

Genetics, Epigenetics, and Talent

, 2016
Looks at genes and their expression in athletic capability. There is no athletic gene; there is a general confluence of specific and general capabilities that converge on athletic expression.
Jay Schulkin
core   +1 more source

Epigenetics and epigenomics: implications for diabetes and obesity [PDF]

, 2018
The American Diabetes Association convened a research symposium, "Epigenetics and Epigenomics: Implications for Diabetes and Obesity" on 17-19 November 2017.
Natarajan, R., Sallari, R., Sander, M., Natarajan, Rama, Kaestner, K.H., Kaestner, Klaus H, Rosen, E.D., Susztak, Katalin, Patti, M.E., Rosen, Evan D, Sander, Maike, Susztak, K., Sallari, Richard, Patti, Mary-Elizabeth   +13 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The Genetics and Epigenetics of Sex Change in Fish.

Annual Review of Animal Biosciences, 2020
Fish show extraordinary sexual plasticity, changing sex naturally as part of their life cycle or reversing sex because of environmental stressors. This plasticity shows that sexual fate is not an irreversible process but the result of an ongoing tug-of ...
O. Ortega-Recalde, A. Goikoetxea, T. Hore, E. Todd, N. Gemmell   +4 more
semanticscholar   +1 more source

Epigenetics: More than Genetics [PDF]

Fly, 2008
n ...
SALA, Anna, CORONA, Davide
openaire   +3 more sources