Results 121 to 130 of about 55,739 (324)
Population epigenetics: Historical notes and applications in human health [PDF]
Genetics and Molecular BiologyA key factor contributing to the success of Darwin and Wallace’s theory of biological evolution by natural selection was its population-level perspective. This conceptual framework was not immediately adopted, largely due to the enduring intuitive appeal
Sergio Russo Matioli
doaj +2 more sources
, 2011 At the symposium, approaches to individualized cancer medicine were considered, from basic sciences (genetics, epigenetics, biological tumor signatures) to clinical investigations, including strategies about how best to undertake the clinical development
Liu, Edison +2 more
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Treatment personalization in gastrointestinal neuroendocrine tumors
, 2021 The clinical scenario of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) is continuously changing due to significant improvements in the definition of their molecular landscapes and the introduction of innovative therapeutic approaches.
Businello G. +8 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
A MeA Tac1 neural circuit mediates anxiety-like behaviors in mice
EMBO ReportsAnxiety is an emotion characterized by worried thoughts and feelings of unease, often accompanied by physical symptoms such as sweating and dizziness. Unlike other negative emotions, the neural circuits underlying anxiety are not well understood. Here we
Yao Wang +10 more
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, 2018 Supplemental material, 766097_supplementary_file_1 for Comprehensive Evaluation of Commercial Bisulfite-Based DNA Methylation Kits and Development of an Alternative Protocol With Improved Conversion Performance by Sascha Tierling, Beate Schmitt and Jörn ...
Sascha Tierling (265564) +2 more
core +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Entanglement of Genetics and Epigenetics in Parkinson’s Disease
Frontiers in Neuroscience, 2019 Parkinson disease (PD) is a common neurodegenerative disorder that progresses with age, with an increasing number of symptoms. Some of the efforts to understand PD progression have been focusing on the regulation of epigenetic mechanisms, that generally ...
H. J. van Heesbeen, Marten P. Smidt
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source